Molecular Characterization of Postnatal Development of Testicular Steroidogenesis in Luteinizing Hormone Receptor Knockout Mice

We recently demonstrated that the sexual development of LH receptor (LHR) knockout mice is normal until birth, but is totally arrested thereafter. To study further the functional defects of LHR knockout mice, the expression of selected Leydig cell-specific genes was studied in (−/−) and control (+/+...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2004-03, Vol.145 (3), p.1453-1463
Hauptverfasser:	Zhang, Fu-ping, Pakarainen, Tomi, Zhu, Fei, Poutanen, Matti, Huhtaniemi, Ilpo
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxysteroid Dehydrogenases - metabolism Animals Biological and medical sciences Birth Cell differentiation Colforsin - pharmacology Cytochrome Cytochrome P450 Cytochromes P450 Dehydrogenase Dehydrogenases Exons Female Fetuses Fundamental and applied biological sciences. Psychology Gene expression Genes Hybridization Hydroxysteroids Immunohistochemistry Leydig cells Leydig Cells - physiology Luteinizing hormone Luteinizing Hormone - physiology Male Mesenchyme Mice Mice, Inbred C57BL Mice, Knockout Neonates Phenotype Receptors Receptors, LH - genetics Relaxin Relaxin-like factor Signal Transduction - physiology Steroidogenesis Steroidogenic acute regulatory protein Testes Testis - growth & development Testis - pathology Testis - physiology Testosterone Testosterone - biosynthesis Thrombospondins - genetics Vertebrates: endocrinology
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