Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase1 expression and enzyme activity
The trans-10, cis-12 isomer of conjugated linoleic acid (CLA) reduces body fat gain in animals and inhibits stearoyl-CoA desaturase (SCD) activity in 3T3-L1 adipocytes. To test whether CLA’s body fat reduction is mediated by SCD1, wild-type and SCD1-null mice were fed diet supplemented with 0.2% tra...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2004-03, Vol.315 (3), p.532-537 |
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| creator | Kang, Kihwa Miyazaki, Makoto Ntambi, James M Pariza, Michael W |
| description | The
trans-10,
cis-12 isomer of conjugated linoleic acid (CLA) reduces body fat gain in animals and inhibits stearoyl-CoA desaturase (SCD) activity in 3T3-L1 adipocytes. To test whether CLA’s body fat reduction is mediated by SCD1, wild-type and SCD1-null mice were fed diet supplemented with 0.2%
trans-10,
cis-12 (t10c12) CLA for 4 weeks. The t10c12 CLA-supplemented diet significantly reduced body fat mass in both wild type and SCD1-null mice. Similarly, t10c12 CLA diet decreased blood triglyceride and free fatty acid levels regardless of SCD1 genotypes. Mice fed t10c12 CLA exhibited increased mRNA expression of fatty acid synthase and uncoupling protein 2 in both genotypes. Taken together, the effects of t10c12 CLA on reduction of body fat gain, blood parameters, and mRNA expression in both SCD1-null mice and wild-type mice were similar, indicating that the anti-obesity effect of t10c12 CLA may be independent of the effects of this CLA isomer on SCD1 gene expression and enzyme activity. |
| doi_str_mv | 10.1016/j.bbrc.2004.01.087 |
| format | Article |
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trans-10,
cis-12 isomer of conjugated linoleic acid (CLA) reduces body fat gain in animals and inhibits stearoyl-CoA desaturase (SCD) activity in 3T3-L1 adipocytes. To test whether CLA’s body fat reduction is mediated by SCD1, wild-type and SCD1-null mice were fed diet supplemented with 0.2%
trans-10,
cis-12 (t10c12) CLA for 4 weeks. The t10c12 CLA-supplemented diet significantly reduced body fat mass in both wild type and SCD1-null mice. Similarly, t10c12 CLA diet decreased blood triglyceride and free fatty acid levels regardless of SCD1 genotypes. Mice fed t10c12 CLA exhibited increased mRNA expression of fatty acid synthase and uncoupling protein 2 in both genotypes. Taken together, the effects of t10c12 CLA on reduction of body fat gain, blood parameters, and mRNA expression in both SCD1-null mice and wild-type mice were similar, indicating that the anti-obesity effect of t10c12 CLA may be independent of the effects of this CLA isomer on SCD1 gene expression and enzyme activity.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2004.01.087</identifier><identifier>PMID: 14975733</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>3-Hydroxybutyric Acid - blood ; Adipose tissue ; Adipose Tissue - chemistry ; Adipose Tissue - metabolism ; Animal Feed ; Animals ; Anti-Obesity Agents - chemistry ; Anti-Obesity Agents - pharmacology ; Blood Glucose - analysis ; Body Weight - drug effects ; Cholesterol - blood ; Conjugated linoleic acid ; Fats - analysis ; Fatty Acids - analysis ; Fatty Acids - chemistry ; Gene Expression ; Linoleic Acid - chemistry ; Linoleic Acid - pharmacology ; Liver - chemistry ; Male ; Mice ; Mice, Knockout ; Muscles - chemistry ; RNA, Messenger - biosynthesis ; Stearoyl-CoA desaturase ; Stearoyl-CoA Desaturase - deficiency ; Stearoyl-CoA Desaturase - genetics ; Stearoyl-CoA Desaturase - metabolism ; Trans-10, cis-12 CLA ; Triglycerides - blood</subject><ispartof>Biochemical and biophysical research communications, 2004-03, Vol.315 (3), p.532-537</ispartof><rights>2004 