Region-selective stress-induced increase of glutamate uptake and release in rat forebrain
The study describes stress-induced changes in high-affinity uptake and release of glutamate by synaptosomal preparations from several regions of rat brain. The results demonstrate that restraint stress can lead to increased glutamate uptake and release in limbic forebrain regions (frontal cortex, hi...
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| Veröffentlicht in: | Brain research 1990-08, Vol.525 (2), p.335-338 |
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| container_end_page | 338 |
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| container_title | Brain research |
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| creator | Gilad, Gad M. Gilad, Varda H. Wyatt, Richard Jed Tizabi, Yousef |
| description | The study describes stress-induced changes in high-affinity uptake and release of glutamate by synaptosomal preparations from several regions of rat brain. The results demonstrate that restraint stress can lead to increased glutamate uptake and release in limbic forebrain regions (frontal cortex, hippocampus and septum) but not in the striatum. The increase in glutamate uptake was evident after 30 min of stress. A plateau (140–150% of unhandled controls) was reached after 1 h and was maintained after 4 h of continuous stress. The stress-induced increase in glutamate uptake was observed with glutamate concentrations of up to 10 μM, but not with 500 μM. The results indicate that forebrain glutamatergic terminals are activated by stressful stimuli in a regionally selective manner, and suggest that enhanced high-affinity uptake is important in clearing increased levels of released glutamate. |
| doi_str_mv | 10.1016/0006-8993(90)90886-G |
| format | Article |
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The results demonstrate that restraint stress can lead to increased glutamate uptake and release in limbic forebrain regions (frontal cortex, hippocampus and septum) but not in the striatum. The increase in glutamate uptake was evident after 30 min of stress. A plateau (140–150% of unhandled controls) was reached after 1 h and was maintained after 4 h of continuous stress. The stress-induced increase in glutamate uptake was observed with glutamate concentrations of up to 10 μM, but not with 500 μM. The results indicate that forebrain glutamatergic terminals are activated by stressful stimuli in a regionally selective manner, and suggest that enhanced high-affinity uptake is important in clearing increased levels of released glutamate.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(90)90886-G</identifier><identifier>PMID: 1979236</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Biological Transport ; Brain ; Brain - metabolism ; Glutamate release ; Glutamate uptake ; Glutamates - metabolism ; Glutamic Acid ; Handling (Psychology) ; Hippocampus - metabolism ; Kinetics ; Male ; Organ Specificity ; Rat ; Rats ; Rats, Inbred Strains ; Reference Values ; Restraint, Physical ; Space life sciences ; Stress ; Stress, Psychological - metabolism ; Synaptosomes - metabolism ; Tritium</subject><ispartof>Brain research, 1990-08, Vol.525 (2), p.335-338</ispartof><rights>1990 Elsevier Science Publishers B.V. 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The results demonstrate that restraint stress can lead to increased glutamate uptake and release in limbic forebrain regions (frontal cortex, hippocampus and septum) but not in the striatum. The increase in glutamate uptake was evident after 30 min of stress. A plateau (140–150% of unhandled controls) was reached after 1 h and was maintained after 4 h of continuous stress. The stress-induced increase in glutamate uptake was observed with glutamate concentrations of up to 10 μM, but not with 500 μM. The results indicate that forebrain glutamatergic terminals are activated by stressful stimuli in a regionally selective manner, and suggest that enhanced high-affinity uptake is important in clearing increased levels of released glutamate.