Effect of active immunization of pony mares against recombinant porcine inhibin alpha subunit on ovarian follicular development and plasma steroids and gonadotropins
Two pony mares were immunized against recombinant porcine inhibin α subunit three times with 39 day intervals. Clinical findings and endocrinological changes before immunization were taken as the control. The first significant rise in the anti-inhibin titre (P
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2004, Vol.66(1), pp.31-35 |
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| container_title | Journal of Veterinary Medical Science |
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| creator | Derar, R.I. (Iwate Univ., Morioka (Japan). Faculty of Agriculture) Maeda, Y Hoque, M.S Osawa, T Watanabe, G Taya, K Miyake, Y |
| description | Two pony mares were immunized against recombinant porcine inhibin α subunit three times with 39 day intervals. Clinical findings and endocrinological changes before immunization were taken as the control. The first significant rise in the anti-inhibin titre (P |
| doi_str_mv | 10.1292/jvms.66.31 |
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(Iwate Univ., Morioka (Japan). Faculty of Agriculture) ; Maeda, Y ; Hoque, M.S ; Osawa, T ; Watanabe, G ; Taya, K ; Miyake, Y</creator><creatorcontrib>Derar, R.I. (Iwate Univ., Morioka (Japan). Faculty of Agriculture) ; Maeda, Y ; Hoque, M.S ; Osawa, T ; Watanabe, G ; Taya, K ; Miyake, Y</creatorcontrib><description>Two pony mares were immunized against recombinant porcine inhibin α subunit three times with 39 day intervals. Clinical findings and endocrinological changes before immunization were taken as the control. The first significant rise in the anti-inhibin titre (P<0.05) in the circulation was found 27 days after the first injection. Maximum binding activity was reached by the 12th day after the second booster dose. The number of small, medium and large sized follicles had increased significantly compared to before immunization (11.75 ± 4.30, 2.75 ± 0.69 and 2.51 ± 0.63 vs 6.50 ± 1.43, 1.83 ± 0.44 and 1.33 ± 0.38, respectively), but the ovulation rate remained unchanged after immunization. The average plasma concentration of FSH and estradiol-17β during the estrous cycle increased significantly (P<0.05) after immunization. These results suggest that immunization against inhibin is a useful tool to increase the number of ovarian follicles during the estrous cycle of pony mares. Moreover, the present study supported the concept that inhibin plays a major role in the control of follicular growth through its inhibitory effect on FSH secretion synergistically with steroid hormones.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.66.31</identifier><identifier>PMID: 14960807</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Animals ; Estradiol - blood ; Female ; follicular development ; FSH ; Horses - immunology ; IMMUNIZATION ; Immunization - veterinary ; inhibin ; Inhibins - blood ; Inhibins - immunology ; Inhibins - pharmacokinetics ; Inhibins - pharmacology ; mare ; MARES ; Ovarian Follicle - growth & development ; Ovarian Follicle - immunology ; OVARIAN FOLLICLES ; Ovulation - drug effects ; Ovulation - immunology ; PEPTIDES</subject><ispartof>Journal of Veterinary Medical Science, 2004, Vol.66(1), pp.31-35</ispartof><rights>2004 by the Japanese Society of Veterinary Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c588t-aaa1e030763ffcfeff6f8997a63fb2ac7e4a39ac00ddae7880ad8f45981ceaa33</citedby><cites>FETCH-LOGICAL-c588t-aaa1e030763ffcfeff6f8997a63fb2ac7e4a39ac00ddae7880ad8f45981ceaa33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14960807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Derar, R.I. (Iwate Univ., Morioka (Japan). Faculty of Agriculture)</creatorcontrib><creatorcontrib>Maeda, Y</creatorcontrib><creatorcontrib>Hoque, M.S</creatorcontrib><creatorcontrib>Osawa, T</creatorcontrib><creatorcontrib>Watanabe, G</creatorcontrib><creatorcontrib>Taya, K</creatorcontrib><creatorcontrib>Miyake, Y</creatorcontrib><title>Effect of active immunization of pony mares against recombinant porcine inhibin alpha subunit on ovarian follicular development and plasma steroids and gonadotropins</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>Two pony mares were immunized against recombinant porcine inhibin α subunit three times with 39 day intervals. Clinical findings and endocrinological changes before immunization were taken as the control. The first significant rise in the anti-inhibin titre (P<0.05) in the circulation was found 27 days after the first injection. Maximum binding activity was reached by the 12th day after the second booster dose. The number of small, medium and large sized follicles had increased significantly compared to before immunization (11.75 ± 4.30, 2.75 ± 0.69 and 2.51 ± 0.63 vs 6.50 ± 1.43, 1.83 ± 0.44 and 1.33 ± 0.38, respectively), but the ovulation rate remained unchanged after immunization. The average plasma concentration of FSH and estradiol-17β during the estrous cycle increased significantly (P<0.05) after immunization. These results suggest that immunization against inhibin is a useful tool to increase the number of ovarian follicles during the estrous cycle of pony mares. Moreover, the present study supported the concept that inhibin plays a major role in the control of follicular growth through its inhibitory effect on FSH secretion synergistically with steroid hormones.