FTY720 exerts differential effects on CD4+ and CD8+ T-lymphocyte subpopulations expressing chemokine and adhesion receptors

Background. FTY720 (FTY), a novel immunomodulator with the potential to improve immunosuppressive therapy after organ transplantation, is currently under clinical investigation. Previous experimental animal studies have shown that FTY has a unique mechanism of action associated with altered lymphocy...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2004-03, Vol.19 (3), p.702-713
Hauptverfasser:	Böhler, Torsten, Waiser, Johannes, Schuetz, Manuela, Neumayer, Hans H., Budde, Klemens
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences CCR5 CD62 ligand Cell Culture Techniques Double-Blind Method Emergency and intensive care: renal failure. Dialysis management Fingolimod Hydrochloride FTY Fundamental and applied biological sciences. Psychology Fundamental immunology human Humans Immunobiology Immunosuppressive Agents - pharmacology Intensive care medicine Kidney Transplantation - immunology Lymphocyte Count lymphocyte subpopulation Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Medical sciences Pharmacology. Drug treatments Propylene Glycols - pharmacology Receptors, Chemokine - metabolism Receptors, Leukocyte-Adhesion - metabolism renal transplantation Sphingosine - analogs & derivatives T-Lymphocytes - drug effects T-Lymphocytes - metabolism Urinary system
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