Inhibition of myogenesis in transgenic mice expressing the human DMPK 3′-UTR

Myotonic dystrophy (DM1) is a multisystemic disorder caused by a CTG repeat expansion within the 3′-UTR of the DMPK gene. DM1 is characterized by delayed muscle development, muscle weakness and wasting, cardiac conduction abnormalities, cognitive defects and cataracts. Recent studies have demonstrat...

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Veröffentlicht in:	Human molecular genetics 2004-03, Vol.13 (6), p.589-600
Hauptverfasser:	Storbeck, Christopher J., Drmanic, Suzana, Daniel, Kate, Waring, James D., Jirik, Frank R., Parry, David J., Ahmed, Nazim, Sabourin, Luc A., Ikeda, Joh-E, Korneluk, Robert G.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Animals Biological and medical sciences Blotting, Northern Blotting, Western Classical genetics, quantitative genetics, hybrids Disease Models, Animal Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genetics of eukaryotes. Biological and molecular evolution Green Fluorescent Proteins Human Humans Immunohistochemistry In Situ Hybridization Luminescent Proteins Mice Mice, Transgenic Molecular and cellular biology Muscle Development - genetics Myoblasts - physiology Myogenin - genetics Myotonic Dystrophy - genetics Myotonin-Protein Kinase Protein-Serine-Threonine Kinases - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Transgenes - genetics Trinucleotide Repeat Expansion - genetics
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