The effect of replacement fluids and normovolaemic haemodilution on the survival of dorsal skin flaps in rats
The effect of replacement fluids and normovolaemic haemodilution on the survival of dorsal skin flaps in rats The objective of this study is to investigate the effect of normovolaemic haemodilution (anaemia), haemoglobin level and replacement fluids on the survival of local flaps in rats. Fifty male...
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| Veröffentlicht in: | Clinical otolaryngology and allied sciences 2004-02, Vol.29 (1), p.80-83 |
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| creator | Tüz, M. Eroğlu, E. Doğru, H. Deli̇baş, N. Tunç, B. Uygur, K. |
| description | The effect of replacement fluids and normovolaemic haemodilution on the survival of dorsal skin flaps in rats The objective of this study is to investigate the effect of normovolaemic haemodilution (anaemia), haemoglobin level and replacement fluids on the survival of local flaps in rats. Fifty male Wistar rats were divided into four study groups and one control group (10 rats for each). In the study groups, 20% or 30% of blood was withdrawn and replaced by either Gelofusine® or saline (0.9%). Single 1.5 cm × 3 cm cranially based dorsal random skin flaps consisting of skin and panniculus carnosus were elevated in all rats. No difference was determined between the control and 20% exsanguinated groups regarding flap survival area. There was a statistically significant difference between the flap survival areas of 20% exsanguinated groups and 30% exsanguinated groups. If the blood loss exceeds 30% of total volume and/or haemoglobin (Hb) level is lower than 10.72 g/dL, the risk of flap necrosis increases significantly. |
| doi_str_mv | 10.1111/j.1365-2273.2004.00787.x |
| format | Article |
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Fifty male Wistar rats were divided into four study groups and one control group (10 rats for each). In the study groups, 20% or 30% of blood was withdrawn and replaced by either Gelofusine® or saline (0.9%). Single 1.5 cm × 3 cm cranially based dorsal random skin flaps consisting of skin and panniculus carnosus were elevated in all rats. No difference was determined between the control and 20% exsanguinated groups regarding flap survival area. There was a statistically significant difference between the flap survival areas of 20% exsanguinated groups and 30% exsanguinated groups. If the blood loss exceeds 30% of total volume and/or haemoglobin (Hb) level is lower than 10.72 g/dL, the risk of flap necrosis increases significantly.</description><identifier>ISSN: 0307-7772</identifier><identifier>EISSN: 1365-2273</identifier><identifier>DOI: 10.1111/j.1365-2273.2004.00787.x</identifier><identifier>PMID: 14961857</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Anemia - blood ; Anemia - complications ; Animals ; flap ; Fluid Therapy ; Gelatin - administration & dosage ; Graft Survival - drug effects ; haemoglobin ; Hemodilution - methods ; Hemoglobins - analysis ; Hypovolemia - complications ; Male ; normovolaemic haemodilution ; Plasma Substitutes - administration & dosage ; rat ; Rats ; Rats, Wistar ; Sodium Chloride - administration & dosage ; Succinates - administration & dosage ; Surgical Flaps - blood supply</subject><ispartof>Clinical otolaryngology and allied sciences, 2004-02, Vol.29 (1), p.80-83</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4707-c318f6f3f542a6f3ed0831bce92039ede430f4f23db472d9604e51c1307a24973</citedby><cites>FETCH-LOGICAL-c4707-c318f6f3f542a6f3ed0831bce92039ede430f4f23db472d9604e51c1307a24973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2273.2004.00787.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2273.2004.00787.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14961857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tüz, M.</creatorcontrib><creatorcontrib>Eroğlu, E.</creatorcontrib><creatorcontrib>Doğru, H.</creatorcontrib><creatorcontrib>Deli̇baş, N.</creatorcontrib><creatorcontrib>Tunç, B.</creatorcontrib><creatorcontrib>Uygur, K.</creatorcontrib><title>The effect of replacement fluids and normovolaemic haemodilution on the survival of dorsal skin flaps in rats</title><title>Clinical otolaryngology and allied sciences</title><addtitle>Clin Otolaryngol Allied Sci</addtitle><description>The effect of replacement fluids and normovolaemic haemodilution on the survival of dorsal skin flaps in rats The objective of this study is to investigate the effect of normovolaemic haemodilution (anaemia), haemoglobin level and replacement fluids on the survival of local flaps in rats. Fifty male Wistar rats were divided into four study groups and one control group (10 rats for each). In the study groups, 20% or 30% of blood was withdrawn and replaced by either Gelofusine® or saline (0.9%). Single 1.5 cm × 3 cm cranially based dorsal random skin flaps consisting of skin and panniculus carnosus were elevated in all rats. No difference was determined between the control and 20% exsanguinated groups regarding flap survival area. There was a statistically significant difference between the flap survival areas of 20% exsanguinated groups and 30% exsanguinated groups. If the blood loss exceeds 30% of total volume and/or haemoglobin (Hb) level is lower than 10.72 g/dL, the risk of flap necrosis increases significantly.