Laboratory Diagnosis of Canine GM2-Gangliosidosis using Blood and Cerebrospinal Fluid

In the present study, laboratory techniques were used to diagnose canine GM2-gangliosidosis using blood and cerebrospinal fluid (CSF) that can be collected noninvasively from living individuals. Lysosomal acid β-hexosaminidase (Hex) was measured spectrofluorometrically using 4-methylumbelliferyl N-a...

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Veröffentlicht in:	Journal of veterinary diagnostic investigation 2004, Vol.16 (1), p.39-44
Hauptverfasser:	Yamato, Osamu, Satoh, Hiroyuki, Matsuki, Naoaki, Ono, Kenichiro, Yamasaki, Masahiro, Maede, Yoshimitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-N-Acetylhexosaminidases - blood beta-N-Acetylhexosaminidases - cerebrospinal fluid cellulose acetate cerebrospinal fluid Chromatography, Thin Layer - veterinary Dog Diseases - blood Dog Diseases - cerebrospinal fluid Dog Diseases - enzymology Dogs early diagnosis electrophoresis Electrophoresis, Cellulose Acetate - veterinary enzyme activity G(M2) Ganglioside - cerebrospinal fluid Gangliosidoses, GM2 - blood Gangliosidoses, GM2 - cerebrospinal fluid Gangliosidoses, GM2 - enzymology Gangliosidoses, GM2 - veterinary Hexosaminidase A Hexosaminidase B Isoenzymes - blood laboratory techniques leukocytes Leukocytes - enzymology Male Sandhoff Disease - diagnosis Sandhoff Disease - enzymology Sandhoff Disease - veterinary
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