Hu1D10 induces apoptosis concurrent with activation of the AKT survival pathway in human chronic lymphocytic leukemia cells

The 1D10 antigen is the target for Hu1D10 (apolizumab), a humanized HLA-DR β-chain–specific antibody that is currently in clinical trials for hematologic malignancies. We demonstrate that Hu1D10 induces caspase-independent apoptosis following secondary cross-linking in primary chronic lymphocytic le...

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Veröffentlicht in:	Blood 2004-03, Vol.103 (5), p.1846-1854
Hauptverfasser:	Mone, Andrew P., Huang, Peng, Pelicano, Helene, Cheney, Carolyn M., Green, Jennifer M., Tso, J. Yun, Johnson, Amy J., Jefferson, Sara, Lin, Thomas S., Byrd, John C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal, Humanized Antineoplastic Agents - pharmacology Apoptosis Blotting, Western Cell Line Cell Line, Tumor Cell Survival Chromones - pharmacology Cytoskeleton - metabolism Electron Transport Enzyme Activation Enzyme Inhibitors - pharmacology Flow Cytometry Free Radical Scavengers - pharmacology Humans Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Membrane Microdomains Mitochondria - metabolism Morpholines - pharmacology Phosphoinositide-3 Kinase Inhibitors Phosphorylation Reactive Oxygen Species Signal Transduction Time Factors
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