Validation of coronary flow reserve measurements by thermodilution in clinical practice

Background Coronary flow reserve (CFR) and fractional flow reserve (FFR) provide complementary information on the coronary circulation. Using a pressure wire, it is possible to calculate CFR by thermodilution (CFRthermo), so that FFR and CFR can be measured with a single guide wire. The present mult...

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Veröffentlicht in:European heart journal 2004-02, Vol.25 (3), p.219-223
Hauptverfasser: Barbato, Emanuele, Aarnoudse, Wilbert, Aengevaeren, Wim R., Werner, Gerald, Klauss, Volker, Bojara, Waldemar, Herzfeld, Istvan, Oldroyd, Keith G., Pijls, Nico H.J., De Bruyne, Bernard
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container_end_page 223
container_issue 3
container_start_page 219
container_title European heart journal
container_volume 25
creator Barbato, Emanuele
Aarnoudse, Wilbert
Aengevaeren, Wim R.
Werner, Gerald
Klauss, Volker
Bojara, Waldemar
Herzfeld, Istvan
Oldroyd, Keith G.
Pijls, Nico H.J.
De Bruyne, Bernard
description Background Coronary flow reserve (CFR) and fractional flow reserve (FFR) provide complementary information on the coronary circulation. Using a pressure wire, it is possible to calculate CFR by thermodilution (CFRthermo), so that FFR and CFR can be measured with a single guide wire. The present multicentric study was performed to compare the feasibility of CFRthermoobtained with an improved algorithm and a standardized injection technique and its agreement with Doppler-derived CFR (CFRDoppler). Methods and results In 86 patients with coronary artery disease recruited during 1 week in eight centres FFR, CFRthermoand CFRDopplerwere measured. FFR could be obtained in all patients (100%). An optimal CFRDopplercould be obtained in 69% of the patients. CFRthermocould be obtained in 97% of the patients. A significant correlation was found between CFRDopplerand CFRthermo(r=0.79, P
doi_str_mv 10.1016/j.ehj.2003.11.009
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Using a pressure wire, it is possible to calculate CFR by thermodilution (CFRthermo), so that FFR and CFR can be measured with a single guide wire. The present multicentric study was performed to compare the feasibility of CFRthermoobtained with an improved algorithm and a standardized injection technique and its agreement with Doppler-derived CFR (CFRDoppler). Methods and results In 86 patients with coronary artery disease recruited during 1 week in eight centres FFR, CFRthermoand CFRDopplerwere measured. FFR could be obtained in all patients (100%). An optimal CFRDopplercould be obtained in 69% of the patients. CFRthermocould be obtained in 97% of the patients. A significant correlation was found between CFRDopplerand CFRthermo(r=0.79, P&lt;0.0001) but CFRthermotended to be higher than CFRDoppler. Conclusions In a setting close to ‘real world’ practice, this multicentric study confirms the feasibility and reliability of thermodilution-derived CFR. In addition, the safety and the swiftness of assessing FFR and CFR with one single guide wire makes the latter a unique clinical tool for the evaluation of the coronary circulation.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1016/j.ehj.2003.11.009</identifier><identifier>PMID: 14972422</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Biological and medical sciences ; Cardiology. Vascular system ; Coronary artery disease ; Coronary Circulation - physiology ; Coronary flow reserve ; Coronary heart disease ; Feasibility Studies ; Fractional flow reserve ; Heart ; Humans ; Ischaemia ; Medical sciences ; Thermodilution ; Thermodilution - methods ; Ultrasonography, Doppler</subject><ispartof>European heart journal, 2004-02, Vol.25 (3), p.219-223</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Feb 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-4439f6a673754dcb26668da091fe9ac2301b5f007ee279961988750e8f68f26f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=15480849$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14972422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barbato, Emanuele</creatorcontrib><creatorcontrib>Aarnoudse, Wilbert</creatorcontrib><creatorcontrib>Aengevaeren, Wim R.