Membrane Type-1 Matrix Metalloproteinase Promotes Human Melanoma Invasion and Growth

Membrane type-I metalloproteinase (MT1-MMP) is a transmembrane metalloproteinase that is critical for tumor cell invasion. MT1-MMP can degrade extracellular matrix (ECM) proteins directly and/or indirectly by activating soluble MMPs such as pro-MMP-2. Although MT1-MMP is upregulated in malignant mel...

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Veröffentlicht in:	Journal of investigative dermatology 2004-01, Vol.122 (1), p.167-176
Hauptverfasser:	Iida, Joji, Wilhelmson, Krista L., Price, Matthew A., Wilson, Christopher M., Pei, Duanqing, Furcht, Leo T., Mccarthy, James B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatible Materials Biological and medical sciences Cell Division Cell Line, Tumor Collagen Collagen Type I Collagen Type IV Dermatology Drug Combinations Enzyme Precursors - genetics Female Fibrosarcoma Gelatinases - genetics growth Humans Injections, Intradermal invasion Laminin Matrix Metalloproteinase 14 Matrix Metalloproteinases, Membrane-Associated Medical sciences melanoma Melanoma - pathology Metalloendopeptidases - genetics Metalloendopeptidases - metabolism Mice Mice, Inbred NOD Neoplasm Invasiveness Neoplasm Transplantation Proteoglycans Skin Neoplasms - pathology Transfection Tumors of the skin and soft tissue. Premalignant lesions
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