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c298t-91e7967afb421d3c88e918632efe0f6b53e4a0745aaccbcba0ca0f6427e07dde3</citedby><cites>FETCH-LOGICAL-c298t-91e7967afb421d3c88e918632efe0f6b53e4a0745aaccbcba0ca0f6427e07dde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X0400141X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14975733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Kihwa</creatorcontrib><creatorcontrib>Miyazaki, Makoto</creatorcontrib><creatorcontrib>Ntambi, James M</creatorcontrib><creatorcontrib>Pariza, Michael W</creatorcontrib><title>Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase1 expression and enzyme activity</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The
trans-10,
cis-12 isomer of conjugated linoleic acid (CLA) reduces body fat gain in animals and inhibits stearoyl-CoA desaturase (SCD) activity in 3T3-L1 adipocytes. To test whether CLA’s body fat reduction is mediated by SCD1, wild-type and SCD1-null mice were fed diet supplemented with 0.2%
trans-10,
cis-12 (t10c12) CLA for 4 weeks. The t10c12 CLA-supplemented diet significantly reduced body fat mass in both wild type and SCD1-null mice. Similarly, t10c12 CLA diet decreased blood triglyceride and free fatty acid levels regardless of SCD1 genotypes. Mice fed t10c12 CLA exhibited increased mRNA expression of fatty acid synthase and uncoupling protein 2 in both genotypes. Taken together, the effects of t10c12 CLA on reduction of body fat gain, blood parameters, and mRNA expression in both SCD1-null mice and wild-type mice were similar, indicating that the anti-obesity effect of t10c12 CLA may be independent of the effects of this CLA isomer on SCD1 gene expression and enzyme activity.</description><subject>3-Hydroxybutyric Acid - blood</subject><subject>Adipose tissue</subject><subject>Adipose Tissue - chemistry</subject><subject>Adipose Tissue - metabolism</subject><subject>Animal Feed</subject><subject>Animals</subject><subject>Anti-Obesity Agents - chemistry</subject><subject>Anti-Obesity Agents - pharmacology</subject><subject>Blood Glucose - analysis</subject><subject>Body Weight - drug effects</subject><subject>Cholesterol - blood</subject><subject>Conjugated linoleic acid</subject><subject>Fats - analysis</subject><subject>Fatty Acids - analysis</subject><subject>Fatty Acids - chemistry</subject><subject>Gene Expression</subject><subject>Linoleic Acid - chemistry</subject><subject>Linoleic Acid - pharmacology</subject><subject>Liver - chemistry</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Muscles - chemistry</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Stearoyl-CoA desaturase</subject><subject>Stearoyl-CoA Desaturase - deficiency</subject><subject>Stearoyl-CoA Desaturase - genetics</subject><subject>Stearoyl-CoA Desaturase - metabolism</subject><subject>Trans-10, cis-12 CLA</subject><subject>Triglycerides - blood</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGKFDEQhoMo7uzqC3iQnLx1W5Xu6XSDl2VYXWHBi4K3kE6qNUNPMibpYccH8XnNOAPe9FKB8P1VRX2MvUKoEbB7u63HMZpaALQ1YA29fMJWCANUAqF9ylYA0FViwK9X7DqlLQBi2w3P2RW2g1zLplmxX3cHZ8kb4vm7zqUQ1z67KoyUXD5ymiYymYeJm-C3yzedyfLZ-TCTM1wbZ7lL3HlLeyrF_0HPocSD5ymTjuE4V5twyy0lnZeoEyGnx32klFxhtLec_M_jrsw22R3K3Bfs2aTnRC8v7w378v7u8-a-evj04ePm9qEyYuhzNSDJoZN6GluBtjF9TwP2XSNoIpi6cd1Qq0G2a62NGc2owejy3wpJIK2l5oa9Offdx_BjoZTVziVD86w9hSWpHlCu-779L4hlDwEdFFCcQRNDSpEmtY9up-NRIaiTNrVVJ23qpE0BqqKthF5fui_jjuzfyMVTAd6dASrHODiKKhl30mZdLKdWNrh_9f8NZhaszg</recordid><startdate>20040312</startdate><enddate>20040312</enddate><creator>Kang, Kihwa</creator><creator>Miyazaki, Makoto</creator><creator>Ntambi, James M</creator><creator>Pariza, Michael W</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040312</creationdate><title>Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase1 expression and enzyme activity</title><author>Kang, Kihwa ; Miyazaki, Makoto ; Ntambi, James M ; Pariza, Michael