Reduction of β-Endorphin-Containing Immune Cells in Inflamed Paw Tissue Corresponds with a Reduction in Immune-Derived Antinociception: Reversible by Donor Activated Lymphocytes

The functional integrity of the immune system is essential for peripheral antinociception. Previous studies have demonstrated that immune cells elicit potent antinociception in inflamed tissues and that corticotropin-releasing factor-induced antinociception is significantly inhibited in animals that...

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Veröffentlicht in:	Anesthesia and analgesia 2004-03, Vol.98 (3), p.723-729
Hauptverfasser:	Hermanussen, Siobhan, Do, MyHong, Cabot, Peter John
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals beta-Endorphin - metabolism Biological and medical sciences CD4 Lymphocyte Count Concanavalin A Cyclosporine - pharmacology Dose-Response Relationship, Drug Fluorescent Antibody Technique Foot - pathology Freund's Adjuvant Immunosuppressive Agents - pharmacology Inflammation - chemically induced Inflammation - immunology Inflammation - metabolism Lymphocyte Activation - physiology Lymphocytes - immunology Lymphocytes - physiology Male Medical sciences Pain Threshold - drug effects Pain Threshold - physiology Radioimmunoassay Rats Rats, Wistar
Online-Zugang:	Volltext
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