Chronic lymphocytic leukemia with 6q− shows distinct hematological features and intermediate prognosis

Cytogenetic and fluorescence in situ hybridization studies were successfully performed in 217 chronic lymphocytic leukemia (CLL). In all, 13 patients with 6q21 deletion were identified and characterized in comparison with 92 patients with ‘favourable’ karyotype (normal or 13q−), 69 cases with ‘inter...

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Veröffentlicht in:	Leukemia 2004-03, Vol.18 (3), p.476-483
Hauptverfasser:	Cuneo, A, Rigolin, G M, Bigoni, R, Angeli, C De, Veronese, A, Cavazzini, F, Bardi, A, Roberti, M G, Tammiso, E, Agostini, P, Ciccone, M, Porta, M Della, Tieghi, A, Cavazzini, L, Negrini, M, Castoldi, G
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase - genetics ADP-ribosyl Cyclase - metabolism ADP-ribosyl Cyclase 1 Adult Aged Aged, 80 and over Anomalies Antigens, CD - genetics Antigens, CD - metabolism Biological and medical sciences Blood Cancer Research CD38 antigen Chromosomes Chromosomes, Human, Pair 6 - genetics Chronic lymphocytic leukemia Critical Care Medicine Cytogenetics Cytology Female Fluorescence Fluorescence in situ hybridization Hematologic and hematopoietic diseases Hematology Homology Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin Heavy Chains - metabolism Immunoglobulin Variable Region - genetics Immunoglobulin Variable Region - metabolism In Situ Hybridization, Fluorescence Intensive Internal Medicine Interphase - genetics Karyotypes Karyotyping Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocytes Lymphatic leukemia Lymphocytes Male Medical prognosis Medical sciences Medicine Medicine & Public Health Membrane Glycoproteins Middle Aged Morphology Multivariate analysis Oncology original-manuscript Patients Prognosis Risk allocation Somatic hypermutation Splenomegaly Survival Survival Rate
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