PTH Differentially Regulates Expression of RANKL and OPG

RANKL and OPG gene expressions were measured with and without PTH at different stages of osteoblast development. Mouse stromal cells were cultured in osteoblast differentiating conditions, and RANKL, OPG, COL1, ALP, OC, and PTHRec genes were measured using qRT‐PCR. OPG:RANKL ratios indicate that PTH...

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Veröffentlicht in:	Journal of bone and mineral research 2004-02, Vol.19 (2), p.235-244
Hauptverfasser:	Huang, John C, Sakata, Takeshi, Pfleger, Laura L, Bencsik, Margaret, Halloran, Bernard P, Bikle, Daniel D, Nissenson, Robert A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Carrier Proteins - genetics Cell Differentiation differentiation DNA Primers Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Glycoproteins - genetics Male Membrane Glycoproteins - genetics Mice Mice, Inbred C57BL osteoblast Osteoblasts - metabolism Osteoprotegerin parathyroid hormone Parathyroid Hormone - pharmacology Polymerase Chain Reaction RANK Ligand RANKL Receptor Activator of Nuclear Factor-kappa B Receptors, Cytoplasmic and Nuclear - genetics Receptors, Tumor Necrosis Factor - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Skeleton and joints Vertebrates: osteoarticular system, musculoskeletal system
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