The Effect of a Six-Month Exercise Program on Very Low-Density Lipoprotein Apolipoprotein B Secretion in Type 2 Diabetes
The dyslipidemia and insulin resistance of type 2 diabetes can be improved by aerobic exercise. The effect of 6 months supervised exercise on very low-density lipoprotein (VLDL) apolipoprotein B metabolism was investigated in patients with type 2 diabetes. Moderately obese patients (n = 18) were ran...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2004-02, Vol.89 (2), p.688-694 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | Alam, Saima Stolinski, Michael Pentecost, Claire Boroujerdi, Massoud A. Jones, Richard H. Sonksen, Peter H. Umpleby, A. Margot |
| description | The dyslipidemia and insulin resistance of type 2 diabetes can be improved by aerobic exercise. The effect of 6 months supervised exercise on very low-density lipoprotein (VLDL) apolipoprotein B metabolism was investigated in patients with type 2 diabetes. Moderately obese patients (n = 18) were randomized into supervised (n = 9) and unsupervised (n = 9) exercise groups. All patients were given a training session and a personal exercise program and asked to exercise four times per week at 70% maximal oxygen uptake for 6 months. Patients in the supervised group had a weekly session with an exercise trainer. VLDL apolipoprotein (apo)B metabolism was measured with an infusion of 1-13C leucine before and after 6 months of the exercise program.
Supervised exercise for 6 months resulted in a significant within-group decrease in percent hemoglobin A1c (P < 0.001), body fat (P < 0.004), nonesterified fatty acid (P < 0.04), and triglycerides (P < 0.05) and an increase in insulin sensitivity (P < 0.01). There was a decrease in VLDL apoB pool size (160.8 ± 42.6 to 84.9 ± 23.2 mg, P < 0.01) and VLDL apoB secretion rate (11.3 ± 2.6 to 5.5 ± 2.0 mg/kg·d, P < 0.05) with no change in fractional catabolic rate. In a between-group comparison, the decrease in VLDL apoB secretion rate in the supervised group did not achieve significance. This study demonstrates that in type 2 diabetes, a supervised exercise program reduces VLDL apoB pool size, which may be due to a decrease in VLDL apoB secretion rate. |
| doi_str_mv | 10.1210/jc.2003-031036 |
| format | Article |
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Supervised exercise for 6 months resulted in a significant within-group decrease in percent hemoglobin A1c (P < 0.001), body fat (P < 0.004), nonesterified fatty acid (P < 0.04), and triglycerides (P < 0.05) and an increase in insulin sensitivity (P < 0.01). There was a decrease in VLDL apoB pool size (160.8 ± 42.6 to 84.9 ± 23.2 mg, P < 0.01) and VLDL apoB secretion rate (11.3 ± 2.6 to 5.5 ± 2.0 mg/kg·d, P < 0.05) with no change in fractional catabolic rate. In a between-group comparison, the decrease in VLDL apoB secretion rate in the supervised group did not achieve significance. This study demonstrates that in type 2 diabetes, a supervised exercise program reduces VLDL apoB pool size, which may be due to a decrease in VLDL apoB secretion rate.]]></description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2003-031036</identifier><identifier>PMID: 14764782</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adult ; Aged ; Apolipoproteins B - blood ; Apolipoproteins B - metabolism ; Biological and medical sciences ; Blood Glucose - analysis ; Body Composition ; Diabetes Mellitus - metabolism ; Diabetes Mellitus - pathology ; Diabetes Mellitus - physiopathology ; Diabetes Mellitus - therapy ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes Mellitus, Type 2 - pathology ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes Mellitus, Type 2 - therapy ; Endocrinopathies ; Exercise Therapy ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Insulin Resistance ; Kinetics ; Lipids - blood ; Lipoproteins, VLDL - blood ; Lipoproteins, VLDL - metabolism ; Male ; Medical sciences ; Middle Aged ; Obesity ; Physical Fitness ; Quality of Life ; Time Factors ; Vertebrates: endocrinology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2004-02, Vol.89 (2), p.688-694</ispartof><rights>Copyright © 2004 by The Endocrine Society</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5097-f51b38c0d469d3a3b6e4ea9f2f8241f546a4dcbb8a2475c439c17a7fe69edd1c3</citedby><cites>FETCH-LOGICAL-c5097-f51b38c0d469d3a3b6e4ea9f2f8241f546a4dcbb8a2475c439c17a7fe69edd1c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15482162$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14764782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alam, Saima</creatorcontrib><creatorcontrib>Stolinski, Michael</creatorcontrib><creatorcontrib>Pentecost, Claire</creatorcontrib><creatorcontrib>Boroujerdi, Massoud A.</creatorcontrib><creatorcontrib>Jones, Richard H.</creatorcontrib><creatorcontrib>Sonksen, Peter H.</creatorcontrib><creatorcontrib>Umpleby, A. Margot</creatorcontrib><title>The Effect of a Six-Month Exercise Program on Very Low-Density Lipoprotein Apolipoprotein B Secretion in Type 2 Diabetes</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description><![CDATA[The dyslipidemia and insulin resistance of type 2 diabetes can be improved by aerobic exercise. The effect of 6 months supervised exercise on very low-density lipoprotein (VLDL) apolipoprotein B metabolism was investigated in patients with type 2 diabetes. Moderately obese patients (n = 18) were randomized into supervised (n = 9) and unsupervised (n = 9) exercise groups. All patients were given a training session and a personal exercise program and asked to exercise four times per week at 70% maximal oxygen uptake for 6 months. Patients in the supervised group had a weekly session with an exercise trainer. VLDL apolipoprotein (apo)B metabolism was measured with an infusion of 1-13C leucine before and after 6 months of the exercise program.
