Pinealectomy induces malformation of the spine and reduces the mechanical strength of the vertebrae in Atlantic salmon, Salmo salar
: This study describes the long‐term effects of surgical ablation of the pineal gland on the spine of 3‐yr‐old Atlantic salmon (Salmo salar L.) with a mean weight of 3.2 kg. Radiographic examinations showed that 82% of the pinealectomized fish developed marked lateral (scoliosis) and dorso‐ventral...
Gespeichert in:
| Veröffentlicht in: | Journal of pineal research 2004-03, Vol.36 (2), p.132-139 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 139 |
|---|---|
| container_issue | 2 |
| container_start_page | 132 |
| container_title | Journal of pineal research |
| container_volume | 36 |
| creator | Fjelldal, Per Gunnar Grotmol, Sindre Kryvi, Harald Gjerdet, Nils Roar Taranger, Geir Lasse Hansen, Tom Porter, Mark J. R. Totland, Geir K. |
| description | : This study describes the long‐term effects of surgical ablation of the pineal gland on the spine of 3‐yr‐old Atlantic salmon (Salmo salar L.) with a mean weight of 3.2 kg. Radiographic examinations showed that 82% of the pinealectomized fish developed marked lateral (scoliosis) and dorso‐ventral spinal curvatures. The proportions of the individual vertebral bodies and their mechanical properties were also altered. The stiffness, yield limit and resilience of the vertebral bodies, as measured by compression in the cranio‐caudal direction, were significantly lower in the pinealectomized than in the sham‐pinealectomized group. Calcium, phosphorous and total mineral content of the vertebral bodies were also significantly lower in the pinealectomized fish, while these parameters were similar in scales in the two groups. Alterations of the spinal curve accompanied by changes in the proportions, mechanical strength and mineral content of the vertebral bodies of the pinealectomized salmon indicate that melatonin has several functions related to vertebral bone growth. As the lesions found in salmon are similar to the spinal malformations observed in avian species and mammals after pinealectomy, this study strengthens the hypothesis of a phylogenetically conserved function of the pineal gland related to skeletal development. |
| doi_str_mv | 10.1046/j.1600-079X.2003.00109.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80152673</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20674457</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5849-66b38ad87ee4e6568526e11d1b37489df4d1cfadcaf5e849b6c6997cc1f966113</originalsourceid><addsrcrecordid>eNqNkUtv1DAURi0EokPhLyBvYEWCnTiOLbGpqlI6rUoRz53lONeMhzwG2wMza_44DhnaJaz8Ouf66n4IYUpyShh_uc4pJyQjtfySF4SUOSGUyHx3Dy1uH-6jBalZkZVEiiP0KIQ1IUQIwR-iI8okLwivFujXjRtAd2Di2O-xG9qtgYB73dnR9zq6ccCjxXEFOGwSifXQYg8zNd32YFZ6cEZ3OEQPw9e4-iv8AB-h8RpSWXwSOz1EZ3DQXT8OL_D7aZ1O2j9GD6zuAjw5rMfo4-uzD6dvsqu35xenJ1eZqQSTGedNKXQragAGvOKiKjhQ2tKmrJmQrWUtNVa3RtsKktBww6WsjaFWck5peYyez3U3fvy-hRBV74KBLnUG4zYoQWgqWZf_BNPoasaqOoFiBo0fQ_Bg1ca7Xvu9okRNSam1mgJRUyBqSkr9SUrtkvr08Me26aG9Ew_RJODZAdAhjdd6PRgX7riqKgoqJu7VzP10Hez_uwG1vLlIm6Rns-5ChN2trv03lUZRV-rz9bm6XL4rlp-W1-qy_A3rOMAl</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20674457</pqid></control><display><type>article</type><title>Pinealectomy induces malformation of the spine and reduces the mechanical strength of the vertebrae in Atlantic salmon, Salmo salar</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Fjelldal, Per Gunnar ; Grotmol, Sindre ; Kryvi, Harald ; Gjerdet, Nils Roar ; Taranger, Geir Lasse ; Hansen, Tom ; Porter, Mark J. R. ; Totland, Geir K.</creator><creatorcontrib>Fjelldal, Per Gunnar ; Grotmol, Sindre ; Kryvi, Harald ; Gjerdet, Nils Roar ; Taranger, Geir Lasse ; Hansen, Tom ; Porter, Mark J. R. ; Totland, Geir K.