Impact of Preoperative Fine-needle Aspiration Cytologic Examination on Clinical Outcome in Patients With Hepatocellular Carcinoma in a Tertiary Referral Center
HYPOTHESIS Preoperative fine-needle aspiration cytologic examination (FNAC) exerts a statistically significant adverse effect on long-term clinical outcome in patients with hepatocellular carcinoma (HCC). DESIGN Retrospective study. SETTING Tertiary referral center. PATIENTS A total of 828 patients...
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| Veröffentlicht in: | Archives of surgery (Chicago. 1960) 2004-02, Vol.139 (2), p.193-200 |
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| creator | Ng, Kelvin Kwok-Chai Poon, Ronnie Tung-Ping Lo, Chung-Mau Liu, Chi-Leung Lam, Chi-Ming Ng, Irene Oi-Lin Fan, Sheung-Tat |
| description | HYPOTHESIS Preoperative fine-needle aspiration cytologic examination (FNAC) exerts a statistically significant adverse effect on long-term clinical outcome in patients with hepatocellular carcinoma (HCC). DESIGN Retrospective study. SETTING Tertiary referral center. PATIENTS A total of 828 patients with clinical suggestion of HCC received surgical treatment. Ninety-one patients underwent preoperative FNAC, suggesting HCC, and 737 patients did not. MAIN OUTCOME MEASURES The resectability and histologic diagnoses of liver masses were evaluated in patients with and without preoperative FNAC. Clinicopathologic data and operative and survival outcomes of patients who underwent curative hepatic resection for HCC were compared between the FNAC and non-FNAC groups. RESULTS The resectability rates of the FNAC (81.3%) and non-FNAC (81.8%) groups did not differ (P = .91). Histologic examination of tumor confirmed HCC in 766 patients. The positive predictive value of preoperative FNAC was 96%, whereas that of preoperative imaging studies was 92% (P = .23). Among patients with nondiagnostic serum α-fetoprotein concentrations (≤400 ng/mL), 3% in the FNAC group (n = 66) had benign liver diseases vs 9.5% in the non-FNAC group (n = 432) (P = .09). Among patients with curative hepatic resection (70 in the FNAC group and 545 in the non-FNAC group), hospital mortality was 4% and 6% in the FNAC and non-FNAC groups, respectively. In the FNAC group, needle tract tumor seeding was not encountered. Excluding patients with preexisting and iatrogenic tumor rupture, intraperitoneal extrahepatic metastasis occurred in 1 patient (2%) in the FNAC group and in 30 (6%) in the non-FNAC group (P = .34). The cumulative 1-, 3-, and 5-year overall survival rates were 79%, 61%, and 48%, respectively, for the FNAC group and 75%, 55%, and 43% for the non-FNAC group (P = .77). The disease-free survival results of the groups were similar (P = .51). CONCLUSIONS Preoperative FNAC has no statistically significant adverse effect on the operability, the possibility of extrahepatic tumor spread, or the long-term survival of patients with HCC. Preoperative FNAC may play a diagnostic role in selected patients with liver nodules on imaging studies when the serum α-fetoprotein concentration is not diagnostic.Arch Surg. 2004;139:193-200--> |
| doi_str_mv | 10.1001/archsurg.139.2.193 |
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DESIGN Retrospective study. SETTING Tertiary referral center. PATIENTS A total of 828 patients with clinical suggestion of HCC received surgical treatment. Ninety-one patients underwent preoperative FNAC, suggesting HCC, and 737 patients did not. MAIN OUTCOME MEASURES The resectability and histologic diagnoses of liver masses were evaluated in patients with and without preoperative FNAC. Clinicopathologic data and operative and survival outcomes of patients who underwent curative hepatic resection for HCC were compared between the FNAC and non-FNAC groups. RESULTS The resectability rates of the FNAC (81.3%) and non-FNAC (81.8%) groups did not differ (P = .91). Histologic examination of tumor confirmed HCC in 766 patients. The positive predictive value of preoperative FNAC was 96%, whereas that of preoperative imaging studies was 92% (P = .23). Among patients with nondiagnostic serum α-fetoprotein concentrations (≤400 ng/mL), 3% in the FNAC group (n = 66) had benign liver diseases vs 9.5% in the non-FNAC group (n = 432) (P = .09). Among patients with curative hepatic resection (70 in the FNAC group and 545 in the non-FNAC group), hospital mortality was 4% and 6% in the FNAC and non-FNAC groups, respectively. In the FNAC group, needle tract tumor seeding was not