Ion−Molecule Reactions for Mass Spectrometric Identification of Functional Groups in Protonated Oxygen-Containing Monofunctional Compounds
Protonated oxygen-containing monofunctional compounds react with selected methoxyborane reagents by proton transfer followed by nucleophilic substitution of methanol at the boron atom in a Fourier transform ion cyclotron resonance mass spectrometer. The derivatized oxygen functionality can be identi...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2004-02, Vol.76 (4), p.964-976 |
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| container_title | Analytical chemistry (Washington) |
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| creator | Watkins, Michael A Price, Jason M Winger, Brian E Kenttämaa, Hilkka I |
| description | Protonated oxygen-containing monofunctional compounds react with selected methoxyborane reagents by proton transfer followed by nucleophilic substitution of methanol at the boron atom in a Fourier transform ion cyclotron resonance mass spectrometer. The derivatized oxygen functionality can be identified by H/D exchange, collision-activated dissociation, or both. This information on the identity of the functionalities in the analyte, in conjunction with molecular formula information obtained from exact mass measurements on either the protonated or derivatized analyte, facilitates structure elucidation of unknown organic compounds in a mass spectrometer. |
| doi_str_mv | 10.1021/ac034946d |
| format | Article |
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The derivatized oxygen functionality can be identified by H/D exchange, collision-activated dissociation, or both. 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This information on the identity of the functionalities in the analyte, in conjunction with molecular formula information obtained from exact mass measurements on either the protonated or derivatized analyte, facilitates structure elucidation of unknown organic compounds in a mass spectrometer.</description><subject>Analytical chemistry</subject><subject>Chemical compounds</subject><subject>Chemistry</subject><subject>Exact sciences and technology</subject><subject>Ions</subject><subject>Molecules</subject><subject>Oxygen</subject><subject>Scientific imaging</subject><subject>Spectrometric and optical methods</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNpl0UFrFDEUB_Agil2rB7-ABEHBw-hLZpLMHGVx14WurbaCeAlpJimpM8mYZKD9Bh48-RH9JM66Swf0FEh-7_Fe_gg9JfCaACVvlIayaire3kMLwigUvK7pfbQAgLKgAuAIPUrpGoAQIPwhOiJVw4mgYoF-boL__ePXNnRGj53Bn4zS2QWfsA0Rb1VK-HwwOsfQmxydxpvW-Oys02rHcLB4Nfq_JarD6xjGIWHn8VkMebrKpsWnN7dXxhfL4LNy3vkrvA0-2LlqGfohjL5Nj9EDq7pknhzOY_R59e5i-b44OV1vlm9PClUBz4WxtGmZ4MJUjCmquCa2VU1dCy2amjaEcmYaW3EG9FLX0EBpqQZtWs6sBlseo5f7vkMM30eTsuxd0qbrlDdhTLKG3S8KPsHn_8DrMMZp5iQpETXnjJMJvdojHUNK0Vg5RNereCsJyF0-8i6fyT47NBwve9PO8hDIBF4cgEpadTYqr12aHWNTirScXLF3LmVzc_eu4jfJRSmYvDg7l4J9_UhW6y_yw9xX6TQv8f-AfwCU77XQ</recordid><startdate>20040215</startdate><enddate>20040215</enddate><creator>Watkins, Michael A</creator><creator>Price, Jason M</creator><creator>Winger, Brian E</creator><creator>Kenttämaa, Hilkka I</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20040215</creationdate><title>Ion−Molecule Reactions for Mass Spectrometric Identification of Functional Groups in Protonated Oxygen-Containing Monofunctional Compounds</title><author>Watkins, Michael A ; Price, Jason M ; Winger, Brian E ; Kenttämaa, Hilkka I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a406t-ef29d5767e455a2a6c1fda9887c798291265e9f46502bc80903f2c0ced65fc0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Analytical chemistry</topic><topic>Chemical compounds</topic><topic>Chemistry</topic><topic>Exact sciences and technology</topic><topic>Ions</topic><topic>Molecules</topic><topic>Oxygen</topic><topic>Scientific imaging</topic><topic>Spectrometric and optical methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Watkins, Michael A</creatorcontrib><creatorcontrib>Price, Jason M</creatorcontrib><creatorcontrib>Winger, Brian E</creatorcontrib><creatorcontrib>Kenttämaa, Hilkka I</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Watkins, Michael A</au><au>Price, Jason M</au><au>Winger, Brian E</au><au>Kenttämaa, Hilkka I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ion−Molecule Reactions for Mass Spectrometric Identification of Functional Groups in Protonated Oxygen-Containing Monofunctional Compounds</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2004-02-15</date><risdate>2004</risdate><volume>76</volume><issue>4</issue><spage>964</spage><epage>976</epage><pages>964-976</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>Protonated oxygen-containing monofunctional compounds react with selected methoxyborane reagents by proton transfer followed by nucleophilic substitution of methanol at the boron atom in a Fourier transform ion cyclotron resonance mass spectrometer. The derivatized oxygen functionality can be identified by H/D exchange, collision-activated dissociation, or both. 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| source | ACS Publications |
| subjects | Analytical chemistry Chemical compounds Chemistry Exact sciences and technology Ions Molecules Oxygen Scientific imaging Spectrometric and optical methods |
| title | Ion−Molecule Reactions for Mass Spectrometric Identification of Functional Groups in Protonated Oxygen-Containing Monofunctional Compounds |
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