STAT4 Is Required for Interleukin-12-induced Chromatin Remodeling of the CD25 Locus

Signal transducer and activator of transcription 4 (STAT4) is a critical mediator of interleukin-12 (IL-12)-stimulated inflammatory immune responses. Despite extensive analysis of the immune responses of STAT4-deficient mice, there is still very little understood about STAT4-dependent gene induction...

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Veröffentlicht in:	The Journal of biological chemistry 2004-02, Vol.279 (8), p.7339-7345
Hauptverfasser:	O'Sullivan, Audrey, Chang, Hua-Chen, Yu, Qing, Kaplan, Mark H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Northern CD25 antigen Cell Membrane - metabolism Cell Separation Chromatin - metabolism CREB-Binding Protein DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Flow Cytometry Histones - metabolism Interleukin-12 - metabolism Mice Mice, Inbred BALB C Models, Biological Nuclear Proteins - metabolism Polymerase Chain Reaction Precipitin Tests Promoter Regions, Genetic Protein Binding Receptors, Interleukin-2 - biosynthesis Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Spleen - cytology STAT4 protein STAT4 Transcription Factor Time Factors Trans-Activators - metabolism Trans-Activators - physiology Transcription, Genetic
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