Double leukemias simultaneously showing lymphoblastic leukemia of the bone marrow and monocytic leukemia of the central nervous system
A rare case of different leukemias simultaneously occurring in the bone marrow (BM) and the central nervous system (CNS) was encountered. A 4‐year‐old girl was diagnosed with acute lymphoblastic leukemia and achieved a complete remission with chemotherapy. Two years after diagnosis, she was found to...
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| Veröffentlicht in: | American journal of hematology 2004-03, Vol.75 (3), p.164-167 |
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| container_title | American journal of hematology |
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| creator | Ikarashi, Yukie Kakihara, Toshio Imai, Chihaya Tanaka, Atsushi Watanabe, Akihiro Uchiyama, Makoto |
| description | A rare case of different leukemias simultaneously occurring in the bone marrow (BM) and the central nervous system (CNS) was encountered. A 4‐year‐old girl was diagnosed with acute lymphoblastic leukemia and achieved a complete remission with chemotherapy. Two years after diagnosis, she was found to have acute monocytic leukemia at first relapse in the BM. One month after the second course of induction therapy, lymphoblastic leukemia in the BM and monocytic leukemia in the CNS were found simultaneously. Chromosomal analysis of leukemia cells in the BM and CNS showed distinct results. The mechanism of double leukemias occurring was obscure, although a lineage switch, therapy‐related, or de novo leukemia could be considered as possibilities. Double leukemias should be kept in mind when leukemias relapse in several sites. Am. J. Hematol. 75:164–167, 2004. © 2004 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajh.10478 |
| format | Article |
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A 4‐year‐old girl was diagnosed with acute lymphoblastic leukemia and achieved a complete remission with chemotherapy. Two years after diagnosis, she was found to have acute monocytic leukemia at first relapse in the BM. One month after the second course of induction therapy, lymphoblastic leukemia in the BM and monocytic leukemia in the CNS were found simultaneously. Chromosomal analysis of leukemia cells in the BM and CNS showed distinct results. The mechanism of double leukemias occurring was obscure, although a lineage switch, therapy‐related, or de novo leukemia could be considered as possibilities. Double leukemias should be kept in mind when leukemias relapse in several sites. Am. J. Hematol. 75:164–167, 2004. © 2004 Wiley‐Liss, Inc.</description><identifier>ISSN: 0361-8609</identifier><identifier>EISSN: 1096-8652</identifier><identifier>DOI: 10.1002/ajh.10478</identifier><identifier>PMID: 14978698</identifier><identifier>CODEN: AJHEDD</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biological and medical sciences ; Biomarkers, Tumor - analysis ; Bone Marrow Neoplasms - blood ; Bone Marrow Neoplasms - drug therapy ; Bone Marrow Neoplasms - genetics ; Bone Marrow Neoplasms - pathology ; central nervous system ; Central Nervous System Neoplasms - blood ; Central Nervous System Neoplasms - drug therapy ; Central Nervous System Neoplasms - genetics ; Central Nervous System Neoplasms - pathology ; Child, Preschool ; double leukemias ; Female ; Hematologic and hematopoietic diseases ; Histocytochemistry ; Humans ; Karyotyping ; Leukemia, Lymphoid - blood ; Leukemia, Lymphoid - drug therapy ; Leukemia, Lymphoid - genetics ; Leukemia, Lymphoid - pathology ; Leukemia, Monocytic, Acute - blood ; Leukemia, Monocytic, Acute - drug therapy ; Leukemia, Monocytic, Acute - genetics ; Leukemia, Monocytic, Acute - pathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. 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A 4‐year‐old girl was diagnosed with acute lymphoblastic leukemia and achieved a complete remission with chemotherapy. Two years after diagnosis, she was found to have acute monocytic leukemia at first relapse in the BM. One month after the second course of induction therapy, lymphoblastic leukemia in the BM and monocytic leukemia in the CNS were found simultaneously. Chromosomal analysis of leukemia cells in the BM and CNS showed distinct results. The mechanism of double leukemias occurring was obscure, although a lineage switch, therapy‐related, or de novo leukemia could be considered as possibilities. Double leukemias should be kept in mind when leukemias relapse in several sites. Am. J. Hematol. 75:164–167, 2004. © 2004 Wiley‐Liss, Inc.</description><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Bone Marrow Neoplasms - blood</subject><subject>Bone Marrow Neoplasms - drug therapy</subject><subject>Bone Marrow Neoplasms - genetics</subject><subject>Bone Marrow Neoplasms - pathology</subject><subject>central nervous system</subject><subject>Central Nervous System Neoplasms - blood</subject><subject>Central Nervous System Neoplasms - drug therapy</subject><subject>Central Nervous System Neoplasms - genetics</subject><subject>Central Nervous System Neoplasms - pathology</subject><subject>Child, Preschool</subject><subject>double leukemias</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Histocytochemistry</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Leukemia, Lymphoid - blood</subject><subject>Leukemia, Lymphoid - drug therapy</subject><subject>Leukemia, Lymphoid - genetics</subject><subject>Leukemia, Lymphoid - pathology</subject><subject>Leukemia, Monocytic, Acute - blood</subject><subject>Leukemia, Monocytic, Acute - drug therapy</subject><subject>Leukemia, Monocytic, Acute - genetics</subject><subject>Leukemia, Monocytic, Acute - pathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>lineage switch</subject><subject>Medical sciences</subject><subject>mixed leukemia</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Remission Induction</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1OxCAQB3BiNLp-HHwBw0UTD6vQAoWjWb9j4kXPDaVTt0rLCq2bvoDPLdqNXjSemMOPmcz8Edqn5IQSkpzq53ksWCbX0IQSJaZS8GQdTUgqaKyJ2kLbITwTQimTZBNtUaYyKZScoPdz1xcWsIX-BZpaBxzqpredbsH1wQ44zN2ybp-wHZrF3BVWh6423xy7CndzwIVrATfae7fEui1x41pnht-kgbbz2uIW_FucgMMQOmh20UalbYC91buDHi8vHmbX07v7q5vZ2d3UMJrJaZkaUqYJlVxDydO4TSpkVYBSptK0lLQoE6KShFdMxA9FJlPDmRIFNcDLKkt30NHYd-Hdaw-hy5s6GLB23DeXhEqilPgXJiRTTEgW4fEIjXcheKjyha_jJYackvwznTymk3-lE-3BqmlfNFD-yFUcERyugA5G28rr1tThx3GeEMl4dKejW9YWhr8n5me31-PoDz-SqQQ</recordid><startdate>200403</startdate><enddate>200403</enddate><creator>Ikarashi, Yukie</creator><creator>Kakihara, Toshio</creator><creator>Imai, Chihaya</creator><creator>Tanaka, Atsushi</creator><creator>Watanabe, Akihiro</creator><creator>Uchiyama, Makoto</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200403</creationdate><title>Double leukemias simultaneously showing lymphoblastic leukemia of the bone marrow and monocytic leukemia of the central nervous system</title><author>Ikarashi, Yukie ; Kakihara, Toshio ; Imai, Chihaya ; Tanaka, Atsushi ; Watanabe, Akihiro ; Uchiyama, Makoto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4178-d3c0d32185aed53148368fbe99cfa1d81bd209225f46417b783c5496b1ce5df73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Bone Marrow Neoplasms - blood</topic><topic>Bone Marrow Neoplasms - drug therapy</topic><topic>Bone Marrow Neoplasms - genetics</topic><topic>Bone Marrow Neoplasms - pathology</topic><topic>central nervous system</topic><topic>Central Nervous System Neoplasms - blood</topic><topic>Central Nervous System Neoplasms - drug therapy</topic><topic>Central Nervous System Neoplasms - genetics</topic><topic>Central Nervous System Neoplasms - pathology</topic><topic>Child, Preschool</topic><topic>double leukemias</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Histocytochemistry</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Leukemia, Lymphoid - blood</topic><topic>Leukemia, Lymphoid - drug therapy</topic><topic>Leukemia, Lymphoid - genetics</topic><topic>Leukemia, Lymphoid - pathology</topic><topic>Leukemia, Monocytic, Acute - blood</topic><topic>Leukemia, Monocytic, Acute - drug therapy</topic><topic>Leukemia, Monocytic, Acute - genetics</topic><topic>Leukemia, Monocytic, Acute - pathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>lineage switch</topic><topic>Medical sciences</topic><topic>mixed leukemia</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Remission Induction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ikarashi, Yukie</creatorcontrib><creatorcontrib>Kakihara, Toshio</creatorcontrib><creatorcontrib>Imai, Chihaya</creatorcontrib><creatorcontrib>Tanaka, Atsushi</creatorcontrib><creatorcontrib>Watanabe, Akihiro</creatorcontrib><creatorcontrib>Uchiyama, Makoto</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ikarashi, Yukie</au><au>Kakihara, Toshio</au><au>Imai, Chihaya</au><au>Tanaka, Atsushi</au><au>Watanabe, Akihiro</au><au>Uchiyama, Makoto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Double leukemias simultaneously showing lymphoblastic leukemia of the bone marrow and monocytic leukemia of the central nervous system</atitle><jtitle>American journal of hematology</jtitle><addtitle>Am J Hematol</addtitle><date>2004-03</date><risdate>2004</risdate><volume>75</volume><issue>3</issue><spage>164</spage><epage>167</epage><pages>164-167</pages><issn>0361-8609</issn><eissn>1096-8652</eissn><coden>AJHEDD</coden><abstract>A rare case of different leukemias simultaneously occurring in the bone marrow (BM) and the central nervous system (CNS) was encountered. 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| ispartof | American journal of hematology, 2004-03, Vol.75 (3), p.164-167 |
| issn | 0361-8609 1096-8652 |
| language | eng |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biological and medical sciences Biomarkers, Tumor - analysis Bone Marrow Neoplasms - blood Bone Marrow Neoplasms - drug therapy Bone Marrow Neoplasms - genetics Bone Marrow Neoplasms - pathology central nervous system Central Nervous System Neoplasms - blood Central Nervous System Neoplasms - drug therapy Central Nervous System Neoplasms - genetics Central Nervous System Neoplasms - pathology Child, Preschool double leukemias Female Hematologic and hematopoietic diseases Histocytochemistry Humans Karyotyping Leukemia, Lymphoid - blood Leukemia, Lymphoid - drug therapy Leukemia, Lymphoid - genetics Leukemia, Lymphoid - pathology Leukemia, Monocytic, Acute - blood Leukemia, Monocytic, Acute - drug therapy Leukemia, Monocytic, Acute - genetics Leukemia, Monocytic, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis lineage switch Medical sciences mixed leukemia Neoplasm Recurrence, Local - pathology Remission Induction |
| title | Double leukemias simultaneously showing lymphoblastic leukemia of the bone marrow and monocytic leukemia of the central nervous system |
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