Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors

N10-Propargyl-5,8-dideazafolic acid (CB3717) and 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI-198,583) are potent folate-based inhibitors of thymidylate synthase. We studied the membrane transport and the growth-inhibitory effects of the two thymidylate synthase inhibitors on human C...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1990-12, Vol.50 (23), p.7544-7548
Hauptverfasser:	JANSEN, G, SCHORNAGEL, J. H, WESTERHOF, G. R, RIJKSEN, G, NEWELL, D. R, JACKMAN, A. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacokinetics Biological and medical sciences Biological Transport Cell Division - drug effects Cells, Cultured Drug Carriers folic acid Folic Acid - analogs & derivatives Folic Acid - metabolism Folic Acid - pharmacokinetics Folic Acid Antagonists - pharmacokinetics General aspects Humans In Vitro Techniques leukemia Leukemia - metabolism Medical sciences Methotrexate Pharmacology. Drug treatments Quinazolines - pharmacokinetics Thymidylate Synthase - antagonists & inhibitors
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