encountered. Excluding patients with preexisting and iatrogenic tumor rupture, intraperitoneal extrahepatic metastasis occurred in 1 patient (2%) in the FNAC group and in 30 (6%) in the non-FNAC group (P = .34). The cumulative 1-, 3-, and 5-year overall survival rates were 79%, 61%, and 48%, respectively, for the FNAC group and 75%, 55%, and 43% for the non-FNAC group (P = .77). The disease-free survival results of the groups were similar (P = .51). CONCLUSIONS Preoperative FNAC has no statistically significant adverse effect on the operability, the possibility of extrahepatic tumor spread, or the long-term survival of patients with HCC. Preoperative FNAC may play a diagnostic role in selected patients with liver nodules on imaging studies when the serum α-fetoprotein concentration is not diagnostic.Arch Surg. 2004;139:193-200--></description><identifier>ISSN: 0004-0010</identifier><identifier>ISSN: 2168-6254</identifier><identifier>EISSN: 1538-3644</identifier><identifier>EISSN: 2168-6262</identifier><identifier>DOI: 10.1001/archsurg.139.2.193</identifier><identifier>PMID: 14769580</identifier><identifier>CODEN: ARSUAX</identifier><language>eng</language><publisher>Chicago, IL: American Medical Association</publisher><subject>Adult ; Aged ; Analysis of Variance ; Biological and medical sciences ; Biopsy, Needle - adverse effects ; Biopsy, Needle - methods ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Case-Control Studies ; Clinical outcomes ; Confidence Intervals ; Disease-Free Survival ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Hepatectomy - methods ; Hepatectomy - mortality ; Humans ; Immunohistochemistry ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Neoplasm Seeding ; Neoplastic Cells, Circulating - pathology ; Preoperative Care - methods ; Probability ; Prognosis ; Proportional Hazards Models ; Reference Values ; Referral and Consultation ; Retrospective Studies ; Risk Assessment ; Survival Analysis ; Treatment Outcome ; Tumors</subject><ispartof>Archives of surgery (Chicago. 1960), 2004-02, Vol.139 (2), p.193-200</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright American Medical Association Feb 2004</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a374t-e5e95312e4b8f939c578f3ba484827043bb6a2bc466df8cd420fc04b3bac53263</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jamasurgery/articlepdf/10.1001/archsurg.139.2.193$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jamasurgery/fullarticle/10.1001/archsurg.139.2.193$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,314,776,780,3326,27903,27904,76236,76239</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15942294$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14769580$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ng, Kelvin Kwok-Chai</creatorcontrib><creatorcontrib>Poon, Ronnie Tung-Ping</creatorcontrib><creatorcontrib>Lo, Chung-Mau</creatorcontrib><creatorcontrib>Liu, Chi-Leung</creatorcontrib><creatorcontrib>Lam, Chi-Ming</creatorcontrib><creatorcontrib>Ng, Irene Oi-Lin</creatorcontrib><creatorcontrib>Fan, Sheung-Tat</creatorcontrib><title>Impact of Preoperative Fine-needle Aspiration Cytologic Examination on Clinical Outcome in Patients With Hepatocellular Carcinoma in a Tertiary Referral Center</title><title>Archives of surgery (Chicago. 1960)</title><addtitle>Arch Surg</addtitle><description>HYPOTHESIS Preoperative fine-needle aspiration cytologic examination (FNAC) exerts a statistically significant adverse effect on long-term clinical outcome in patients with hepatocellular carcinoma (HCC). DESIGN Retrospective study. SETTING Tertiary referral center. PATIENTS A total of 828 patients with clinical suggestion of HCC received surgical treatment. Ninety-one patients underwent preoperative FNAC, suggesting HCC, and 737 patients did not. MAIN OUTCOME MEASURES The resectability and histologic diagnoses of liver masses were evaluated in patients with and without preoperative FNAC. Clinicopathologic data and operative and survival outcomes of patients who underwent curative hepatic resection for HCC were compared between the FNAC and non-FNAC groups. RESULTS The resectability rates of the FNAC (81.3%) and non-FNAC (81.8%) groups did not differ (P = .91). Histologic examination of tumor confirmed HCC in 766 patients. The positive predictive value of preoperative FNAC was 96%, whereas that of preoperative imaging studies was 92% (P = .23). Among patients with nondiagnostic serum α-fetoprotein concentrations (≤400 ng/mL), 