Thyroid hormone and phenotypes of cardioprotection
Thyroid hormone has multiple effects on the cardiovascular system with important physiological consequences. Several genes that encode important regulatory and structural proteins in the heart have been shown to be thyroid hormone responsive. More notably, certain effects of thyroid hormone have bee...
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| Veröffentlicht in: | Basic research in cardiology 2004-03, Vol.99 (2), p.101-120 |
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| container_title | Basic research in cardiology |
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| creator | Pantos, Constantinos Malliopoulou, Vassiliki Varonos, Dennis D Cokkinos, Dennis V |
| description | Thyroid hormone has multiple effects on the cardiovascular system with important physiological consequences. Several genes that encode important regulatory and structural proteins in the heart have been shown to be thyroid hormone responsive. More notably, certain effects of thyroid hormone have been exploited therapeutically. Thyroid hormone is currently being evaluated as an inotrope and vasodilator in various clinical settings. Furthermore, new information has been recently accumulated on the role of thyroid hormone in the response of the heart to ischaemic stress. In fact, hyperthyroid and hypothyroid hearts display a phenotype of cardioprotection against ischaemia-reperfusion. Based on this evidence, the various actions of thyroid hormone on the cardiovascular system are highlighted in this review. Thyroid hormone, although limited by its adverse effects, might prove a suitable treatment for cardiovascular illnesses. Various thyroid hormone analogues are currently under development. |
| doi_str_mv | 10.1007/s00395-003-0449-0 |
| format | Article |
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Several genes that encode important regulatory and structural proteins in the heart have been shown to be thyroid hormone responsive. More notably, certain effects of thyroid hormone have been exploited therapeutically. Thyroid hormone is currently being evaluated as an inotrope and vasodilator in various clinical settings. Furthermore, new information has been recently accumulated on the role of thyroid hormone in the response of the heart to ischaemic stress. In fact, hyperthyroid and hypothyroid hearts display a phenotype of cardioprotection against ischaemia-reperfusion. Based on this evidence, the various actions of thyroid hormone on the cardiovascular system are highlighted in this review. Thyroid hormone, although limited by its adverse effects, might prove a suitable treatment for cardiovascular illnesses. Various thyroid hormone analogues are currently under development.</description><identifier>ISSN: 0300-8428</identifier><identifier>EISSN: 1435-1803</identifier><identifier>DOI: 10.1007/s00395-003-0449-0</identifier><identifier>PMID: 14963669</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Animals ; Cardiotonic Agents - metabolism ; Cardiotonic Agents - therapeutic use ; Cardiovascular Physiological Phenomena ; Humans ; Myocardial Ischemia - drug therapy ; Myocardial Ischemia - metabolism ; Myocardial Ischemia - prevention & control ; Myocardial Reperfusion Injury - prevention & control ; Phenotype ; Thyroid Hormones - metabolism ; Thyroid Hormones - therapeutic use</subject><ispartof>Basic research in cardiology, 2004-03, Vol.99 (2), p.101-120</ispartof><rights>Copyright Springer-Verlag 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-4b214c3c4baaee0094f32166835dc30648dc6e222feb3207171ed90057c5f1ed3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14963669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pantos, Constantinos</creatorcontrib><creatorcontrib>Malliopoulou, Vassiliki</creatorcontrib><creatorcontrib>Varonos, Dennis D</creatorcontrib><creatorcontrib>Cokkinos, Dennis V</creatorcontrib><title>Thyroid hormone and phenotypes of cardioprotection</title><title>Basic research in cardiology</title><addtitle>Basic Res Cardiol</addtitle><description>Thyroid hormone has multiple effects on the cardiovascular system with important physiological consequences. 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| fulltext | fulltext |
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| ispartof | Basic research in cardiology, 2004-03, Vol.99 (2), p.101-120 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Cardiotonic Agents - metabolism Cardiotonic Agents - therapeutic use Cardiovascular Physiological Phenomena Humans Myocardial Ischemia - drug therapy Myocardial Ischemia - metabolism Myocardial Ischemia - prevention & control Myocardial Reperfusion Injury - prevention & control Phenotype Thyroid Hormones - metabolism Thyroid Hormones - therapeutic use |
| title | Thyroid hormone and phenotypes of cardioprotection |
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