Validation of coronary flow reserve measurements by thermodilution in clinical practice
Background Coronary flow reserve (CFR) and fractional flow reserve (FFR) provide complementary information on the coronary circulation. Using a pressure wire, it is possible to calculate CFR by thermodilution (CFRthermo), so that FFR and CFR can be measured with a single guide wire. The present mult...
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Veröffentlicht in: | European heart journal 2004-02, Vol.25 (3), p.219-223 |
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creator | Barbato, Emanuele Aarnoudse, Wilbert Aengevaeren, Wim R. Werner, Gerald Klauss, Volker Bojara, Waldemar Herzfeld, Istvan Oldroyd, Keith G. Pijls, Nico H.J. De Bruyne, Bernard |
description | Background Coronary flow reserve (CFR) and fractional flow reserve (FFR) provide complementary information on the coronary circulation. Using a pressure wire, it is possible to calculate CFR by thermodilution (CFRthermo), so that FFR and CFR can be measured with a single guide wire. The present multicentric study was performed to compare the feasibility of CFRthermoobtained with an improved algorithm and a standardized injection technique and its agreement with Doppler-derived CFR (CFRDoppler). Methods and results In 86 patients with coronary artery disease recruited during 1 week in eight centres FFR, CFRthermoand CFRDopplerwere measured. FFR could be obtained in all patients (100%). An optimal CFRDopplercould be obtained in 69% of the patients. CFRthermocould be obtained in 97% of the patients. A significant correlation was found between CFRDopplerand CFRthermo(r=0.79, P |
doi_str_mv | 10.1016/j.ehj.2003.11.009 |
format | Article |
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Using a pressure wire, it is possible to calculate CFR by thermodilution (CFRthermo), so that FFR and CFR can be measured with a single guide wire. The present multicentric study was performed to compare the feasibility of CFRthermoobtained with an improved algorithm and a standardized injection technique and its agreement with Doppler-derived CFR (CFRDoppler). Methods and results In 86 patients with coronary artery disease recruited during 1 week in eight centres FFR, CFRthermoand CFRDopplerwere measured. FFR could be obtained in all patients (100%). An optimal CFRDopplercould be obtained in 69% of the patients. CFRthermocould be obtained in 97% of the patients. A significant correlation was found between CFRDopplerand CFRthermo(r=0.79, P<0.0001) but CFRthermotended to be higher than CFRDoppler. Conclusions In a setting close to ‘real world’ practice, this multicentric study confirms the feasibility and reliability of thermodilution-derived CFR. In addition, the safety and the swiftness of assessing FFR and CFR with one single guide wire makes the latter a unique clinical tool for the evaluation of the coronary circulation.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1016/j.ehj.2003.11.009</identifier><identifier>PMID: 14972422</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Biological and medical sciences ; Cardiology. Vascular system ; Coronary artery disease ; Coronary Circulation - physiology ; Coronary flow reserve ; Coronary heart disease ; Feasibility Studies ; Fractional flow reserve ; Heart ; Humans ; Ischaemia ; Medical sciences ; Thermodilution ; Thermodilution - methods ; Ultrasonography, Doppler</subject><ispartof>European heart journal, 2004-02, Vol.25 (3), p.219-223</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Feb 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-4439f6a673754dcb26668da091fe9ac2301b5f007ee279961988750e8f68f26f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15480849$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14972422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barbato, Emanuele</creatorcontrib><creatorcontrib>Aarnoudse, Wilbert</creatorcontrib><creatorcontrib>Aengevaeren, Wim R.</creatorcontrib><creatorcontrib>Werner, Gerald</creatorcontrib><creatorcontrib>Klauss, Volker</creatorcontrib><creatorcontrib>Bojara, Waldemar</creatorcontrib><creatorcontrib>Herzfeld, Istvan</creatorcontrib><creatorcontrib>Oldroyd, Keith G.</creatorcontrib><creatorcontrib>Pijls, Nico H.J.</creatorcontrib><creatorcontrib>De Bruyne, Bernard</creatorcontrib><creatorcontrib>Week 25 study group</creatorcontrib><title>Validation of coronary flow reserve measurements by thermodilution in clinical practice</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Background Coronary flow reserve (CFR) and fractional flow reserve (FFR) provide complementary information on the coronary circulation. Using a pressure wire, it is possible to calculate CFR by thermodilution (CFRthermo), so that FFR and CFR can be measured with a single guide wire. The present multicentric study was performed to compare the feasibility of CFRthermoobtained with an improved algorithm and a standardized injection technique and its agreement with Doppler-derived CFR (CFRDoppler). Methods and results In 86 patients with coronary artery disease recruited during 1 week in eight centres FFR, CFRthermoand CFRDopplerwere measured. FFR could be obtained in all patients (100%). An optimal CFRDopplercould be obtained in 69% of the patients. CFRthermocould be obtained in 97% of the patients. A significant correlation was found between CFRDopplerand CFRthermo(r=0.79, P<0.0001) but CFRthermotended to be higher than CFRDoppler. Conclusions In a setting close to ‘real world’ practice, this multicentric study confirms the feasibility and reliability of thermodilution-derived CFR. In addition, the safety and the swiftness of assessing FFR and CFR with one single guide wire makes the latter a unique clinical tool for the evaluation of the coronary circulation.