Structure-activity studies on the C-terminal amide of substance P

Twelve C-terminal heptapeptide analogues of substance P have been synthesized by solid phase and by the classical solution method. The modifications concerned all the C-terminal primary amide of SP and should therefore help to understand the biological significance of this carboxamide, as evaluated...

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Veröffentlicht in:	Journal of medicinal chemistry 1982-11, Vol.25 (11), p.1317-1321
Hauptverfasser:	Escher, Emanuel, Couture, Rejean, Poulos, Constantinos, Pinas, Nikos, Mizrahi, Jacques, Theodoropoulos, Dimitrios, Regoli, Domenico
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - drug effects Guinea Pigs In Vitro Techniques Muscle Contraction - drug effects Muscle, Smooth - drug effects Peptide Fragments - pharmacology Rats Structure-Activity Relationship Substance P - pharmacology
Online-Zugang:	Volltext
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