Perturbation of the NH2 pKa Value of Adenine in Platinum(II) Complexes: Distinct Stereochemical Internucleobase Effects

The degree of acidification of the exocyclic N6 amino group of the model nucleobase 9‐methyladenine (9MeA) in relation to the number and site(s) of PtII binding has been studied in detail. It is found that twofold PtII binding to N1 and N7 lowers the pKa value from 16.7 in the free base to 12–8. The...

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Veröffentlicht in:	Chemistry : a European journal 2004-02, Vol.10 (4), p.1046-1057
Hauptverfasser:	Garijo Añorbe, Marta, Lüth, Marc Sven, Roitzsch, Michael, Morell Cerdà, Marta, Lax, Patrick, Kampf, Gunnar, Sigel, Helmut, Lippert, Bernhard
Format:	Artikel
Sprache:	eng
Schlagworte:	acidity hydrogen bonds nucleobases platinum
Online-Zugang:	Volltext
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