T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis
To investigate the function of activated T lymphocytes in autoimmune chronic active hepatitis, 7 of 15 T-cell clones from the peripheral blood of 8 patients were studied. These clones showed specificity for liver-membrane antigen with proliferation when stimulated by rabbit liver cell membranes. 6 o...
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| Veröffentlicht in: | The Lancet (British edition) 1990-12, Vol.336 (8730), p.1527-1530 |
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| container_title | The Lancet (British edition) |
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| creator | Wen, L. Peakman, M. Lobo-Yeo, A. Vergani, D. Mowat, A.P. Mieli-Vergani McFarlane, B.M. |
| description | To investigate the function of activated T lymphocytes in autoimmune chronic active hepatitis, 7 of 15 T-cell clones from the peripheral blood of 8 patients were studied. These clones showed specificity for liver-membrane antigen with proliferation when stimulated by rabbit liver cell membranes. 6 of these clones reacted with liver-specific lipoprotein complex, and 1 clone (and 3 subclones) responded to the asialoglycoprotein receptor (ASGPR), both known targets of immune attack in autoimmune chronic active hepatitis. 2 of these clones stimulated autologous B lymphocytes to produce liver-membrane-specific autoantibodies and antibody to the ASG PR. These results suggest that liver-membrane-specific activated T lymphocytes in peripheral blood may be important in the autoimmune attack of chronic active hepatitis. |
| doi_str_mv | 10.1016/0140-6736(90)93306-A |
| format | Article |
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These clones showed specificity for liver-membrane antigen with proliferation when stimulated by rabbit liver cell membranes. 6 of these clones reacted with liver-specific lipoprotein complex, and 1 clone (and 3 subclones) responded to the asialoglycoprotein receptor (ASGPR), both known targets of immune attack in autoimmune chronic active hepatitis. 2 of these clones stimulated autologous B lymphocytes to produce liver-membrane-specific autoantibodies and antibody to the ASG PR. These results suggest that liver-membrane-specific activated T lymphocytes in peripheral blood may be important in the autoimmune attack of chronic active hepatitis.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/0140-6736(90)93306-A</identifier><identifier>PMID: 1979365</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Adolescent ; Autoantibodies - immunology ; Autoantibodies - physiology ; Autoimmune Diseases - immunology ; Biological and medical sciences ; Blood ; Cell Division ; Child ; Child, Preschool ; Clone Cells - immunology ; Female ; Gastroenterology. Liver. Pancreas. 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| subjects | Adolescent Autoantibodies - immunology Autoantibodies - physiology Autoimmune Diseases - immunology Biological and medical sciences Blood Cell Division Child Child, Preschool Clone Cells - immunology Female Gastroenterology. Liver. Pancreas. Abdomen Hepatitis Hepatitis, Chronic - blood Hepatitis, Chronic - immunology Humans Liver Lymphocytes Male Medical research Medical sciences Membranes T-Lymphocytes - physiology |
| title | T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis |
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