Identification of a novel protein complex containing annexin A4, rabphilin and synaptotagmin

Rabphilin is a synaptic vesicle-associated protein proposed to play a role in regulating neurotransmitter release. Here we report the isolation and identification of a novel protein complex containing rabphilin, annexin A4 and synaptotagmin 1. We show that the rabphilin C2B domain interacts directly...

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Veröffentlicht in:	FEBS letters 2004-02, Vol.559 (1), p.13-21
Hauptverfasser:	Willshaw, Angela, Grant, Karen, Yan, Jun, Rockliffe, Nichola, Ambavarapu, Sailaja, Burdyga, Galina, Varro, Andrea, Fukuoka, Shin-Ichi, Gawler, Debra
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Amino Acid Sequence Animals Annexin Annexin A4 - metabolism Annexin A4 - physiology C2 domain Ca 2+-regulated secretion Ca2+-regulated secretion Calcium-Binding Proteins Cells, Cultured ECL, enhanced chemiluminescence Exocytosis GFAP, glial fibrillary acidic protein GST, glutathione S-transferase Macromolecular Substances Membrane Glycoproteins - metabolism Nerve Tissue Proteins - metabolism Neurons - chemistry Neurons - cytology PBS, phosphate-buffered saline PC12 Cells Protein Binding Protein Interaction Mapping rab GTP-Binding Proteins - metabolism Rabphilin Rabphilin-3A Rats Rats, Sprague-Dawley Synaptic Membranes - chemistry Synaptic Vesicles - chemistry Synaptotagmin I Synaptotagmins TFA, trifluoroacetic acid Vesicular Transport Proteins
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