Supervised exercise for 6 months resulted in a significant within-group decrease in percent hemoglobin A1c (P < 0.001), body fat (P < 0.004), nonesterified fatty acid (P < 0.04), and triglycerides (P < 0.05) and an increase in insulin sensitivity (P < 0.01). There was a decrease in VLDL apoB pool size (160.8 ± 42.6 to 84.9 ± 23.2 mg, P < 0.01) and VLDL apoB secretion rate (11.3 ± 2.6 to 5.5 ± 2.0 mg/kg·d, P < 0.05) with no change in fractional catabolic rate. In a between-group comparison, the decrease in VLDL apoB secretion rate in the supervised group did not achieve significance. This study demonstrates that in type 2 diabetes, a supervised exercise program reduces VLDL apoB pool size, which may be due to a decrease in VLDL apoB secretion rate.]]></description><subject>Adult</subject><subject>Aged</subject><subject>Apolipoproteins B - blood</subject><subject>Apolipoproteins B - metabolism</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Body Composition</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Diabetes Mellitus - pathology</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Diabetes Mellitus - therapy</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes Mellitus, Type 2 - pathology</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes Mellitus, Type 2 - therapy</subject><subject>Endocrinopathies</subject><subject>Exercise Therapy</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Kinetics</subject><subject>Lipids - blood</subject><subject>Lipoproteins, VLDL - blood</subject><subject>Lipoproteins, VLDL - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Physical Fitness</subject><subject>Quality of Life</subject><subject>Time Factors</subject><subject>Vertebrates: endocrinology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P0zAQhiMEYsvClSPyBW4u_kocH5fd8iEVgbQFcbMcZ0xd0jjYidr-e1yl0nJBWBp7Rnre8WjeonhJyZIySt7u7JIRwjHhlPDqUbGgSpRYUiUfFwtCGMVKsh9XxbOUdoRQIUr-tLiiQlZC1mxRHDdbQCvnwI4oOGTQvT_iz6Eft2h1hGh9AvQ1hp_R7FHo0XeIJ7QOB3wHffJjzv0QhhhG8D26GUL3V_kO3YONMPqsy-XmNABi6M6bBkZIz4snznQJXlze6-Lb-9Xm9iNef_nw6fZmjW1JlMSupA2vLWlFpVpueFOBAKMcczUT1JWiMqK1TVMbJmRpBVeWSiMdVArallp-XbyZ--axfk-QRr33yULXmR7ClHRNaMk5F_8FqVSEEqIyuJxBG0NKEZweot-beNKU6LMpemf12RQ9m5IFry6dp2YP7QN-cSEDry-ASdZ0Lpo-L_6BK0XNaHXmxMwdQjdCTL-66QBRb8F041aTfEQla5z_FiRfBOfgMsvKWQZ9G2z0PQwRUtK7MMU-7_5fc_8BPCu1mA</recordid><startdate>200402</startdate><enddate>200402</enddate><creator>Alam, Saima</creator><creator>Stolinski, Michael</creator><creator>Pentecost, Claire</creator><creator>Boroujerdi, Massoud A.</creator><creator>Jones, Richard H.</creator><creator>Sonksen, Peter H.</creator><creator>Umpleby, A. Margot</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>200402</creationdate><title>The Effect of a Six-Month Exercise Program on Very Low-Density Lipoprotein Apolipoprotein B Secretion in Type 2 Diabetes</title><author>Alam, Saima ; Stolinski, Michael ; Pentecost, Claire ; Boroujerdi, Massoud A. ; Jones, Richard H. ; Sonksen, Peter H. ; Umpleby, A. Margot</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5097-f51b38c0d469d3a3b6e4ea9f2f8241f546a4dcbb8a2475c439c17a7fe69edd1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Apolipoproteins B - blood</topic><topic>Apolipoproteins B - metabolism</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Body Composition</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Diabetes Mellitus - pathology</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Diabetes Mellitus - therapy</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes Mellitus, Type 2 - pathology</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes Mellitus, Type 2 - therapy</topic><topic>Endocrinopathies</topic><topic>Exercise Therapy</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Kinetics</topic><topic>Lipids - blood</topic><topic>Lipoproteins, VLDL - blood</topic><topic>Lipoproteins, VLDL - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Physical Fitness</topic><topic>Quality of Life</topic><topic>Time Factors</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alam, Saima</creatorcontrib><creatorcontrib>Stolinski, Michael</creatorcontrib><creatorcontrib>Pentecost, Claire</creatorcontrib><creatorcontrib>Boroujerdi, Massoud A.