Methotrexate therapy in rheumatoid arthritis patients diminishes lectin-induced mononuclear cell proliferation

Methotrexate (MTX) is an anti-folate drug used in cancer chemotherapy because of its anti-proliferative effects. However, it is unclear whether the anti-proliferative effects of MTX contribute to the efficacy of low-dose MTX in the treatment of rheumatoid arthritis (RA). To date, either no change or...

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Veröffentlicht in:	Rheumatology international 1990-01, Vol.10 (4), p.165-169
Hauptverfasser:	Hine, R J, Everson, M P, Hardin, J M, Morgan, S L, Alarcòn, G S, Baggott, J E, Koopman, W J, Krumdieck, C L
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Rheumatoid - drug therapy Cell Division - drug effects Cells, Cultured Culture Media - chemistry Culture Media - pharmacology Deoxyuridine - metabolism DNA - metabolism Female Folic Acid - analysis Folic Acid - pharmacology Humans Lectins - pharmacology Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Male Methotrexate - therapeutic use Middle Aged Phytohemagglutinins - pharmacology Thymidine - metabolism Tritium
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