Modulation of autonomic neuroeffector transmission by nitric oxide in guinea pig ileum
N G-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide synthesis, markedly enhanced tonic (“hump”) responses to transmural stimulatin in guinea pig ileum longitudinal muscle. The enhancement of the hump responses was probably due to a prejunctional effect on substance P-like neurotransmiss...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1990-11, Vol.173 (1), p.106-110 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Gustafsson, Lars E. Wiklund, Claes U. Wikhund, N. Peter Persson, Magnus G. Moncada, Salvador |
| description | N
G-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide synthesis, markedly enhanced tonic (“hump”) responses to transmural stimulatin in guinea pig ileum longitudinal muscle. The enhancement of the hump responses was probably due to a prejunctional effect on substance P-like neurotransmission, since the action of L-NMMA was exerted also in the presence of atropine, and since responses to substance P, a mimic of nerve stimulation, were unaffected by L-NMMA as were cholinergic twitch responses and the overflow of [
3H]choline. Further in support, the hump responses were blocked by the substance P antagonist Spantide. All effects of L-NMMA were stereospecifically reversed by L-arginine. Endogenous nitric oxide thus selectively modulates peptidergic neurotransmission in the gut. |
| doi_str_mv | 10.1016/S0006-291X(05)81028-9 |
| format | Article |
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G-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide synthesis, markedly enhanced tonic (“hump”) responses to transmural stimulatin in guinea pig ileum longitudinal muscle. The enhancement of the hump responses was probably due to a prejunctional effect on substance P-like neurotransmission, since the action of L-NMMA was exerted also in the presence of atropine, and since responses to substance P, a mimic of nerve stimulation, were unaffected by L-NMMA as were cholinergic twitch responses and the overflow of [
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G-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide synthesis, markedly enhanced tonic (“hump”) responses to transmural stimulatin in guinea pig ileum longitudinal muscle. The enhancement of the hump responses was probably due to a prejunctional effect on substance P-like neurotransmission, since the action of L-NMMA was exerted also in the presence of atropine, and since responses to substance P, a mimic of nerve stimulation, were unaffected by L-NMMA as were cholinergic twitch responses and the overflow of [
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Psychology</subject><subject>Guinea Pigs</subject><subject>Ileum - drug effects</subject><subject>Ileum - innervation</subject><subject>Ileum - physiology</subject><subject>In Vitro Techniques</subject><subject>Isomerism</subject><subject>Kinetics</subject><subject>Male</subject><subject>Molecular and cellular biology</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - innervation</subject><subject>Muscle, Smooth - physiology</subject><subject>Myenteric Plexus - drug effects</subject><subject>Myenteric Plexus - physiology</subject><subject>Neurotransmission</subject><subject>Nitric Oxide - metabolism</subject><subject>omega-N-Methylarginine</subject><subject>Substance P - pharmacology</subject><subject>Synaptic Transmission - drug effects</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v3CAQhlHVKt2k_QmRuLRqDk4HDDacqijql5Qqh36oN4TxEFHZsAW7Sv592OyqOeY0h3nmneGBkFMG5wxY9_47AHQN1-z3O5BnigFXjX5GNgw0NJyBeE42_5GX5LiUPwCMiU4fkSPW14gWNuTXtzSuk11CijR5atclxTQHRyOuOaH36JaU6ZJtLHMoZccNdzSGJVco3YYRaYj0Zg0RLd2GGxomXOdX5IW3U8HXh3pCfn76-OPyS3N1_fnr5cVV44TqlwZb3QGMQ6-kQg5KcC-Y1aJ3yDgfOseV5D13LRsG23PlFCLz2kvvbNsja0_I233uNqe_K5bF1CMdTpONmNZiVH2mEAqeBJlUUnK1S5R70OVUSkZvtjnMNt8ZBmYn3jyINzurBqR5EG90nTs9LFiHGcfHqb3p2n9z6Nvi7OSrUBfKI6bbTmjZVu7DnsOq7V_AbIoLGB2OIde_MGMKT1xyD-T1oCw</recordid><startdate>19901130</startdate><enddate>19901130</enddate><creator>Gustafsson, Lars E.</creator><creator>Wiklund, Claes U.</creator><creator>Wikhund, N. 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Peter ; Persson, Magnus G. ; Moncada, Salvador</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-e39600db7858e20842f41a947ce122b6c285272c31bba728c8ee1f9f5fca37e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Acetylcholine - metabolism</topic><topic>Animals</topic><topic>Arginine - analogs & derivatives</topic><topic>Arginine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Choline - metabolism</topic><topic>Electric Stimulation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guinea Pigs</topic><topic>Ileum - drug effects</topic><topic>Ileum - innervation</topic><topic>Ileum - physiology</topic><topic>In Vitro Techniques</topic><topic>Isomerism</topic><topic>Kinetics</topic><topic>Male</topic><topic>Molecular and cellular biology</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - innervation</topic><topic>Muscle, Smooth - physiology</topic><topic>Myenteric Plexus - drug effects</topic><topic>Myenteric Plexus - physiology</topic><topic>Neurotransmission</topic><topic>Nitric Oxide - metabolism</topic><topic>omega-N-Methylarginine</topic><topic>Substance P - pharmacology</topic><topic>Synaptic Transmission - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gustafsson, Lars E.</creatorcontrib><creatorcontrib>Wiklund, Claes U.</creatorcontrib><creatorcontrib>Wikhund, N. Peter</creatorcontrib><creatorcontrib>Persson, Magnus G.</creatorcontrib><creatorcontrib>Moncada, Salvador</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gustafsson, Lars E.</au><au>Wiklund, Claes U.</au><au>Wikhund, N. 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G-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide synthesis, markedly enhanced tonic (“hump”) responses to transmural stimulatin in guinea pig ileum longitudinal muscle. The enhancement of the hump responses was probably due to a prejunctional effect on substance P-like neurotransmission, since the action of L-NMMA was exerted also in the presence of atropine, and since responses to substance P, a mimic of nerve stimulation, were unaffected by L-NMMA as were cholinergic twitch responses and the overflow of [
3H]choline. Further in support, the hump responses were blocked by the substance P antagonist Spantide. All effects of L-NMMA were stereospecifically reversed by L-arginine. Endogenous nitric oxide thus selectively modulates peptidergic neurotransmission in the gut.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>1701630</pmid><doi>10.1016/S0006-291X(05)81028-9</doi><tpages>5</tpages></addata></record> |
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| subjects | Acetylcholine - metabolism Animals Arginine - analogs & derivatives Arginine - pharmacology Biological and medical sciences Cell physiology Choline - metabolism Electric Stimulation Female Fundamental and applied biological sciences. Psychology Guinea Pigs Ileum - drug effects Ileum - innervation Ileum - physiology In Vitro Techniques Isomerism Kinetics Male Molecular and cellular biology Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - innervation Muscle, Smooth - physiology Myenteric Plexus - drug effects Myenteric Plexus - physiology Neurotransmission Nitric Oxide - metabolism omega-N-Methylarginine Substance P - pharmacology Synaptic Transmission - drug effects |
| title | Modulation of autonomic neuroeffector transmission by nitric oxide in guinea pig ileum |
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