Regulation of thyroid hormone receptor and c-erbA mRNA levels by butyrate in neuroblastoma (N2A) and glioma (C6) cells

Butyrate produced a biphasic modulation of the thyroid hormone receptor in neuroblastoma N2A cells increasing receptor number by 20–35% at concentrations 0.25–0.75 mM and decreasing receptor levels by 30–55% at 2–4 mM. The half‐life of the receptor, as assessed by its disappearance after incubation...

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Veröffentlicht in:	Journal of neuroscience research 1990-09, Vol.27 (1), p.1-9
Hauptverfasser:	Yusta, B., Ortiz-Caro, J., Bedo, G., Pascual, A., Aranda, Ana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Butyrates - pharmacology Butyric Acid c-erbA mRNAs Cell Division Cell receptors Cell structures and functions Down-Regulation - drug effects Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic - drug effects glioma Glioma - pathology Half-Life histone acetylation Histones - metabolism Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Mice Molecular and cellular biology Neoplasm Proteins - metabolism neuroblastoma Neuroblastoma - pathology Poly A - biosynthesis Protein Processing, Post-Translational - drug effects Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - genetics Receptors, Thyroid Hormone - biosynthesis Receptors, Thyroid Hormone - genetics RNA, Messenger - biosynthesis RNA, Neoplasm - biosynthesis thyroid hormone receptor Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism Up-Regulation - drug effects
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