Ischemic and viable myocardium in patients with non-Q-wave or Q-wave myocardial infarction and left ventricular dysfunction: a clinical study using positron emission tomography, echocardiography, and electrocardiography
We investigated whether patients with non-Q-wave myocardial infarction (NQMI) have more ischemic viable myocardium (IVM) than patients with Q-wave myocardial infarction (QMI). Non-Q-wave myocardial infarction is associated with higher incidences of cardiac events than QMI, suggesting more myocardium...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2004-02, Vol.43 (4), p.592-598 |
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| creator | Yang, Hua Pu, Min Rodriguez, David Underwood, Donald Griffin, Brian P Kalahasti, Vidyasagar Thomas, James D Brunken, Richard C |
| description | We investigated whether patients with non-Q-wave myocardial infarction (NQMI) have more ischemic viable myocardium (IVM) than patients with Q-wave myocardial infarction (QMI).
Non-Q-wave myocardial infarction is associated with higher incidences of cardiac events than QMI, suggesting more myocardium at risk in NQMI.
To identify myocardial ischemia, hibernation, and scar, the resting and stress (82)rubidium perfusion and F-18 fluorodeoxyglucose metabolic positron emission tomographic imaging (PET) was performed in 64 consecutive patients with NQMI (n = 21) or QMI (n = 43). Echocardiography was performed for assessment of left ventricular function and wall motion index (WMI). The relationships between PET, echocardiographic, and electrocardiographic findings were analyzed.
There were no significant differences in left ventricular ejection fraction (LVEF) between NQMI and QMI groups (28 +/- 10% vs. 25 +/- 11%, p > 0.05). Ischemic and viable myocardium was more common in NQMI than in QMI (91% vs. 61%, p < 0.05). The total amount of IVM was significantly higher in NQMI than in QMI (6.5 +/- 5.2 vs. 2.9 +/- 2.8 segments, p < 0.001). Neither the number of Q waves, residual ST-segment depression of >or=0.5 mm or elevation of >or=1 mm, nor LVEF and WMI were significant predictors for IVM. Wall motion index correlated with scar segments (r = 0.54, p < 0.001) and LVEF (r = -0.67, p < 0.001).
Ischemic and viable myocardium is common in patients with NQMI and left ventricular dysfunction, suggesting that aggressive approaches should be taken to salvage the myocardium at risk in such patients. |
| doi_str_mv | 10.1016/j.jacc.2003.07.052 |
| format | Article |
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Non-Q-wave myocardial infarction is associated with higher incidences of cardiac events than QMI, suggesting more myocardium at risk in NQMI.
To identify myocardial ischemia, hibernation, and scar, the resting and stress (82)rubidium perfusion and F-18 fluorodeoxyglucose metabolic positron emission tomographic imaging (PET) was performed in 64 consecutive patients with NQMI (n = 21) or QMI (n = 43). Echocardiography was performed for assessment of left ventricular function and wall motion index (WMI). The relationships between PET, echocardiographic, and electrocardiographic findings were analyzed.
There were no significant differences in left ventricular ejection fraction (LVEF) between NQMI and QMI groups (28 +/- 10% vs. 25 +/- 11%, p > 0.05). Ischemic and viable myocardium was more common in NQMI than in QMI (91% vs. 61%, p < 0.05). The total amount of IVM was significantly higher in NQMI than in QMI (6.5 +/- 5.2 vs. 2.9 +/- 2.8 segments, p < 0.001). Neither the number of Q waves, residual ST-segment depression of >or=0.5 mm or elevation of >or=1 mm, nor LVEF and WMI were significant predictors for IVM. Wall motion index correlated with scar segments (r = 0.54, p < 0.001) and LVEF (r = -0.67, p < 0.001).
