Mitochondria and the Bcl-2 family proteins in apoptosis signaling pathways
Two main intracellular apoptosis cascades, the receptor and the mitochondria pathway, have been identified. The mitochondrial pathway is controlled by the Bcl-2 proteins. This protein family contains members with either pro- or anti-apoptotic activity. When activated the pro-apoptotic multidomain pr...
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| Veröffentlicht in: | Molecular and cellular biochemistry 2004-01, Vol.256-257 (1-2), p.141-155 |
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| creator | Antonsson, Bruno |
| description | Two main intracellular apoptosis cascades, the receptor and the mitochondria pathway, have been identified. The mitochondrial pathway is controlled by the Bcl-2 proteins. This protein family contains members with either pro- or anti-apoptotic activity. When activated the pro-apoptotic multidomain proteins permeabilized the outer mitochondrial membrane, resulting in the release of proteins from the intermembrane space. Several proteins, including cytochrome c, Smac/DIABLO, HtrA2/Omi, endonuclease G and AIF, normally sequestered in the mitochondria induce or promote apoptosis once released into the cytosol. Although, apoptosis is an essential physiological process in multicellular organisms it is also involved in a wide range of pathological conditions. |
| doi_str_mv | 10.1023/B:MCBI.0000009865.70898.36 |
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| ispartof | Molecular and cellular biochemistry, 2004-01, Vol.256-257 (1-2), p.141-155 |
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| language | eng |
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| subjects | Apoptosis Apoptosis - physiology Caspases - metabolism Humans Mitochondria Mitochondria - physiology Proteins Proto-Oncogene Proteins c-bcl-2 - physiology Signal Transduction - physiology |
| title | Mitochondria and the Bcl-2 family proteins in apoptosis signaling pathways |
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