</description><subject>Anemia - blood</subject><subject>Anemia - complications</subject><subject>Animals</subject><subject>flap</subject><subject>Fluid Therapy</subject><subject>Gelatin - administration & dosage</subject><subject>Graft Survival - drug effects</subject><subject>haemoglobin</subject><subject>Hemodilution - methods</subject><subject>Hemoglobins - analysis</subject><subject>Hypovolemia - complications</subject><subject>Male</subject><subject>normovolaemic haemodilution</subject><subject>Plasma Substitutes - administration & dosage</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sodium Chloride - administration & dosage</subject><subject>Succinates - administration & dosage</subject><subject>Surgical Flaps - blood supply</subject><issn>0307-7772</issn><issn>1365-2273</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1u1DAUhS0EotPCKyCv2CX4L3EisakGaKmqVq0KXVoe51r11IkHOxmmb1-HGbVbLEv3SD7n2P4QwpSUNK8v65LyuioYk7xkhIiSENnIcvcGLV4O3qIF4UQWUkp2hI5TWpPspFK-R0dUtDVtKrlA_d0DYLAWzIiDxRE2XhvoYRix9ZPrEtZDh4cQ-7ANXkPvDH7II3TOT6MLA857zB1pilu31X5u6UJMWaVHN-QWvUk4i6jH9AG9s9on-HiYJ-jXj-93y_Pi8vrs5_L0sjBC5icbThtbW24rwXSe0JGG05WBlhHeQgeCEyss491KSNa1NRFQUUPzdzUTreQn6PO-dxPDnwnSqHqXDHivBwhTUg2hFWsEycZmbzQxpBTBqk10vY5PihI1o1ZrNRNVM1E1o1b_UKtdjn463DGteuhegwe22fB1b_jrPDz9d7FaXp9mkePFPu7SCLuXuI6PqpZcVur-6kzd3l98O7_5XakL_gxwDZz4</recordid><startdate>200402</startdate><enddate>200402</enddate><creator>Tüz, M.</creator><creator>Eroğlu, E.</creator><creator>Doğru, H.</creator><creator>Deli̇baş, N.</creator><creator>Tunç, B.</creator><creator>Uygur, K.</creator><general>Blackwell Science Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200402</creationdate><title>The effect of replacement fluids and normovolaemic haemodilution on the survival of dorsal skin flaps in rats</title><author>Tüz, M. ; Eroğlu, E. ; Doğru, H. ; Deli̇baş, N. ; Tunç, B. ; Uygur, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4707-c318f6f3f542a6f3ed0831bce92039ede430f4f23db472d9604e51c1307a24973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Anemia - blood</topic><topic>Anemia - complications</topic><topic>Animals</topic><topic>flap</topic><topic>Fluid Therapy</topic><topic>Gelatin - administration & dosage</topic><topic>Graft Survival - drug effects</topic><topic>haemoglobin</topic><topic>Hemodilution - methods</topic><topic>Hemoglobins - analysis</topic><topic>Hypovolemia - complications</topic><topic>Male</topic><topic>normovolaemic haemodilution</topic><topic>Plasma Substitutes - administration & dosage</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sodium Chloride - administration & dosage</topic><topic>Succinates - administration & dosage</topic><topic>Surgical Flaps - blood supply</topic><toplevel>online_resources</toplevel><creatorcontrib>Tüz, M.</creatorcontrib><creatorcontrib>Eroğlu, E.</creatorcontrib><creatorcontrib>Doğru, H.</creatorcontrib><creatorcontrib>Deli̇baş, N.</creatorcontrib><creatorcontrib>Tunç, B.</creatorcontrib><creatorcontrib>Uygur, K.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical otolaryngology and allied sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tüz, M.</au><au>Eroğlu, E.</au><au>Doğru, H.</au><au>Deli̇baş, N.</au><au>Tunç, B.</au><au>Uygur, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of replacement fluids and normovolaemic haemodilution on the survival of dorsal skin flaps in rats</atitle><jtitle>Clinical otolaryngology and allied sciences</jtitle><addtitle>Clin Otolaryngol Allied Sci</addtitle><date>2004-02</date><risdate>2004</risdate><volume>29</volume><issue>1</issue><spage>80</spage><epage>83</epage><pages>80-83</pages><issn>0307-7772</issn><eissn>1365-2273</eissn><abstract>The effect of replacement fluids and normovolaemic haemodilution on the survival of dorsal skin flaps in rats The objective of this study is to investigate the effect of normovolaemic haemodilution (anaemia), haemoglobin level and replacement fluids on the survival of local flaps in rats. 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| ispartof | Clinical otolaryngology and allied sciences, 2004-02, Vol.29 (1), p.80-83 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Anemia - blood Anemia - complications Animals flap Fluid Therapy Gelatin - administration & dosage Graft Survival - drug effects haemoglobin Hemodilution - methods Hemoglobins - analysis Hypovolemia - complications Male normovolaemic haemodilution Plasma Substitutes - administration & dosage rat Rats Rats, Wistar Sodium Chloride - administration & dosage Succinates - administration & dosage Surgical Flaps - blood supply |
| title | The effect of replacement fluids and normovolaemic haemodilution on the survival of dorsal skin flaps in rats |
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