</creatorcontrib><description>: This study describes the long‐term effects of surgical ablation of the pineal gland on the spine of 3‐yr‐old Atlantic salmon (Salmo salar L.) with a mean weight of 3.2 kg. Radiographic examinations showed that 82% of the pinealectomized fish developed marked lateral (scoliosis) and dorso‐ventral spinal curvatures. The proportions of the individual vertebral bodies and their mechanical properties were also altered. The stiffness, yield limit and resilience of the vertebral bodies, as measured by compression in the cranio‐caudal direction, were significantly lower in the pinealectomized than in the sham‐pinealectomized group. Calcium, phosphorous and total mineral content of the vertebral bodies were also significantly lower in the pinealectomized fish, while these parameters were similar in scales in the two groups. Alterations of the spinal curve accompanied by changes in the proportions, mechanical strength and mineral content of the vertebral bodies of the pinealectomized salmon indicate that melatonin has several functions related to vertebral bone growth. As the lesions found in salmon are similar to the spinal malformations observed in avian species and mammals after pinealectomy, this study strengthens the hypothesis of a phylogenetically conserved function of the pineal gland related to skeletal development.</description><identifier>ISSN: 0742-3098</identifier><identifier>EISSN: 1600-079X</identifier><identifier>DOI: 10.1046/j.1600-079X.2003.00109.x</identifier><identifier>PMID: 14962065</identifier><identifier>CODEN: JPRSE9</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Animals ; Atlantic salmon ; Biological and medical sciences ; Body Constitution - physiology ; Calcium - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Male ; malformation ; Marine ; mechanical properties ; melatonin ; Phosphorus - metabolism ; Pineal Gland - surgery ; pinealectomy ; Salmo salar ; Salmo salar - growth & development ; Salmo salar - metabolism ; spine ; Spine - abnormalities ; Tensile Strength ; vertebra ; Vertebrates: endocrinology</subject><ispartof>Journal of pineal research, 2004-03, Vol.36 (2), p.132-139</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5849-66b38ad87ee4e6568526e11d1b37489df4d1cfadcaf5e849b6c6997cc1f966113</citedby><cites>FETCH-LOGICAL-c5849-66b38ad87ee4e6568526e11d1b37489df4d1cfadcaf5e849b6c6997cc1f966113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1600-079X.2003.00109.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1600-079X.2003.00109.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15522185$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14962065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fjelldal, Per Gunnar</creatorcontrib><creatorcontrib>Grotmol, Sindre</creatorcontrib><creatorcontrib>Kryvi, Harald</creatorcontrib><creatorcontrib>Gjerdet, Nils Roar</creatorcontrib><creatorcontrib>Taranger, Geir Lasse</creatorcontrib><creatorcontrib>Hansen, Tom</creatorcontrib><creatorcontrib>Porter, Mark J. R.</creatorcontrib><creatorcontrib>Totland, Geir K.</creatorcontrib><title>Pinealectomy induces malformation of the spine and reduces the mechanical strength of the vertebrae in Atlantic salmon, Salmo salar</title><title>Journal of pineal research</title><addtitle>J Pineal Res</addtitle><description>: This study describes the long‐term effects of surgical ablation of the pineal gland on the spine of 3‐yr‐old Atlantic salmon (Salmo salar L.) with a mean weight of 3.2 kg. Radiographic examinations showed that 82% of the pinealectomized fish developed marked lateral (scoliosis) and dorso‐ventral spinal curvatures. The proportions of the individual vertebral bodies and their mechanical properties were also altered. The stiffness, yield limit and resilience of the vertebral bodies, as measured by compression in the cranio‐caudal direction, were significantly lower in the pinealectomized than in the sham‐pinealectomized group. Calcium, phosphorous and total mineral