Adjunctive therapy with bromocriptine in Parkinson's disease
Patients with moderately severe Parkinson's disease complicated by the adverse effects of chronic levodopa use benefited from the addition of bromocriptine (Parlodel; Sandoz) in doses up to 26 mg daily, which allowed an approximate 30% reduction of levodopa dose. This resulted in a significant...
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| Veröffentlicht in: | South African medical journal 1990-12, Vol.78 (11), p.680-685 |
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| container_title | South African medical journal |
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| creator | TEMLETT, J. A MING, A SALING, M FRITZ, V. U BLUMENFELD, A BILCHIK, T. R BECKER, A. L FOURIE, P. B REEF, H. E |
| description | Patients with moderately severe Parkinson's disease complicated by the adverse effects of chronic levodopa use benefited from the addition of bromocriptine (Parlodel; Sandoz) in doses up to 26 mg daily, which allowed an approximate 30% reduction of levodopa dose. This resulted in a significant decrease in the amount of levodopa side-effects while maintaining or improving the original parkinsonian clinical stage. Increased effectiveness in these patients was not associated with increased dosage beyond 25-30 mg daily. When the doses of bromocriptine were increased slowly, the adverse reactions were minor and usually transient. |
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A ; MING, A ; SALING, M ; FRITZ, V. U ; BLUMENFELD, A ; BILCHIK, T. R ; BECKER, A. L ; FOURIE, P. B ; REEF, H. E</creator><creatorcontrib>TEMLETT, J. A ; MING, A ; SALING, M ; FRITZ, V. U ; BLUMENFELD, A ; BILCHIK, T. R ; BECKER, A. L ; FOURIE, P. B ; REEF, H. E</creatorcontrib><description>Patients with moderately severe Parkinson's disease complicated by the adverse effects of chronic levodopa use benefited from the addition of bromocriptine (Parlodel; Sandoz) in doses up to 26 mg daily, which allowed an approximate 30% reduction of levodopa dose. This resulted in a significant decrease in the amount of levodopa side-effects while maintaining or improving the original parkinsonian clinical stage. Increased effectiveness in these patients was not associated with increased dosage beyond 25-30 mg daily. When the doses of bromocriptine were increased slowly, the adverse reactions were minor and usually transient.</description><identifier>ISSN: 0256-9574</identifier><identifier>PMID: 2251616</identifier><identifier>CODEN: SAMJAF</identifier><language>eng</language><publisher>Pinelands: Medical Association of South Africa</publisher><subject>Adult ; Aged ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Bromocriptine - administration & dosage ; Bromocriptine - therapeutic use ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Humans ; Levodopa - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Neuropharmacology ; Parkinson Disease - drug therapy ; Pharmacology. Drug treatments ; Time Factors ; Tropical medicine</subject><ispartof>South African medical journal, 1990-12, Vol.78 (11), p.680-685</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19696006$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2251616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TEMLETT, J. A</creatorcontrib><creatorcontrib>MING, A</creatorcontrib><creatorcontrib>SALING, M</creatorcontrib><creatorcontrib>FRITZ, V. U</creatorcontrib><creatorcontrib>BLUMENFELD, A</creatorcontrib><creatorcontrib>BILCHIK, T. R</creatorcontrib><creatorcontrib>BECKER, A. L</creatorcontrib><creatorcontrib>FOURIE, P. B</creatorcontrib><creatorcontrib>REEF, H. E</creatorcontrib><title>Adjunctive therapy with bromocriptine in Parkinson's disease</title><title>South African medical journal</title><addtitle>S Afr Med J</addtitle><description>Patients with moderately severe Parkinson's disease complicated by the adverse effects of chronic levodopa use benefited from the addition of bromocriptine (Parlodel; Sandoz) in doses up to 26 mg daily, which allowed an approximate 30% reduction of levodopa dose. This resulted in a significant decrease in the amount of levodopa side-effects while maintaining or improving the original parkinsonian clinical stage. Increased effectiveness in these patients was not associated with increased dosage beyond 25-30 mg daily. When the doses of bromocriptine were increased slowly, the adverse reactions were minor and usually transient.</description><subject>Adult</subject><subject>Aged</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Bromocriptine - administration & dosage</subject><subject>Bromocriptine - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Levodopa - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Parkinson Disease - drug therapy</subject><subject>Pharmacology. Drug treatments</subject><subject>Time Factors</subject><subject>Tropical medicine</subject><issn>0256-9574</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j0tLxDAYRbNQxnH0JwjdqKtCHs0L3AyDjsKALnRdvqQpk7FNa5Iq8-8dsLi6XM7hwj1DS0y5KDWX1QW6TOmAT51rsUALSjkRRCzRw7o5TMFm_-2KvHcRxmPx4_O-MHHoBxv9mH1whQ_FG8RPH9IQ7lPR-OQguSt03kKX3PWcK_Tx9Pi-eS53r9uXzXpXjpSJXCpTGQUGE0WUZVgAaXUjqZK44VQw50yjKK1EC6ICC5WhFlssJcOaEKYqtkJ3f7tjHL4ml3Ld-2Rd10Fww5RqhQnHUuuTeDOLk-ldU4_R9xCP9Xz3xG9nDslC10YI1qd_jWihBcaC_QIpjFwv</recordid><startdate>19901201</startdate><enddate>19901201</enddate><creator>TEMLETT, J. A</creator><creator>MING, A</creator><creator>SALING, M</creator><creator>FRITZ, V. U</creator><creator>BLUMENFELD, A</creator><creator>BILCHIK, T. R</creator><creator>BECKER, A. L</creator><creator>FOURIE, P. B</creator><creator>REEF, H. 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B</creatorcontrib><creatorcontrib>REEF, H. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>South African medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TEMLETT, J. A</au><au>MING, A</au><au>SALING, M</au><au>FRITZ, V. U</au><au>BLUMENFELD, A</au><au>BILCHIK, T. R</au><au>BECKER, A. L</au><au>FOURIE, P. B</au><au>REEF, H. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adjunctive therapy with bromocriptine in Parkinson's disease</atitle><jtitle>South African medical journal</jtitle><addtitle>S Afr Med J</addtitle><date>1990-12-01</date><risdate>1990</risdate><volume>78</volume><issue>11</issue><spage>680</spage><epage>685</epage><pages>680-685</pages><issn>0256-9574</issn><coden>SAMJAF</coden><abstract>Patients with moderately severe Parkinson's disease complicated by the adverse effects of chronic levodopa use benefited from the addition of bromocriptine (Parlodel; Sandoz) in doses up to 26 mg daily, which allowed an approximate 30% reduction of levodopa dose. This resulted in a significant decrease in the amount of levodopa side-effects while maintaining or improving the original parkinsonian clinical stage. Increased effectiveness in these patients was not associated with increased dosage beyond 25-30 mg daily. 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| ispartof | South African medical journal, 1990-12, Vol.78 (11), p.680-685 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Aged Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Bromocriptine - administration & dosage Bromocriptine - therapeutic use Double-Blind Method Drug Therapy, Combination Female Humans Levodopa - therapeutic use Male Medical sciences Middle Aged Neuropharmacology Parkinson Disease - drug therapy Pharmacology. Drug treatments Time Factors Tropical medicine |
| title | Adjunctive therapy with bromocriptine in Parkinson's disease |
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