Checkpoint-mediated control of replisome-fork association and signalling in response to replication pausing

The replication checkpoint controls the integrity of replicating chromosomes by stabilizing stalled forks, thus preventing the accumulation of abnormal replication and recombination intermediates that contribute to genome instability. Checkpoint-defective cells are susceptible to rearrangements at c...

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Veröffentlicht in:	Oncogene 2004-02, Vol.23 (6), p.1206-1213
Hauptverfasser:	Lucca, Chiara, Vanoli, Fabio, Cotta-Ramusino, Cecilia, Pellicioli, Achille, Liberi, Giordano, Haber, James, Foiani, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biological and medical sciences Cancer Cell Biology Cell cycle Cell Cycle Proteins Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Checkpoint Kinase 2 Chromosome Aberrations Chromosomes Ddc2 protein DNA damage DNA Replication - genetics DNA-directed DNA polymerase DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Enzymes Filaments Fragile sites Fundamental and applied biological sciences. Psychology Gene Rearrangement Genetic Predisposition to Disease - genetics Genomes Genomic instability Human Genetics Humans Intermediates Internal Medicine Kinases Medicine Medicine & Public Health Molecular and cellular biology Neoplasms - genetics Oncology original-paper Protein-Serine-Threonine Kinases - genetics Recombination replication factor A Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Signal Transduction - genetics
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