</description><subject>Animals</subject><subject>Biological Transport</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Glutamate release</subject><subject>Glutamate uptake</subject><subject>Glutamates - metabolism</subject><subject>Glutamic Acid</subject><subject>Handling (Psychology)</subject><subject>Hippocampus - metabolism</subject><subject>Kinetics</subject><subject>Male</subject><subject>Organ Specificity</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reference Values</subject><subject>Restraint, Physical</subject><subject>Space life sciences</subject><subject>Stress</subject><subject>Stress, Psychological - metabolism</subject><subject>Synaptosomes - metabolism</subject><subject>Tritium</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LJDEQhoO46Oj6DxRyEj30WkkmXxdBZHcUhIVFD3sK6aRaoj3dY9It-O_tcURveiqK93mr4CHkkMEvBkydAYCqjLXixMKpBWNUtdgiM2Y0rxSfwzaZfSC7ZK-Uh2kVwsIO2WFWWy7UjPz_h_ep76qCLYYhPSMtQ8ZSqtTFMWCkqQsZfUHaN_S-HQe_9APScTX4R6S-izRPzXWeOpr9QJs-Y5196n6SH41vCx68z31y9-f37eVVdfN3cX15cVMFCXKoalbXQjMmg0IldNMEa4QAA1FGIaWQOPeotYgKpNRSGd2AkCFyHqMxOoh9cry5u8r904hlcMtUArat77AfizPAJLecfwsyaUDMuZzA-QYMuS8lY-NWOS19fnEM3Fq9W3t1a6_OgntT7xZT7ej9_lgvMX6WNq6n_HyT42TjOWF2JSTsJskpT-5d7NPXD14B33eSvA</recordid><startdate>19900820</startdate><enddate>19900820</enddate><creator>Gilad, Gad M.</creator><creator>Gilad, Varda H.</creator><creator>Wyatt, Richard Jed</creator><creator>Tizabi, Yousef</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19900820</creationdate><title>Region-selective stress-induced increase of glutamate uptake and release in rat forebrain</title><author>Gilad, Gad M. ; Gilad, Varda H. ; Wyatt, Richard Jed ; Tizabi, Yousef</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-b1bb37115c6e637ffc9833080d5d35535e4ae773d605575687f035cd22dd887c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological Transport</topic><topic>Brain</topic><topic>Brain - metabolism</topic><topic>Glutamate release</topic><topic>Glutamate uptake</topic><topic>Glutamates - metabolism</topic><topic>Glutamic Acid</topic><topic>Handling (Psychology)</topic><topic>Hippocampus - metabolism</topic><topic>Kinetics</topic><topic>Male</topic><topic>Organ Specificity</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reference Values</topic><topic>Restraint, Physical</topic><topic>Space life sciences</topic><topic>Stress</topic><topic>Stress, Psychological - metabolism</topic><topic>Synaptosomes - metabolism</topic><topic>Tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gilad, Gad M.</creatorcontrib><creatorcontrib>Gilad, Varda H.</creatorcontrib><creatorcontrib>Wyatt, Richard Jed</creatorcontrib><creatorcontrib>Tizabi, Yousef</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gilad, Gad M.</au><au>Gilad, Varda H.</au><au>Wyatt, Richard Jed</au><au>Tizabi, Yousef</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Region-selective stress-induced increase of glutamate uptake and release in rat forebrain</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1990-08-20</date><risdate>1990</risdate><volume>525</volume><issue>2</issue><spage>335</spage><epage>338</epage><pages>335-338</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>The study describes stress-induced changes in high-affinity uptake and release of glutamate by synaptosomal preparations from several regions of rat brain. The results demonstrate that restraint stress can lead to increased glutamate uptake and release in limbic forebrain regions (frontal cortex, hippocampus and septum) but not in the striatum. The increase in glutamate uptake was evident after 30 min of stress. A plateau (140–150% of unhandled controls) was reached after 1 h and was maintained after 4 h of continuous stress. The stress-induced increase in glutamate uptake was observed with glutamate concentrations of up to 10 μM, but not with 500 μM. The results indicate that forebrain glutamatergic terminals are activated by stressful stimuli in a regionally selective manner, and suggest that enhanced high-affinity uptake is important in clearing increased levels of released glutamate.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>1979236</pmid><doi>10.1016/0006-8993(90)90886-G</doi><tpages>4</tpages></addata></record> |
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| ispartof | Brain research, 1990-08, Vol.525 (2), p.335-338 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological Transport Brain Brain - metabolism Glutamate release Glutamate uptake Glutamates - metabolism Glutamic Acid Handling (Psychology) Hippocampus - metabolism Kinetics Male Organ Specificity Rat Rats Rats, Inbred Strains Reference Values Restraint, Physical Space life sciences Stress Stress, Psychological - metabolism Synaptosomes - metabolism Tritium |
| title | Region-selective stress-induced increase of glutamate uptake and release in rat forebrain |
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