Emerging neuroskeletal signalling pathways: a review
Recent work has demonstrated that neurotransmitters, signalling molecules primarily associated with the nervous system, can have profound effects on the skeleton. Bone cells express a broad range of neurotransmitter receptors and transporters, and respond to receptor activation by initiating diverse...
Gespeichert in:
| Veröffentlicht in: | FEBS Letters 2004-02, Vol.559 (1), p.6-12 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 12 |
|---|---|
| container_issue | 1 |
| container_start_page | 6 |
| container_title | FEBS Letters |
| container_volume | 559 |
| creator | Spencer, Gary J Hitchcock, Ian S Genever, Paul G |
| description | Recent work has demonstrated that neurotransmitters, signalling molecules primarily associated with the nervous system, can have profound effects on the skeleton. Bone cells express a broad range of neurotransmitter receptors and transporters, and respond to receptor activation by initiating diverse intracellular signalling pathways, which modulate cellular function. Evidence of neuronal innervation in skeletal tissues, neurotransmitter release directly from bone cells and functional effects of pharmacological manipulation support the existence of a complex and functionally significant neurotransmitter-mediated signalling network in bone. This review aims to concisely summarise our current understanding of how neurotransmitters affect the skeletal system, focusing on their origin, cellular targets and functional effects in bone. |
| doi_str_mv | 10.1016/S0014-5793(04)00053-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80151095</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0014579304000535</els_id><sourcerecordid>80151095</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5565-d474bb4b0a77811ffe0c4171d5eb3d11872d8baacdac8887d52b098734fb6f083</originalsourceid><addsrcrecordid>eNqNkM1O6zAQhS0EgvLzCKCuEHeRy0xjxw4bBKj8SEgsgLXl2JNiSNNit1R9--u0FXcJK0s-n-eMP8aOEf4iYHH-DIA8E7LMz4D_AQCRZ2KL9VDJPMt5obZZ7xvZY_sxvicIFZa7bA95WcCgLHuMD8cURr4d9Vuah0n8oIZmpulHP2pN03TB1MzeFmYZL_qmH-jL0-KQ7dSmiXS0OQ_Y6-3w5eY-e3y6e7i5esysEIXIHJe8qngFRkqFWNcElqNEJ6jKHaZNB05VxlhnrFJKOjGooEz787oqalD5ATtdz52Gyeec4kyPfbTUNKalyTxqBSgQSvEjiBKKZEgmUKxBm_4aA9V6GvzYhKVG0J1XvfKqO2kauF551V3ByaZgXo3J_X-1EZmA-zWw8A0tfzdV3w6vB6ukC4Cvrruuy_UoSmqT7qCj9dRacj6QnWk38T9s-w_Gl5p-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17060057</pqid></control><display><type>article</type><title>Emerging neuroskeletal signalling pathways: a review</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Spencer, Gary J ; Hitchcock, Ian S ; Genever, Paul G</creator><creatorcontrib>Spencer, Gary J ; Hitchcock, Ian S ; Genever, Paul G</creatorcontrib><description>Recent work has demonstrated that neurotransmitters, signalling molecules primarily associated with the nervous system, can have profound effects on the skeleton. Bone cells express a broad range of neurotransmitter receptors and transporters, and respond to receptor activation by initiating diverse intracellular signalling pathways, which modulate cellular function. Evidence of neuronal innervation in skeletal tissues, neurotransmitter release directly from bone cells and functional effects of pharmacological manipulation support the existence of a complex and functionally significant neurotransmitter-mediated signalling network in bone. This review aims to concisely summarise our current understanding of how neurotransmitters affect the skeletal system, focusing on their origin, cellular targets and functional effects in bone.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/S0014-5793(04)00053-5</identifier><identifier>PMID: 14960299</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Animals ; Bone ; Bone and Bones - cytology ; Bone and Bones - innervation ; Humans ; Marrow ; Nerve ; Neurons - physiology ; Neurotransmitter ; Neurotransmitter Agents - metabolism ; Neurotransmitter Agents - physiology ; Osteoblast ; Osteoclast ; Receptors, Neurotransmitter - metabolism ; Receptors, Neurotransmitter - physiology ; Signal Transduction</subject><ispartof>FEBS Letters, 2004-02, Vol.559 (1), p.6-12</ispartof><rights>2004</rights><rights>FEBS Letters 559 (2004) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5565-d474bb4b0a77811ffe0c4171d5eb3d11872d8baacdac8887d52b098734fb6f083</citedby><cites>FETCH-LOGICAL-c5565-d474bb4b0a77811ffe0c4171d5eb3d11872d8baacdac8887d52b098734fb6f083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2FS0014-5793%2804%2900053-5$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579304000535$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>313,314,776,780,788,1411,1427,3537,27899,27901,27902,45550,45551,46384,46808,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14960299$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spencer, Gary J</creatorcontrib><creatorcontrib>Hitchcock, Ian S</creatorcontrib><creatorcontrib>Genever, Paul G</creatorcontrib><title>Emerging neuroskeletal signalling pathways: a review</title><title>FEBS Letters</title><addtitle>FEBS Lett</addtitle><description>Recent work has demonstrated that neurotransmitters, signalling molecules primarily associated with the nervous system, can have profound effects on the skeleton. Bone cells express a broad range of neurotransmitter receptors and transporters, and respond to receptor activation by initiating diverse intracellular signalling pathways, which modulate cellular function. Evidence of neuronal innervation in skeletal tissues, neurotransmitter release directly from bone cells and functional effects of pharmacological manipulation support the existence of a complex and functionally significant neurotransmitter-mediated signalling network in bone. This review aims to concisely summarise our current understanding of how neurotransmitters affect the skeletal system, focusing on their origin, cellular targets and functional effects in bone.