3% in the FNAC group (n = 66) had benign liver diseases vs 9.5% in the non-FNAC group (n = 432) (P = .09). Among patients with curative hepatic resection (70 in the FNAC group and 545 in the non-FNAC group), hospital mortality was 4% and 6% in the FNAC and non-FNAC groups, respectively. In the FNAC group, needle tract tumor seeding was not encountered. Excluding patients with preexisting and iatrogenic tumor rupture, intraperitoneal extrahepatic metastasis occurred in 1 patient (2%) in the FNAC group and in 30 (6%) in the non-FNAC group (P = .34). The cumulative 1-, 3-, and 5-year overall survival rates were 79%, 61%, and 48%, respectively, for the FNAC group and 75%, 55%, and 43% for the non-FNAC group (P = .77). The disease-free survival results of the groups were similar (P = .51). CONCLUSIONS Preoperative FNAC has no statistically significant adverse effect on the operability, the possibility of extrahepatic tumor spread, or the long-term survival of patients with HCC. Preoperative FNAC may play a diagnostic role in selected patients with liver nodules on imaging studies when the serum α-fetoprotein concentration is not diagnostic.Arch Surg. 2004;139:193-200--></description><subject>Adult</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle - adverse effects</subject><subject>Biopsy, Needle - methods</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Case-Control Studies</subject><subject>Clinical outcomes</subject><subject>Confidence Intervals</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Hepatectomy - methods</subject><subject>Hepatectomy - mortality</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Seeding</subject><subject>Neoplastic Cells, Circulating - pathology</subject><subject>Preoperative Care - methods</subject><subject>Probability</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Reference Values</subject><subject>Referral and Consultation</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0004-0010</issn><issn>2168-6254</issn><issn>1538-3644</issn><issn>2168-6262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd9KHDEUxkNpqVvtA7QXJRTs3az5Ozu5lEGrICjF0suQyZ7RyEwyTTKlPk1f1Qy7VfAq4Zzf952TfAh9pmRNCaEnJtr7NMe7NeVqzdZU8TdoRSVvKl4L8RatCCGiKiQ5QB9Seig31ij2Hh1QsamVbMgK_bscJ2MzDj2-iRAmiCa7P4DPnYfKA2wHwKdpcks5eNw-5jCEO2fx2V8zOr-rLo3BeWfNgK_nbMMI2Hl8U7rgc8K_XL7HFzCZHCwMwzyYiNuyvfNhNAtp8C3E7Ex8xD-ghxiLUVukEI_Qu94MCT7uz0P08_zstr2orq6_X7anV5XhG5ErkKAkpwxE1_SKKys3Tc87IxrRsA0RvOtqwzor6nrbN3YrGOktEV1BrOSs5ofo2853iuH3DCnr0aVlWeMhzEk3hEpKJSvg11fgQ5ijL7tpxpmUNRGiQGwH2RhSitDrKbqxPE9Topfs9P_sdMlOM12yK6Ive-e5G2H7ItmHVYDjPWBS-eo-Gm9deuGkEoypZfqnHWdG89zlqua14k-ZPa6q</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Ng, Kelvin Kwok-Chai</creator><creator>Poon, Ronnie Tung-Ping</creator><creator>Lo, Chung-Mau</creator><creator>Liu, Chi-Leung</creator><creator>Lam, Chi-Ming</creator><creator>Ng, Irene Oi-Lin</creator><creator>Fan, Sheung-Tat</creator><general>American Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>Impact of Preoperative Fine-needle Aspiration Cytologic Examination on Clinical Outcome in Patients With Hepatocellular Carcinoma in a Tertiary Referral Center</title><author>Ng, Kelvin Kwok-Chai ; Poon, Ronnie Tung-Ping ; Lo, Chung-Mau ; Liu, Chi-Leung ; Lam, Chi-Ming ; Ng, Irene Oi-Lin ; Fan, Sheung-Tat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a374t-e5e95312e4b8f939c578f3ba484827043bb6a2bc466df8cd420fc04b3bac53263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle - adverse effects</topic><topic>Biopsy, Needle - methods</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Case-Control Studies</topic><topic>Clinical outcomes</topic><topic>Confidence Intervals</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>Hepatectomy - methods</topic><topic>Hepatectomy - mortality</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Seeding</topic><topic>Neoplastic Cells, Circulating - pathology</topic><topic>Preoperative Care - methods</topic><topic>Probability</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Reference Values</topic><topic>Referral and Consultation</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>Ng, Kelvin Kwok-Chai</creatorcontrib><creatorcontrib>Poon, Ronnie Tung-Ping</creatorcontrib><creatorcontrib>Lo, Chung-Mau</creatorcontrib><creatorcontrib>Liu, Chi-Leung</creatorcontrib><creatorcontrib>Lam, Chi-Ming</creatorcontrib><creatorcontrib>Ng, Irene Oi-Lin</creatorcontrib><creatorcontrib>Fan, Sheung-Tat</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of surgery (Chicago. 