Ischemic and viable myocardium is common in patients with NQMI and left ventricular dysfunction, suggesting that aggressive approaches should be taken to salvage the myocardium at risk in such patients.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2003.07.052</identifier><identifier>PMID: 14975469</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Cardiology ; Case-Control Studies ; Defects ; Echocardiography ; Electrocardiography ; Enzymes ; Female ; Fluorodeoxyglucose F18 ; Heart - diagnostic imaging ; Heart attacks ; Humans ; Ischemia ; Kinases ; Male ; Medical prognosis ; Middle Aged ; Mortality ; Myocardial Infarction - diagnosis ; Myocardial Infarction - physiopathology ; Myocardial Ischemia - diagnosis ; Myocardial Ischemia - physiopathology ; Prognosis ; Radiopharmaceuticals ; Rubidium Radioisotopes ; Stroke Volume - physiology ; Studies ; Tomography, Emission-Computed ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>Journal of the American College of Cardiology, 2004-02, Vol.43 (4), p.592-598</ispartof><rights>Copyright Elsevier Limited Feb 18, 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14975469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Hua</creatorcontrib><creatorcontrib>Pu, Min</creatorcontrib><creatorcontrib>Rodriguez, David</creatorcontrib><creatorcontrib>Underwood, Donald</creatorcontrib><creatorcontrib>Griffin, Brian P</creatorcontrib><creatorcontrib>Kalahasti, Vidyasagar</creatorcontrib><creatorcontrib>Thomas, James D</creatorcontrib><creatorcontrib>Brunken, Richard C</creatorcontrib><title>Ischemic and viable myocardium in patients with non-Q-wave or Q-wave myocardial infarction and left ventricular dysfunction: a clinical study using positron emission tomography, echocardiography, and electrocardiography</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>We investigated whether patients with non-Q-wave myocardial infarction (NQMI) have more ischemic viable myocardium (IVM) than patients with Q-wave myocardial infarction (QMI).
Non-Q-wave myocardial infarction is associated with higher incidences of cardiac events than QMI, suggesting more myocardium at risk in NQMI.
To identify myocardial ischemia, hibernation, and scar, the resting and stress (82)rubidium perfusion and F-18 fluorodeoxyglucose metabolic positron emission tomographic imaging (PET) was performed in 64 consecutive patients with NQMI (n = 21) or QMI (n = 43). Echocardiography was performed for assessment of left ventricular function and wall motion index (WMI). The relationships between PET, echocardiographic, and electrocardiographic findings were analyzed.
There were no significant differences in left ventricular ejection fraction (LVEF) between NQMI and QMI groups (28 +/- 10% vs. 25 +/- 11%, p > 0.05). Ischemic and viable myocardium was more common in NQMI than in QMI (91% vs. 61%, p < 0.05). The total amount of IVM was significantly higher in NQMI than in QMI (6.5 +/- 5.2 vs. 2.9 +/- 2.8 segments, p < 0.001). Neither the number of Q waves, residual ST-segment depression of >or=0.5 mm or elevation of >or=1 mm, nor LVEF and WMI were significant predictors for IVM. Wall motion index correlated with scar segments (r = 0.54, p < 0.001) and LVEF (r = -0.67, p < 0.001).
Ischemic and viable myocardium is common in patients with NQMI and left ventricular dysfunction, suggesting that aggressive approaches should be taken to salvage the myocardium at risk in such patients.</description><subject>Cardiology</subject><subject>Case-Control Studies</subject><subject>Defects</subject><subject>Echocardiography</subject><subject>Electrocardiography</subject><subject>Enzymes</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Heart - diagnostic imaging</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Kinases</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Ischemia - diagnosis</subject><subject>Myocardial Ischemia - physiopathology</subject><subject>Prognosis</subject><subject>Radiopharmaceuticals</subject><subject>Rubidium Radioisotopes</subject><subject>Stroke Volume - physiology</subject><subject>Studies</subject><subject>Tomography, Emission-Computed</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc2K1TAYhoMoznH0BlxIQHBla9I0TeNuGPwZGBBB1yXnazrNIU1qfs7Qa_VmzMycEXGVkDzP-70kCL2mpKaEdh8O9UEB1A0hrCaiJrx5gnaU875iXIqnaEcE4xUlUpyhFzEeCCFdT-VzdEZbKXjbyR36fRVh1osBrNyIj0btrcbL5kGF0eQFG4dXlYx2KeJbk2bsvKu-V7fqqLEP-LR7FJQtwqQCJOPdfaLVU8LHogcD2aqAxy1O2d0DH7HCYI0zULyY8rjhHI27wauPJoWSUIrFeBeV_OJvglrn7T3WMD9M-3tyN0hbDcX59-IlejYpG_Wr03qOfn7-9OPya3X97cvV5cV1NTedTJUAJqlUYgSuhdICJkpFqzpW3gj2suEtl7ybRiImYLRXTbuXgoxSNhIosJado3cPuWvwv7KOaSi1QVurnPY5Dj2hoie9LODb_8CDz8GVbgPlpKNt1xNeqDcnKu8XPQ5rMIsK2_D4aewPw_mgUg</recordid><startdate>20040218</startdate><enddate>20040218</enddate><creator>Yang, Hua</creator><creator>Pu, Min</creator><creator>Rodriguez, David</creator><creator>Underwood, Donald</creator><creator>Griffin, Brian P</creator><creator>Kalahasti, Vidyasagar</creator><creator>Thomas, James D</creator><creator>Brunken, Richard