</creatorcontrib><creatorcontrib>Werner, Gerald</creatorcontrib><creatorcontrib>Klauss, Volker</creatorcontrib><creatorcontrib>Bojara, Waldemar</creatorcontrib><creatorcontrib>Herzfeld, Istvan</creatorcontrib><creatorcontrib>Oldroyd, Keith G.</creatorcontrib><creatorcontrib>Pijls, Nico H.J.</creatorcontrib><creatorcontrib>De Bruyne, Bernard</creatorcontrib><creatorcontrib>Week 25 study group</creatorcontrib><title>Validation of coronary flow reserve measurements by thermodilution in clinical practice</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Background Coronary flow reserve (CFR) and fractional flow reserve (FFR) provide complementary information on the coronary circulation. Using a pressure wire, it is possible to calculate CFR by thermodilution (CFRthermo), so that FFR and CFR can be measured with a single guide wire. The present multicentric study was performed to compare the feasibility of CFRthermoobtained with an improved algorithm and a standardized injection technique and its agreement with Doppler-derived CFR (CFRDoppler). Methods and results In 86 patients with coronary artery disease recruited during 1 week in eight centres FFR, CFRthermoand CFRDopplerwere measured. FFR could be obtained in all patients (100%). An optimal CFRDopplercould be obtained in 69% of the patients. CFRthermocould be obtained in 97% of the patients. A significant correlation was found between CFRDopplerand CFRthermo(r=0.79, P&lt;0.0001) but CFRthermotended to be higher than CFRDoppler. Conclusions In a setting close to ‘real world’ practice, this multicentric study confirms the feasibility and reliability of thermodilution-derived CFR. In addition, the safety and the swiftness of assessing FFR and CFR with one single guide wire makes the latter a unique clinical tool for the evaluation of the coronary circulation.</description><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary artery disease</subject><subject>Coronary Circulation - physiology</subject><subject>Coronary flow reserve</subject><subject>Coronary heart disease</subject><subject>Feasibility Studies</subject><subject>Fractional flow reserve</subject><subject>Heart</subject><subject>Humans</subject><subject>Ischaemia</subject><subject>Medical sciences</subject><subject>Thermodilution</subject><subject>Thermodilution - methods</subject><subject>Ultrasonography, Doppler</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM1u1DAURi0EosPAA7BBERLsEnwd27GXUAFFqoAFPyM2lse5Vj0k8dROgL49ns6ISqy88PmOrg4hT4E2QEG-2jV4tWsYpW0D0FCq75EVCMZqLbm4T1YUtKilVJsz8ijnHaVUSZAPyRlw3THO2Ip8_2aH0Ns5xKmKvnIxxcmmm8oP8XeVMGP6hdWINi8JR5zmXG1vqvkK0xj7MCy3uzBVbghTcHao9sm6OTh8TB54O2R8cnrX5Ou7t1_OL-rLT-8_nL--rJ0QMNect9pLK7u2E7x3WybLub2lGjxq61hLYSs8pR0i67SWoJXqBEXlpfJM-nZNXh69-xSvF8yzGUN2OAx2wrhkoyh0XBT_mjz_D9zFJU3lNsNAcA1FXSA4Qi7FnBN6s09hLD0MUHNIbnamJDeH5AbAlORl8-wkXrYj9neLU-MCvDgBNpdEPtnJhXzHCa6o4gdRfeRCnvHPv3-bfprbPuZi88N81Fpt-BtpPrd_ARWvmTM</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Barbato, Emanuele</creator><creator>Aarnoudse, Wilbert</creator><creator>Aengevaeren, Wim R.</creator><creator>Werner, Gerald</creator><creator>Klauss, Volker</creator><creator>Bojara, Waldemar</creator><creator>Herzfeld, Istvan</creator><creator>Oldroyd, Keith G.</creator><creator>Pijls, Nico H.J.