</description><subject>Animals</subject><subject>Bone</subject><subject>Bone and Bones - cytology</subject><subject>Bone and Bones - innervation</subject><subject>Humans</subject><subject>Marrow</subject><subject>Nerve</subject><subject>Neurons - physiology</subject><subject>Neurotransmitter</subject><subject>Neurotransmitter Agents - metabolism</subject><subject>Neurotransmitter Agents - physiology</subject><subject>Osteoblast</subject><subject>Osteoclast</subject><subject>Receptors, Neurotransmitter - metabolism</subject><subject>Receptors, Neurotransmitter - physiology</subject><subject>Signal Transduction</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1O6zAQhS0EgvLzCKCuEHeRy0xjxw4bBKj8SEgsgLXl2JNiSNNit1R9--u0FXcJK0s-n-eMP8aOEf4iYHH-DIA8E7LMz4D_AQCRZ2KL9VDJPMt5obZZ7xvZY_sxvicIFZa7bA95WcCgLHuMD8cURr4d9Vuah0n8oIZmpulHP2pN03TB1MzeFmYZL_qmH-jL0-KQ7dSmiXS0OQ_Y6-3w5eY-e3y6e7i5esysEIXIHJe8qngFRkqFWNcElqNEJ6jKHaZNB05VxlhnrFJKOjGooEz787oqalD5ATtdz52Gyeec4kyPfbTUNKalyTxqBSgQSvEjiBKKZEgmUKxBm_4aA9V6GvzYhKVG0J1XvfKqO2kauF551V3ByaZgXo3J_X-1EZmA-zWw8A0tfzdV3w6vB6ukC4Cvrruuy_UoSmqT7qCj9dRacj6QnWk38T9s-w_Gl5p-</recordid><startdate>20040213</startdate><enddate>20040213</enddate><creator>Spencer, Gary J</creator><creator>Hitchcock, Ian S</creator><creator>Genever, Paul G</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20040213</creationdate><title>Emerging neuroskeletal signalling pathways: a review</title><author>Spencer, Gary J ; Hitchcock, Ian S ; Genever, Paul G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5565-d474bb4b0a77811ffe0c4171d5eb3d11872d8baacdac8887d52b098734fb6f083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Bone</topic><topic>Bone and Bones - cytology</topic><topic>Bone and Bones - innervation</topic><topic>Humans</topic><topic>Marrow</topic><topic>Nerve</topic><topic>Neurons - physiology</topic><topic>Neurotransmitter</topic><topic>Neurotransmitter Agents - metabolism</topic><topic>Neurotransmitter Agents - physiology</topic><topic>Osteoblast</topic><topic>Osteoclast</topic><topic>Receptors, Neurotransmitter - metabolism</topic><topic>Receptors, Neurotransmitter - physiology</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spencer, Gary J</creatorcontrib><creatorcontrib>Hitchcock, Ian S</creatorcontrib><creatorcontrib>Genever, Paul G</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS Letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spencer, Gary J</au><au>Hitchcock, Ian S</au><au>Genever, Paul G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emerging neuroskeletal signalling pathways: a review</atitle><jtitle>FEBS Letters</jtitle><addtitle>FEBS Lett</addtitle><date>2004-02-13</date><risdate>2004</risdate><volume>559</volume><issue>1</issue><spage>6</spage><epage>12</epage><pages>6-12</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Recent work has demonstrated that neurotransmitters, signalling molecules primarily associated with the nervous system, can have profound effects on the skeleton. Bone cells express a broad range of neurotransmitter receptors and transporters, and respond to receptor activation by initiating diverse intracellular signalling pathways, which modulate cellular function. Evidence of neuronal innervation in skeletal tissues, neurotransmitter release directly from bone cells and functional effects of pharmacological manipulation support the existence of a complex and functionally significant neurotransmitter-mediated signalling network in bone. This review aims to concisely summarise our current understanding of how neurotransmitters affect the skeletal system, focusing on their origin, cellular targets and functional effects in bone.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>14960299</pmid><doi>10.1016/S0014-5793(04)00053-5</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS Letters, 2004-02, Vol.559 (1), p.6-12 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80151095 |
| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Bone Bone and Bones - cytology Bone and Bones - innervation Humans Marrow Nerve Neurons - physiology Neurotransmitter Neurotransmitter Agents - metabolism Neurotransmitter Agents - physiology Osteoblast Osteoclast Receptors, Neurotransmitter - metabolism Receptors, Neurotransmitter - physiology Signal Transduction |
| title | Emerging neuroskeletal signalling pathways: a review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T19%3A37%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Emerging%20neuroskeletal%20signalling%20pathways:%20a%20review&rft.jtitle=FEBS%20Letters&rft.au=Spencer,%20Gary%20J&rft.date=2004-02-13&rft.volume=559&rft.issue=1&rft.spage=6&rft.epage=12&rft.pages=6-12&rft.issn=0014-5793&rft.eissn=1873-3468&rft_id=info:doi/10.1016/S0014-5793(04)00053-5&rft_dat=%3Cproquest_cross%3E80151095%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17060057&rft_id=info:pmid/14960299&rft_els_id=S0014579304000535&rfr_iscdi=true |