</description><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary artery disease</subject><subject>Coronary Circulation - physiology</subject><subject>Coronary flow reserve</subject><subject>Coronary heart disease</subject><subject>Feasibility Studies</subject><subject>Fractional flow reserve</subject><subject>Heart</subject><subject>Humans</subject><subject>Ischaemia</subject><subject>Medical sciences</subject><subject>Thermodilution</subject><subject>Thermodilution - methods</subject><subject>Ultrasonography, Doppler</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM1u1DAURi0EosPAA7BBERLsEnwd27GXUAFFqoAFPyM2lse5Vj0k8dROgL49ns6ISqy88PmOrg4hT4E2QEG-2jV4tWsYpW0D0FCq75EVCMZqLbm4T1YUtKilVJsz8ijnHaVUSZAPyRlw3THO2Ip8_2aH0Ns5xKmKvnIxxcmmm8oP8XeVMGP6hdWINi8JR5zmXG1vqvkK0xj7MCy3uzBVbghTcHao9sm6OTh8TB54O2R8cnrX5Ou7t1_OL-rLT-8_nL--rJ0QMNect9pLK7u2E7x3WybLub2lGjxq61hLYSs8pR0i67SWoJXqBEXlpfJM-nZNXh69-xSvF8yzGUN2OAx2wrhkoyh0XBT_mjz_D9zFJU3lNsNAcA1FXSA4Qi7FnBN6s09hLD0MUHNIbnamJDeH5AbAlORl8-wkXrYj9neLU-MCvDgBNpdEPtnJhXzHCa6o4gdRfeRCnvHPv3-bfprbPuZi88N81Fpt-BtpPrd_ARWvmTM</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Barbato, Emanuele</creator><creator>Aarnoudse, Wilbert</creator><creator>Aengevaeren, Wim R.</creator><creator>Werner, Gerald</creator><creator>Klauss, Volker</creator><creator>Bojara, Waldemar</creator><creator>Herzfeld, Istvan</creator><creator>Oldroyd, Keith G.</creator><creator>Pijls, Nico H.J.</creator><creator>De Bruyne, Bernard</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>Validation of coronary flow reserve measurements by thermodilution in clinical practice</title><author>Barbato, Emanuele ; Aarnoudse, Wilbert ; Aengevaeren, Wim R. ; Werner, Gerald ; Klauss, Volker ; Bojara, Waldemar ; Herzfeld, Istvan ; Oldroyd, Keith G. ; Pijls, Nico H.J. ; De Bruyne, Bernard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-4439f6a673754dcb26668da091fe9ac2301b5f007ee279961988750e8f68f26f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary artery disease</topic><topic>Coronary Circulation - physiology</topic><topic>Coronary flow reserve</topic><topic>Coronary heart disease</topic><topic>Feasibility Studies</topic><topic>Fractional flow reserve</topic><topic>Heart</topic><topic>Humans</topic><topic>Ischaemia</topic><topic>Medical sciences</topic><topic>Thermodilution</topic><topic>Thermodilution - methods</topic><topic>Ultrasonography, Doppler</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barbato, Emanuele</creatorcontrib><creatorcontrib>Aarnoudse, Wilbert</creatorcontrib><creatorcontrib>Aengevaeren, Wim R.</creatorcontrib><creatorcontrib>Werner, Gerald</creatorcontrib><creatorcontrib>Klauss, Volker</creatorcontrib><creatorcontrib>Bojara, Waldemar</creatorcontrib><creatorcontrib>Herzfeld, Istvan</creatorcontrib><creatorcontrib>Oldroyd, Keith G.</creatorcontrib><creatorcontrib>Pijls, Nico H.J.</creatorcontrib><creatorcontrib>De Bruyne, Bernard</creatorcontrib><creatorcontrib>Week 25 study group</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barbato, Emanuele</au><au>Aarnoudse, Wilbert</au><au>Aengevaeren, Wim R.</au><au>Werner, Gerald</au><au>Klauss, Volker</au><au>Bojara, Waldemar</au><au>Herzfeld, Istvan</au><au>Oldroyd, Keith G.</au><au>Pijls, Nico H.J.</au><au>De Bruyne, Bernard</au><aucorp>Week 25 study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validation of coronary flow reserve measurements by thermodilution in clinical practice</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>25</volume><issue>3</issue><spage>219</spage><epage>223</epage><pages>219-223</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Background Coronary flow reserve (CFR) and fractional flow reserve (FFR) provide complementary information on the coronary circulation. Using a pressure wire, it is possible to calculate CFR by thermodilution (CFRthermo), so that FFR and CFR can be measured with a single guide wire. The present multicentric study was performed to compare the feasibility of CFRthermoobtained with an improved algorithm and a standardized injection technique and its agreement with Doppler-derived CFR (CFRDoppler). Methods and results In 86 patients with coronary artery disease recruited during 1 week in eight centres FFR, CFRthermoand CFRDopplerwere measured. FFR could be obtained in all patients (100%). An optimal CFRDopplercould be obtained in 69% of the patients. CFRthermocould be obtained in 97% of the patients. A significant correlation was found between CFRDopplerand CFRthermo(r=0.79, P<0.0001) but CFRthermotended to be higher than CFRDoppler. Conclusions In a setting close to ‘real world’ practice, this multicentric study confirms the feasibility and reliability of thermodilution-derived CFR. In addition, the safety and the swiftness of assessing FFR and CFR with one single guide wire makes the latter a unique clinical tool for the evaluation of the coronary circulation.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>14972422</pmid><doi>10.1016/j.ehj.2003.11.009</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Biological and medical sciences Cardiology. Vascular system Coronary artery disease Coronary Circulation - physiology Coronary flow reserve Coronary heart disease Feasibility Studies Fractional flow reserve Heart Humans Ischaemia Medical sciences Thermodilution Thermodilution - methods Ultrasonography, Doppler |
title | Validation of coronary flow reserve measurements by thermodilution in clinical practice |
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