Synaptic transmission in human neocortex removed for treatment of intractable epilepsy in children

Synaptic transmission to pyramidal cells was studied in slices of neocortex resected from infants and children (n = 10, age 8 months to 13 years) undergoing surgical treatment for intractable epilepsy. Most specimens were from the least abnormal area of the resection. Stable intracellular recordings...

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Veröffentlicht in:	Annals of neurology 1990-10, Vol.28 (4), p.503-511
Hauptverfasser:	Wuarin, Jean-Pierre, Kim, Yang In, Cepeda, Carlos, Tasker, Jeffrey G., Walsh, John P., Peacock, Warwick J., Buchwald, Nathaniel A., Dudek, F. Edward
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-5-phosphonovalerate - pharmacology Adolescent Bicuculline - pharmacology Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Child Child, Preschool Epilepsy - physiopathology Epilepsy - surgery Female Fundamental and applied biological sciences. Psychology GABA Antagonists Humans Infant Kynurenic Acid - pharmacology Male Membrane Potentials - drug effects N-Methylaspartate - antagonists & inhibitors Psychosurgery Pyramidal Tracts - physiopathology Spasms, Infantile - physiopathology Spasms, Infantile - surgery Synapses - drug effects Synapses - physiology Synaptic Transmission - drug effects Vertebrates: nervous system and sense organs
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