</creator><creator>De Bruyne, Bernard</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>Validation of coronary flow reserve measurements by thermodilution in clinical practice</title><author>Barbato, Emanuele ; Aarnoudse, Wilbert ; Aengevaeren, Wim R. ; Werner, Gerald ; Klauss, Volker ; Bojara, Waldemar ; Herzfeld, Istvan ; Oldroyd, Keith G. ; Pijls, Nico H.J. ; De Bruyne, Bernard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-4439f6a673754dcb26668da091fe9ac2301b5f007ee279961988750e8f68f26f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary artery disease</topic><topic>Coronary Circulation - physiology</topic><topic>Coronary flow reserve</topic><topic>Coronary heart disease</topic><topic>Feasibility Studies</topic><topic>Fractional flow reserve</topic><topic>Heart</topic><topic>Humans</topic><topic>Ischaemia</topic><topic>Medical sciences</topic><topic>Thermodilution</topic><topic>Thermodilution - methods</topic><topic>Ultrasonography, Doppler</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barbato, Emanuele</creatorcontrib><creatorcontrib>Aarnoudse, Wilbert</creatorcontrib><creatorcontrib>Aengevaeren, Wim R.</creatorcontrib><creatorcontrib>Werner, Gerald</creatorcontrib><creatorcontrib>Klauss, Volker</creatorcontrib><creatorcontrib>Bojara, Waldemar</creatorcontrib><creatorcontrib>Herzfeld, Istvan</creatorcontrib><creatorcontrib>Oldroyd, Keith G.</creatorcontrib><creatorcontrib>Pijls, Nico H.J.</creatorcontrib><creatorcontrib>De Bruyne, Bernard</creatorcontrib><creatorcontrib>Week 25 study group</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barbato, Emanuele</au><au>Aarnoudse, Wilbert</au><au>Aengevaeren, Wim R.</au><au>Werner, Gerald</au><au>Klauss, Volker</au><au>Bojara, Waldemar</au><au>Herzfeld, Istvan</au><au>Oldroyd, Keith G.</au><au>Pijls, Nico H.J.</au><au>De Bruyne, Bernard</au><aucorp>Week 25 study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validation of coronary flow reserve measurements by thermodilution in clinical practice</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>25</volume><issue>3</issue><spage>219</spage><epage>223</epage><pages>219-223</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Background Coronary flow reserve (CFR) and fractional flow reserve (FFR) provide complementary information on the coronary circulation. Using a pressure wire, it is possible to calculate CFR by thermodilution (CFRthermo), so that FFR and CFR can be measured with a single guide wire. The present multicentric study was performed to compare the feasibility of CFRthermoobtained with an improved algorithm and a standardized injection technique and its agreement with Doppler-derived CFR (CFRDoppler). Methods and results In 86 patients with coronary artery disease recruited during 1 week in eight centres FFR, CFRthermoand CFRDopplerwere measured. FFR could be obtained in all patients (100%). An optimal CFRDopplercould be obtained in 69% of the patients. CFRthermocould be obtained in 97% of the patients. A significant correlation was found between CFRDopplerand CFRthermo(r=0.79, P&lt;0.0001) but CFRthermotended to be higher than CFRDoppler. Conclusions In a setting close to ‘real world’ practice, this multicentric study confirms the feasibility and reliability of thermodilution-derived CFR. In addition, the safety and the swiftness of assessing FFR and CFR with one single guide wire makes the latter a unique clinical tool for the evaluation of the coronary circulation.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>14972422</pmid><doi>10.1016/j.ehj.2003.11.009</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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source MEDLINE; Oxford University Press Journals Current; EZB*
subjects Biological and medical sciences
Cardiology. Vascular system
Coronary artery disease
Coronary Circulation - physiology
Coronary flow reserve
Coronary heart disease
Feasibility Studies
Fractional flow reserve
Heart
Humans
Ischaemia
Medical sciences
Thermodilution
Thermodilution - methods
Ultrasonography, Doppler
title Validation of coronary flow reserve measurements by thermodilution in clinical practice
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