Tyrosine-Derived Quinone Cofactors

Copper amine oxidases (CAOs) and lysyl oxidase (LOX) both contain Cu2+ and quinone cofactors that are derived from a tyrosine residue in the active site. In CAOs, the cofactor is 2,4,5-trihydroxyphenylalanine quinone (TPQ), and in LOX it is lysine tyrosyl quinone (LTQ). The mechanism of oxidative de...

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Veröffentlicht in:	Accounts of chemical research 2004-02, Vol.37 (2), p.131-139
1. Verfasser:	Mure, Minae
Format:	Artikel
Sprache:	eng
Schlagworte:	Amine Oxidase (Copper-Containing) - metabolism Animals Binding Sites Coenzymes - chemistry Coenzymes - metabolism Dihydroxyphenylalanine - analogs & derivatives Dihydroxyphenylalanine - chemistry Dihydroxyphenylalanine - metabolism Humans Lysine - analogs & derivatives Lysine - chemistry Lysine - metabolism Models, Molecular Protein-Lysine 6-Oxidase - metabolism Quinones - chemistry Quinones - metabolism
Online-Zugang:	Volltext
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