C</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20040218</creationdate><title>Ischemic and viable myocardium in patients with non-Q-wave or Q-wave myocardial infarction and left ventricular dysfunction: a clinical study using positron emission tomography, echocardiography, and electrocardiography</title><author>Yang, Hua ; Pu, Min ; Rodriguez, David ; Underwood, Donald ; Griffin, Brian P ; Kalahasti, Vidyasagar ; Thomas, James D ; Brunken, Richard C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h269t-7c3919a7dc5e7ae7cf1174a63975cb92545956fd07fc318a24b970d9929c1c343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Cardiology</topic><topic>Case-Control Studies</topic><topic>Defects</topic><topic>Echocardiography</topic><topic>Electrocardiography</topic><topic>Enzymes</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Heart - diagnostic imaging</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Kinases</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardial Ischemia - diagnosis</topic><topic>Myocardial Ischemia - physiopathology</topic><topic>Prognosis</topic><topic>Radiopharmaceuticals</topic><topic>Rubidium Radioisotopes</topic><topic>Stroke Volume - physiology</topic><topic>Studies</topic><topic>Tomography, Emission-Computed</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Hua</creatorcontrib><creatorcontrib>Pu, Min</creatorcontrib><creatorcontrib>Rodriguez, David</creatorcontrib><creatorcontrib>Underwood, Donald</creatorcontrib><creatorcontrib>Griffin, Brian P</creatorcontrib><creatorcontrib>Kalahasti, Vidyasagar</creatorcontrib><creatorcontrib>Thomas, James D</creatorcontrib><creatorcontrib>Brunken, Richard C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Hua</au><au>Pu, Min</au><au>Rodriguez, David</au><au>Underwood, Donald</au><au>Griffin, Brian P</au><au>Kalahasti, Vidyasagar</au><au>Thomas, James D</au><au>Brunken, Richard C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ischemic and viable myocardium in patients with non-Q-wave or Q-wave myocardial infarction and left ventricular dysfunction: a clinical study using positron emission tomography, echocardiography, and electrocardiography</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2004-02-18</date><risdate>2004</risdate><volume>43</volume><issue>4</issue><spage>592</spage><epage>598</epage><pages>592-598</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><abstract>We investigated whether patients with non-Q-wave myocardial infarction (NQMI) have more ischemic viable myocardium (IVM) than patients with Q-wave myocardial infarction (QMI).
Non-Q-wave myocardial infarction is associated with higher incidences of cardiac events than QMI, suggesting more myocardium at risk in NQMI.
To identify myocardial ischemia, hibernation, and scar, the resting and stress (82)rubidium perfusion and F-18 fluorodeoxyglucose metabolic positron emission tomographic imaging (PET) was performed in 64 consecutive patients with NQMI (n = 21) or QMI (n = 43). Echocardiography was performed for assessment of left ventricular function and wall motion index (WMI). The relationships between PET, echocardiographic, and electrocardiographic findings were analyzed.
There were no significant differences in left ventricular ejection fraction (LVEF) between NQMI and QMI groups (28 +/- 10% vs. 25 +/- 11%, p > 0.05). Ischemic and viable myocardium was more common in NQMI than in QMI (91% vs. 61%, p < 0.05). The total amount of IVM was significantly higher in NQMI than in QMI (6.5 +/- 5.2 vs. 2.9 +/- 2.8 segments, p < 0.001). Neither the number of Q waves, residual ST-segment depression of >or=0.5 mm or elevation of >or=1 mm, nor LVEF and WMI were significant predictors for IVM. Wall motion index correlated with scar segments (r = 0.54, p < 0.001) and LVEF (r = -0.67, p < 0.001).
Ischemic and viable myocardium is common in patients with NQMI and left ventricular dysfunction, suggesting that aggressive approaches should be taken to salvage the myocardium at risk in such patients.</abstract><cop>United States</cop><pub>Elsevier Limited</pub><pmid>14975469</pmid><doi>10.1016/j.jacc.2003.07.052</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present); Alma/SFX Local Collection |
| subjects | Cardiology Case-Control Studies Defects Echocardiography Electrocardiography Enzymes Female Fluorodeoxyglucose F18 Heart - diagnostic imaging Heart attacks Humans Ischemia Kinases Male Medical prognosis Middle Aged Mortality Myocardial Infarction - diagnosis Myocardial Infarction - physiopathology Myocardial Ischemia - diagnosis Myocardial Ischemia - physiopathology Prognosis Radiopharmaceuticals Rubidium Radioisotopes Stroke Volume - physiology Studies Tomography, Emission-Computed Ventricular Dysfunction, Left - physiopathology |
| title | Ischemic and viable myocardium in patients with non-Q-wave or Q-wave myocardial infarction and left ventricular dysfunction: a clinical study using positron emission tomography, echocardiography, and electrocardiography |
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