content of the vertebral bodies were also significantly lower in the pinealectomized fish, while these parameters were similar in scales in the two groups. Alterations of the spinal curve accompanied by changes in the proportions, mechanical strength and mineral content of the vertebral bodies of the pinealectomized salmon indicate that melatonin has several functions related to vertebral bone growth. As the lesions found in salmon are similar to the spinal malformations observed in avian species and mammals after pinealectomy, this study strengthens the hypothesis of a phylogenetically conserved function of the pineal gland related to skeletal development.</description><subject>Animals</subject><subject>Atlantic salmon</subject><subject>Biological and medical sciences</subject><subject>Body Constitution - physiology</subject><subject>Calcium - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>malformation</subject><subject>Marine</subject><subject>mechanical properties</subject><subject>melatonin</subject><subject>Phosphorus - metabolism</subject><subject>Pineal Gland - surgery</subject><subject>pinealectomy</subject><subject>Salmo salar</subject><subject>Salmo salar - growth & development</subject><subject>Salmo salar - metabolism</subject><subject>spine</subject><subject>Spine - abnormalities</subject><subject>Tensile Strength</subject><subject>vertebra</subject><subject>Vertebrates: endocrinology</subject><issn>0742-3098</issn><issn>1600-079X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAURi0EokPhLyBvYEWCnTiOLbGpqlI6rUoRz53lONeMhzwG2wMza_44DhnaJaz8Ouf66n4IYUpyShh_uc4pJyQjtfySF4SUOSGUyHx3Dy1uH-6jBalZkZVEiiP0KIQ1IUQIwR-iI8okLwivFujXjRtAd2Di2O-xG9qtgYB73dnR9zq6ccCjxXEFOGwSifXQYg8zNd32YFZ6cEZ3OEQPw9e4-iv8AB-h8RpSWXwSOz1EZ3DQXT8OL_D7aZ1O2j9GD6zuAjw5rMfo4-uzD6dvsqu35xenJ1eZqQSTGedNKXQragAGvOKiKjhQ2tKmrJmQrWUtNVa3RtsKktBww6WsjaFWck5peYyez3U3fvy-hRBV74KBLnUG4zYoQWgqWZf_BNPoasaqOoFiBo0fQ_Bg1ca7Xvu9okRNSam1mgJRUyBqSkr9SUrtkvr08Me26aG9Ew_RJODZAdAhjdd6PRgX7riqKgoqJu7VzP10Hez_uwG1vLlIm6Rns-5ChN2trv03lUZRV-rz9bm6XL4rlp-W1-qy_A3rOMAl</recordid><startdate>200403</startdate><enddate>200403</enddate><creator>Fjelldal, Per Gunnar</creator><creator>Grotmol, Sindre</creator><creator>Kryvi, Harald</creator><creator>Gjerdet, Nils Roar</creator><creator>Taranger, Geir Lasse</creator><creator>Hansen, Tom</creator><creator>Porter, Mark J. R.</creator><creator>Totland, Geir K.</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>200403</creationdate><title>Pinealectomy induces malformation of the spine and reduces the mechanical strength of the vertebrae in Atlantic salmon, Salmo salar</title><author>Fjelldal, Per Gunnar ; Grotmol, Sindre ; Kryvi, Harald ; Gjerdet, Nils Roar ; Taranger, Geir Lasse ; Hansen, Tom ; Porter, Mark J. R. ; Totland, Geir K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5849-66b38ad87ee4e6568526e11d1b37489df4d1cfadcaf5e849b6c6997cc1f966113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Atlantic salmon</topic><topic>Biological and medical sciences</topic><topic>Body Constitution - physiology</topic><topic>Calcium - metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>malformation</topic><topic>Marine</topic><topic>mechanical properties</topic><topic>melatonin</topic><topic>Phosphorus - metabolism</topic><topic>Pineal Gland - surgery</topic><topic>pinealectomy</topic><topic>Salmo salar</topic><topic>Salmo salar - growth & development</topic><topic>Salmo salar - metabolism</topic><topic>spine</topic><topic>Spine - abnormalities</topic><topic>Tensile Strength</topic><topic>vertebra</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fjelldal, Per Gunnar</creatorcontrib><creatorcontrib>Grotmol, Sindre</creatorcontrib><creatorcontrib>Kryvi, Harald</creatorcontrib><creatorcontrib>Gjerdet, Nils Roar</creatorcontrib><creatorcontrib>Taranger, Geir Lasse</creatorcontrib><creatorcontrib>Hansen, Tom</creatorcontrib><creatorcontrib>Porter, Mark J. R.