</description><subject>Animals</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>follicular development</subject><subject>FSH</subject><subject>Horses - immunology</subject><subject>IMMUNIZATION</subject><subject>Immunization - veterinary</subject><subject>inhibin</subject><subject>Inhibins - blood</subject><subject>Inhibins - immunology</subject><subject>Inhibins - pharmacokinetics</subject><subject>Inhibins - pharmacology</subject><subject>mare</subject><subject>MARES</subject><subject>Ovarian Follicle - growth & development</subject><subject>Ovarian Follicle - immunology</subject><subject>OVARIAN FOLLICLES</subject><subject>Ovulation - drug effects</subject><subject>Ovulation - immunology</subject><subject>PEPTIDES</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU2P0zAQhi0EYrsLF-4gnzis1GLHSZycEFotX1oJDnC2ps64deXYwXYqLf-H_4lLqnKx5XeeeUbyEPKKsw2v-urd4TimTdtuBH9CVlzUci1r0T8lK9bzdi2rhl2R65QOjFW8bvvn5IrXfcs6Jlfkz70xqDMNhoLO9ojUjuPs7W_INvhTPAX_SEeImCjswPqUaUQdxq314HMpR219afN7WyIKbtoDTfO2SIq2KI4QLXhqgnNWzw4iHfCILkwjln7wA50cpLE0ZYzBDulftgsehpBjmMrIF-SZAZfw5fm-IT8_3v-4-7x--Pbpy92Hh7Vuui6vAYAjE0y2whht0JjWdH0voby3FWiJNYgeNGPDACi7jsHQmbrpO64RQIgb8nbxTjH8mjFlNdqk0TnwGOakOsabmktZwNsF1DGkFNGoKdrySY-KM3VaijotRbWtErzAb87WeTvi8B89b6EA7xfgkDLs8AJAzFY7vLj4cgh-qeg9RIW-GF4vBgNBwS7apL5-rxhrGGO17MVfwS6u5Q</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Derar, R.I. (Iwate Univ., Morioka (Japan). Faculty of Agriculture)</creator><creator>Maeda, Y</creator><creator>Hoque, M.S</creator><creator>Osawa, T</creator><creator>Watanabe, G</creator><creator>Taya, K</creator><creator>Miyake, Y</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040101</creationdate><title>Effect of active immunization of pony mares against recombinant porcine inhibin alpha subunit on ovarian follicular development and plasma steroids and gonadotropins</title><author>Derar, R.I. (Iwate Univ., Morioka (Japan). Faculty of Agriculture) ; Maeda, Y ; Hoque, M.S ; Osawa, T ; Watanabe, G ; Taya, K ; Miyake, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c588t-aaa1e030763ffcfeff6f8997a63fb2ac7e4a39ac00ddae7880ad8f45981ceaa33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>follicular development</topic><topic>FSH</topic><topic>Horses - immunology</topic><topic>IMMUNIZATION</topic><topic>Immunization - veterinary</topic><topic>inhibin</topic><topic>Inhibins - blood</topic><topic>Inhibins - immunology</topic><topic>Inhibins - pharmacokinetics</topic><topic>Inhibins - pharmacology</topic><topic>mare</topic><topic>MARES</topic><topic>Ovarian Follicle - growth & development</topic><topic>Ovarian Follicle - immunology</topic><topic>OVARIAN FOLLICLES</topic><topic>Ovulation - drug effects</topic><topic>Ovulation - immunology</topic><topic>PEPTIDES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Derar, R.I. (Iwate Univ., Morioka (Japan). Faculty of Agriculture)</creatorcontrib><creatorcontrib>Maeda, Y</creatorcontrib><creatorcontrib>Hoque, M.S</creatorcontrib><creatorcontrib>Osawa, T</creatorcontrib><creatorcontrib>Watanabe, G</creatorcontrib><creatorcontrib>Taya, K</creatorcontrib><creatorcontrib>Miyake, Y</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Derar, R.I. (Iwate Univ., Morioka (Japan). Faculty of Agriculture)</au><au>Maeda, Y</au><au>Hoque, M.S</au><au>Osawa, T</au><au>Watanabe, G</au><au>Taya, K</au><au>Miyake, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of active immunization of pony mares against recombinant porcine inhibin alpha subunit on ovarian follicular development and plasma steroids and gonadotropins</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>66</volume><issue>1</issue><spage>31</spage><epage>35</epage><pages>31-35</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>Two pony mares were immunized against recombinant porcine inhibin α subunit three times with 39 day intervals. Clinical findings and endocrinological changes before immunization were taken as the control. The first significant rise in the anti-inhibin titre (P<0.05) in the circulation was found 27 days after the first injection. Maximum binding activity was reached by the 12th day after the second booster dose. The number of small, medium and large sized follicles had increased significantly compared to before immunization (11.75 ± 4.30, 2.75 ± 0.69 and 2.51 ± 0.63 vs 6.50 ± 1.43, 1.83 ± 0.44 and 1.33 ± 0.38, respectively), but the ovulation rate remained unchanged after immunization. The average plasma concentration of FSH and estradiol-17β during the estrous cycle increased significantly (P<0.05) after immunization. These results suggest that immunization against inhibin is a useful tool to increase the number of ovarian follicles during the estrous cycle of pony mares. Moreover, the present study supported the concept that inhibin plays a major role in the control of follicular growth through its inhibitory effect on FSH secretion synergistically with steroid hormones.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF VETERINARY SCIENCE</pub><pmid>14960807</pmid><doi>10.1292/jvms.66.31</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Estradiol - blood Female follicular development FSH Horses - immunology IMMUNIZATION Immunization - veterinary inhibin Inhibins - blood Inhibins - immunology Inhibins - pharmacokinetics Inhibins - pharmacology mare MARES Ovarian Follicle - growth & development Ovarian Follicle - immunology OVARIAN FOLLICLES Ovulation - drug effects Ovulation - immunology PEPTIDES |
| title | Effect of active immunization of pony mares against recombinant porcine inhibin alpha subunit on ovarian follicular development and plasma steroids and gonadotropins |
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