Thioredoxin secreted upon ultraviolet A irradiation modulates activities of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in human dermal fibroblasts

Regulation of the balance of matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor (TIMP-2) by thioredoxin (Trx) was investigated in human dermal fibroblasts. Expression and secretion of Trx and Trx reductase 1 (TR1) was increased after ultraviolet (UV) A irradiation. A significant increase in...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2004-03, Vol.423 (1), p.218-226
Hauptverfasser:	Oh, Jang-Hee, Chung, An-Sik, Steinbrenner, Holger, Sies, Helmut, Brenneisen, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Fibroblast Fibroblasts - metabolism Fibroblasts - radiation effects Humans Matrix Metalloproteinase 2 - metabolism MMP-2 Skin - enzymology Skin - metabolism Skin - radiation effects Thioredoxin Thioredoxin reductase Thioredoxins - metabolism Thioredoxins - radiation effects TIMP-2 Tissue Inhibitor of Metalloproteinase-2 - metabolism Ultraviolet Rays UVA irradiation
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