</creatorcontrib><creatorcontrib>Totland, Geir K.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pineal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fjelldal, Per Gunnar</au><au>Grotmol, Sindre</au><au>Kryvi, Harald</au><au>Gjerdet, Nils Roar</au><au>Taranger, Geir Lasse</au><au>Hansen, Tom</au><au>Porter, Mark J. R.</au><au>Totland, Geir K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pinealectomy induces malformation of the spine and reduces the mechanical strength of the vertebrae in Atlantic salmon, Salmo salar</atitle><jtitle>Journal of pineal research</jtitle><addtitle>J Pineal Res</addtitle><date>2004-03</date><risdate>2004</risdate><volume>36</volume><issue>2</issue><spage>132</spage><epage>139</epage><pages>132-139</pages><issn>0742-3098</issn><eissn>1600-079X</eissn><coden>JPRSE9</coden><abstract>: This study describes the long‐term effects of surgical ablation of the pineal gland on the spine of 3‐yr‐old Atlantic salmon (Salmo salar L.) with a mean weight of 3.2 kg. Radiographic examinations showed that 82% of the pinealectomized fish developed marked lateral (scoliosis) and dorso‐ventral spinal curvatures. The proportions of the individual vertebral bodies and their mechanical properties were also altered. The stiffness, yield limit and resilience of the vertebral bodies, as measured by compression in the cranio‐caudal direction, were significantly lower in the pinealectomized than in the sham‐pinealectomized group. Calcium, phosphorous and total mineral content of the vertebral bodies were also significantly lower in the pinealectomized fish, while these parameters were similar in scales in the two groups. Alterations of the spinal curve accompanied by changes in the proportions, mechanical strength and mineral content of the vertebral bodies of the pinealectomized salmon indicate that melatonin has several functions related to vertebral bone growth. As the lesions found in salmon are similar to the spinal malformations observed in avian species and mammals after pinealectomy, this study strengthens the hypothesis of a phylogenetically conserved function of the pineal gland related to skeletal development.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>14962065</pmid><doi>10.1046/j.1600-079X.2003.00109.x</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0742-3098 |
| ispartof | Journal of pineal research, 2004-03, Vol.36 (2), p.132-139 |
| issn | 0742-3098 1600-079X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80152673 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Atlantic salmon Biological and medical sciences Body Constitution - physiology Calcium - metabolism Female Fundamental and applied biological sciences. Psychology Male malformation Marine mechanical properties melatonin Phosphorus - metabolism Pineal Gland - surgery pinealectomy Salmo salar Salmo salar - growth & development Salmo salar - metabolism spine Spine - abnormalities Tensile Strength vertebra Vertebrates: endocrinology |
| title | Pinealectomy induces malformation of the spine and reduces the mechanical strength of the vertebrae in Atlantic salmon, Salmo salar |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T15%3A55%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pinealectomy%20induces%20malformation%20of%20the%20spine%20and%20reduces%20the%20mechanical%20strength%20of%20the%20vertebrae%20in%20Atlantic%20salmon,%20Salmo%20salar&rft.jtitle=Journal%20of%20pineal%20research&rft.au=Fjelldal,%20Per%20Gunnar&rft.date=2004-03&rft.volume=36&rft.issue=2&rft.spage=132&rft.epage=139&rft.pages=132-139&rft.issn=0742-3098&rft.eissn=1600-079X&rft.coden=JPRSE9&rft_id=info:doi/10.1046/j.1600-079X.2003.00109.x&rft_dat=%3Cproquest_cross%3E20674457%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20674457&rft_id=info:pmid/14962065&rfr_iscdi=true |