An E. coli Ribonucleoprotein Containing 4.5S RNA Resembles Mammalian Signal Recognition Particle

The signal recognition particle (SRP) plays a central role in directing the export of nascent proteins from the cytoplasm of mammalian cells. An SRP-dependent translocation machinery in bacteria has not been demonstrated in previous genetic and biochemical studies. Sequence comparisons, however, hav...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1990-11, Vol.250 (4984), p.1111-1117
Hauptverfasser:	Poritz, Mark A., Bernstein, Harris D., Strub, Katharina, Zopf, Dieter, Wilhelm, Heike, Walter, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Antibodies Bacteria Bacterial Proteins - metabolism Base Sequence Biological and medical sciences Biological transport Blood Cell growth Cell physiology Cellular biology Cellular signal transduction Chaperonins Enzyme Activation Escherichia coli - genetics Fundamental and applied biological sciences. Psychology Genes, Bacterial GTP Phosphohydrolases - metabolism Heat-Shock Proteins - biosynthesis Hot Temperature Immunosorbent Techniques Inductive reasoning Isopropyl Thiogalactoside - pharmacology Mammals Membrane and intracellular transports Molecular and cellular biology Molecular Sequence Data Mutation Nucleoproteins Protein Sorting Signals - metabolism Protein transport Proteins Receptors Recombinant Fusion Proteins - metabolism Ribonucleoproteins - genetics Ribonucleoproteins - metabolism Ribosomes RNA RNA, Bacterial - genetics RNA, Bacterial - metabolism Sequence Homology, Nucleic Acid Shock heating Signal Recognition Particle
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