Endothelin B receptor blockade inhibits dynamics of cell interactions and communications in melanoma cell progression

Phenotypic and genotypic analyses of cutaneous melanoma have identified the endothelin B receptor (ET(B)R) as tumor progression marker, thus representing a potential therapeutic target. Here, we demonstrate that activation of ET(B)R by endothelin-1 (ET-1) and ET-3 leads to loss of expression of the...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2004-02, Vol.64 (4), p.1436-1443
Hauptverfasser:	BAGNATO, Anna, ROSANO, Laura, SPINELLA, Francesca, DI CASTRO, Valeriana, TECCE, Raffaele, NATALI, Pier Giorgio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cadherins - analysis Cell Communication - drug effects Cell Line, Tumor Endothelin B Receptor Antagonists Endothelin-1 - pharmacology Endothelin-3 - pharmacology Enzyme Activation Female Humans Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinases, Membrane-Associated Medical sciences Melanoma - drug therapy Melanoma - metabolism Melanoma - pathology Metalloendopeptidases - metabolism Mice Mice, Nude Mitogen-Activated Protein Kinases - metabolism Pharmacology. Drug treatments Pyrrolidines - pharmacology Receptor, Endothelin B - physiology Signal Transduction Tumors
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