A new proposal for the mechanism of glycine hydroxylation as catalyzed by peptidylglycine α-hydroxylating monooxygenase (PHM)

The title enzyme, peptidylglycine α-hydroxylating monooxygenase (PHM), is essential to the in vivo generation of a wide variety of physiologically significant α-amidated peptide hormones from the corresponding C-terminal glycine-extended prohormones. Over a 20-year period of time a massive amount of...

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Veröffentlicht in:	Medical hypotheses 2004-01, Vol.62 (3), p.392-400
Hauptverfasser:	Owen, Terence C, Merkler, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbon Monoxide - metabolism Catalytic Domain Copper - metabolism Crystallography, X-Ray Glycine - metabolism Humans Mixed Function Oxygenases - chemistry Mixed Function Oxygenases - metabolism Multienzyme Complexes - chemistry Multienzyme Complexes - metabolism
Online-Zugang:	Volltext
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