1960)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ng, Kelvin Kwok-Chai</au><au>Poon, Ronnie Tung-Ping</au><au>Lo, Chung-Mau</au><au>Liu, Chi-Leung</au><au>Lam, Chi-Ming</au><au>Ng, Irene Oi-Lin</au><au>Fan, Sheung-Tat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Preoperative Fine-needle Aspiration Cytologic Examination on Clinical Outcome in Patients With Hepatocellular Carcinoma in a Tertiary Referral Center</atitle><jtitle>Archives of surgery (Chicago. 1960)</jtitle><addtitle>Arch Surg</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>139</volume><issue>2</issue><spage>193</spage><epage>200</epage><pages>193-200</pages><issn>0004-0010</issn><issn>2168-6254</issn><eissn>1538-3644</eissn><eissn>2168-6262</eissn><coden>ARSUAX</coden><abstract>HYPOTHESIS Preoperative fine-needle aspiration cytologic examination (FNAC) exerts a statistically significant adverse effect on long-term clinical outcome in patients with hepatocellular carcinoma (HCC). DESIGN Retrospective study. SETTING Tertiary referral center. PATIENTS A total of 828 patients with clinical suggestion of HCC received surgical treatment. Ninety-one patients underwent preoperative FNAC, suggesting HCC, and 737 patients did not. MAIN OUTCOME MEASURES The resectability and histologic diagnoses of liver masses were evaluated in patients with and without preoperative FNAC. Clinicopathologic data and operative and survival outcomes of patients who underwent curative hepatic resection for HCC were compared between the FNAC and non-FNAC groups. RESULTS The resectability rates of the FNAC (81.3%) and non-FNAC (81.8%) groups did not differ (P = .91). Histologic examination of tumor confirmed HCC in 766 patients. The positive predictive value of preoperative FNAC was 96%, whereas that of preoperative imaging studies was 92% (P = .23). Among patients with nondiagnostic serum α-fetoprotein concentrations (≤400 ng/mL), 3% in the FNAC group (n = 66) had benign liver diseases vs 9.5% in the non-FNAC group (n = 432) (P = .09). Among patients with curative hepatic resection (70 in the FNAC group and 545 in the non-FNAC group), hospital mortality was 4% and 6% in the FNAC and non-FNAC groups, respectively. In the FNAC group, needle tract tumor seeding was not encountered. Excluding patients with preexisting and iatrogenic tumor rupture, intraperitoneal extrahepatic metastasis occurred in 1 patient (2%) in the FNAC group and in 30 (6%) in the non-FNAC group (P = .34). The cumulative 1-, 3-, and 5-year overall survival rates were 79%, 61%, and 48%, respectively, for the FNAC group and 75%, 55%, and 43% for the non-FNAC group (P = .77). The disease-free survival results of the groups were similar (P = .51). CONCLUSIONS Preoperative FNAC has no statistically significant adverse effect on the operability, the possibility of extrahepatic tumor spread, or the long-term survival of patients with HCC. Preoperative FNAC may play a diagnostic role in selected patients with liver nodules on imaging studies when the serum α-fetoprotein concentration is not diagnostic.Arch Surg. 2004;139:193-200--></abstract><cop>Chicago, IL</cop><pub>American Medical Association</pub><pmid>14769580</pmid><doi>10.1001/archsurg.139.2.193</doi><tpages>8</tpages></addata></record> |
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| ispartof | Archives of surgery (Chicago. 1960), 2004-02, Vol.139 (2), p.193-200 |
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| subjects | Adult Aged Analysis of Variance Biological and medical sciences Biopsy, Needle - adverse effects Biopsy, Needle - methods Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Case-Control Studies Clinical outcomes Confidence Intervals Disease-Free Survival Female Gastroenterology. Liver. Pancreas. Abdomen General aspects Hepatectomy - methods Hepatectomy - mortality Humans Immunohistochemistry Liver Neoplasms - mortality Liver Neoplasms - pathology Liver Neoplasms - surgery Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Multivariate Analysis Neoplasm Seeding Neoplastic Cells, Circulating - pathology Preoperative Care - methods Probability Prognosis Proportional Hazards Models Reference Values Referral and Consultation Retrospective Studies Risk Assessment Survival Analysis Treatment Outcome Tumors |
| title | Impact of Preoperative Fine-needle Aspiration Cytologic Examination on Clinical Outcome in Patients With Hepatocellular Carcinoma in a Tertiary Referral Center |
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