HNF transfection with chondrosarcoma DNA results in the development of a sarcoma cell surface-associated epitope

High molecular weight DNA, which was isolated from a chondrosarcoma cell line, was transfected into human neonatal foreskin fibroblasts and NIH/3T3 cells. Both types of transfected cells expressed anchorage-independent growth in soft agar and produced tumors in nude mice. The tumors which developed...

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Veröffentlicht in:	Experimental and molecular pathology 1990-10, Vol.53 (2), p.167-179
Hauptverfasser:	Kumari, H.Lalitha, Shuler, Charles, Mannix, Daniel G., Milo, George E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Antigens, Neoplasm - genetics Antigens, Surface - immunology Biological and medical sciences Blotting, Southern Cell Adhesion - physiology Cell Line Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - immunology Cell Transformation, Neoplastic - pathology Chondrosarcoma - genetics Chondrosarcoma - immunology Chondrosarcoma - pathology DNA, Neoplasm - genetics Epitopes - genetics Epitopes - immunology Fibroblasts - cytology Fibroblasts - physiology Humans Male Medical sciences Mice Mice, Nude - genetics Transfection - genetics Transfection - physiology Tumors
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