W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-91e7967afb421d3c88e918632efe0f6b53e4a0745aaccbcba0ca0f6427e07dde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>3-Hydroxybutyric Acid - blood</topic><topic>Adipose tissue</topic><topic>Adipose Tissue - chemistry</topic><topic>Adipose Tissue - metabolism</topic><topic>Animal Feed</topic><topic>Animals</topic><topic>Anti-Obesity Agents - chemistry</topic><topic>Anti-Obesity Agents - pharmacology</topic><topic>Blood Glucose - analysis</topic><topic>Body Weight - drug effects</topic><topic>Cholesterol - blood</topic><topic>Conjugated linoleic acid</topic><topic>Fats - analysis</topic><topic>Fatty Acids - analysis</topic><topic>Fatty Acids - chemistry</topic><topic>Gene Expression</topic><topic>Linoleic Acid - chemistry</topic><topic>Linoleic Acid - pharmacology</topic><topic>Liver - chemistry</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Muscles - chemistry</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Stearoyl-CoA desaturase</topic><topic>Stearoyl-CoA Desaturase - deficiency</topic><topic>Stearoyl-CoA Desaturase - genetics</topic><topic>Stearoyl-CoA Desaturase - metabolism</topic><topic>Trans-10, cis-12 CLA</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Kihwa</creatorcontrib><creatorcontrib>Miyazaki, Makoto</creatorcontrib><creatorcontrib>Ntambi, James M</creatorcontrib><creatorcontrib>Pariza, Michael W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Kihwa</au><au>Miyazaki, Makoto</au><au>Ntambi, James M</au><au>Pariza, Michael W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase1 expression and enzyme activity</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2004-03-12</date><risdate>2004</risdate><volume>315</volume><issue>3</issue><spage>532</spage><epage>537</epage><pages>532-537</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>The
trans-10,
cis-12 isomer of conjugated linoleic acid (CLA) reduces body fat gain in animals and inhibits stearoyl-CoA desaturase (SCD) activity in 3T3-L1 adipocytes. To test whether CLA’s body fat reduction is mediated by SCD1, wild-type and SCD1-null mice were fed diet supplemented with 0.2%
trans-10,
cis-12 (t10c12) CLA for 4 weeks. The t10c12 CLA-supplemented diet significantly reduced body fat mass in both wild type and SCD1-null mice. Similarly, t10c12 CLA diet decreased blood triglyceride and free fatty acid levels regardless of SCD1 genotypes. Mice fed t10c12 CLA exhibited increased mRNA expression of fatty acid synthase and uncoupling protein 2 in both genotypes. Taken together, the effects of t10c12 CLA on reduction of body fat gain, blood parameters, and mRNA expression in both SCD1-null mice and wild-type mice were similar, indicating that the anti-obesity effect of t10c12 CLA may be independent of the effects of this CLA isomer on SCD1 gene expression and enzyme activity.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>14975733</pmid><doi>10.1016/j.bbrc.2004.01.087</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 3-Hydroxybutyric Acid - blood Adipose tissue Adipose Tissue - chemistry Adipose Tissue - metabolism Animal Feed Animals Anti-Obesity Agents - chemistry Anti-Obesity Agents - pharmacology Blood Glucose - analysis Body Weight - drug effects Cholesterol - blood Conjugated linoleic acid Fats - analysis Fatty Acids - analysis Fatty Acids - chemistry Gene Expression Linoleic Acid - chemistry Linoleic Acid - pharmacology Liver - chemistry Male Mice Mice, Knockout Muscles - chemistry RNA, Messenger - biosynthesis Stearoyl-CoA desaturase Stearoyl-CoA Desaturase - deficiency Stearoyl-CoA Desaturase - genetics Stearoyl-CoA Desaturase - metabolism Trans-10, cis-12 CLA Triglycerides - blood |
| title | Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase1 expression and enzyme activity |
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