Transduction of long-term and mobilized peripheral blood-derived NOD/SCID repopulating cells by foamy virus vectors

Foamy virus (FV) vectors are a promising gene delivery system for use in hematopoietic stem cell gene therapy. Previous FV vector marking studies in the NOD/SCID xenotransplantation model used umbilical cord blood (UCB)-derived SCID repopulating cells (SRCs) that were assayed 5-10 weeks posttranspla...

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Veröffentlicht in:	Human gene therapy 2004, Vol.15 (1), p.87-92
Hauptverfasser:	JOSEPHSON, Neil C, TROBRIDGE, Grant, RUSSELL, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Bone Marrow Cells - metabolism Bone Marrow Transplantation Fundamental and applied biological sciences. Psychology Gene therapy Genetic Therapy Genetic Vectors Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Medical sciences Mice Mice, Inbred NOD Mice, SCID Spumavirus Transduction, Genetic Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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