Phospho-Serine-118 Estrogen Receptor-α Detection in Human Breast Tumors in Vivo

Purpose: To determine whether estrogen receptor (ER)-α specifically phosphorylated at Ser 118 is detectable in multiple human breast cancer biopsy samples. To gain insight into possible roles for P-Ser 118 -ERα in human breast cancer in vivo . Experimental Design: A specific antibody for P-Ser 118 -...

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Veröffentlicht in:	Clinical cancer research 2004-02, Vol.10 (4), p.1354-1359
Hauptverfasser:	MURPHY, Leigh, CHERLET, Tracy, ADEYINKA, Adewale, YULIAN NIU, SNELL, Linda, WATSON, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Biomarkers, Tumor Biopsy Blotting, Western Breast Neoplasms - metabolism Cell Differentiation Cell Line, Tumor Enzyme Inhibitors - pharmacology Estrogen Receptor alpha Flavonoids - pharmacology Humans Immunohistochemistry Ligands Lymphatic Metastasis MAP Kinase Signaling System Medical sciences Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Pharmacology. Drug treatments Phenotype Phosphorylation Phosphoserine - chemistry Prognosis Receptors, Estrogen - biosynthesis Serine - chemistry Tumors
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