</creatorcontrib><creatorcontrib>Jones, Richard H.</creatorcontrib><creatorcontrib>Sonksen, Peter H.</creatorcontrib><creatorcontrib>Umpleby, A. Margot</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alam, Saima</au><au>Stolinski, Michael</au><au>Pentecost, Claire</au><au>Boroujerdi, Massoud A.</au><au>Jones, Richard H.</au><au>Sonksen, Peter H.</au><au>Umpleby, A. Margot</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of a Six-Month Exercise Program on Very Low-Density Lipoprotein Apolipoprotein B Secretion in Type 2 Diabetes</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2004-02</date><risdate>2004</risdate><volume>89</volume><issue>2</issue><spage>688</spage><epage>694</epage><pages>688-694</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract><![CDATA[The dyslipidemia and insulin resistance of type 2 diabetes can be improved by aerobic exercise. The effect of 6 months supervised exercise on very low-density lipoprotein (VLDL) apolipoprotein B metabolism was investigated in patients with type 2 diabetes. Moderately obese patients (n = 18) were randomized into supervised (n = 9) and unsupervised (n = 9) exercise groups. All patients were given a training session and a personal exercise program and asked to exercise four times per week at 70% maximal oxygen uptake for 6 months. Patients in the supervised group had a weekly session with an exercise trainer. VLDL apolipoprotein (apo)B metabolism was measured with an infusion of 1-13C leucine before and after 6 months of the exercise program.
Supervised exercise for 6 months resulted in a significant within-group decrease in percent hemoglobin A1c (P < 0.001), body fat (P < 0.004), nonesterified fatty acid (P < 0.04), and triglycerides (P < 0.05) and an increase in insulin sensitivity (P < 0.01). There was a decrease in VLDL apoB pool size (160.8 ± 42.6 to 84.9 ± 23.2 mg, P < 0.01) and VLDL apoB secretion rate (11.3 ± 2.6 to 5.5 ± 2.0 mg/kg·d, P < 0.05) with no change in fractional catabolic rate. In a between-group comparison, the decrease in VLDL apoB secretion rate in the supervised group did not achieve significance. This study demonstrates that in type 2 diabetes, a supervised exercise program reduces VLDL apoB pool size, which may be due to a decrease in VLDL apoB secretion rate.]]></abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>14764782</pmid><doi>10.1210/jc.2003-031036</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Apolipoproteins B - blood Apolipoproteins B - metabolism Biological and medical sciences Blood Glucose - analysis Body Composition Diabetes Mellitus - metabolism Diabetes Mellitus - pathology Diabetes Mellitus - physiopathology Diabetes Mellitus - therapy Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - physiopathology Diabetes Mellitus, Type 2 - therapy Endocrinopathies Exercise Therapy Female Fundamental and applied biological sciences. Psychology Humans Insulin Resistance Kinetics Lipids - blood Lipoproteins, VLDL - blood Lipoproteins, VLDL - metabolism Male Medical sciences Middle Aged Obesity Physical Fitness Quality of Life Time Factors Vertebrates: endocrinology |
| title | The Effect of a Six-Month Exercise Program on Very Low-Density Lipoprotein Apolipoprotein B Secretion in Type 2 Diabetes |
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