Clinical Implication of Idiopathic Plasmacytic Lymphadenopathy with Polyclonal Hypergammaglobulinemia: A Report of 16 Cases
Idiopathic plasmacytic lymphadenopathy (IPL) with polyclonal hyperimmunoglobulinemia is considered identical to multicentric Castleman's disease (MCD) reported in western countries. Clinically, both IPL and MCD are characterized by multicentric lymphadenopathy, prominent polyclonal hypergammagl...
Gespeichert in:
| Veröffentlicht in: | International journal of surgical pathology 2004-01, Vol.12 (1), p.25-30 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 30 |
|---|---|
| container_issue | 1 |
| container_start_page | 25 |
| container_title | International journal of surgical pathology |
| container_volume | 12 |
| creator | Kojima, Masaru Nakamura, Shigeo Shimizu, Kazuhiko Itoh, Hideaki Yamane, Yuko Murayama, Kayoko Tanaka, Hiroshi Sugihara, Shiro Shimano, Shunichi Sakata, Noriyuki Masawa, Nobuhide |
| description | Idiopathic plasmacytic lymphadenopathy (IPL) with polyclonal hyperimmunoglobulinemia is considered identical to multicentric Castleman's disease (MCD) reported in western countries. Clinically, both IPL and MCD are characterized by multicentric lymphadenopathy, prominent polyclonal hypergammaglobulinemia, elevated erythrocyte sedimentation rate, elevated serum interleukin-6 concentration, bone marrow plasmacytosis, and various abnormal laboratory data such as anemia and positive autoantibodies. However, IPL has a significantly better 5-year survival rate than that of MCD. Moreover, none of the present 16 cases developed Kaposi's sarcoma or B-cell lymphoma. Histologically, the interfollicular area contains a sheet of polytypic mature plasma cells in both IPL and MCD. In MCD, the majority of lymphoid follicles had hyaline-vascular germinal centers. However, lymphoid follicles of IPL usually exhibit a hyperplastic germinal center. Immunostaining also demonstrated a normal/ reactive follicular dendritic cell network pattern in the germinal center of IPL. Moreover, there were no human herpes virus-8-positive cells detected by immunohistochemistry. The overall clinicopathologic and immunohistochemical findings of our 16 cases suggest that IPL is distinct from MCD reported in Western countries. |
| doi_str_mv | 10.1177/106689690401200104 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_80149697</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A113609545</galeid><sage_id>10.1177_106689690401200104</sage_id><sourcerecordid>A113609545</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-a0c093fa820138dfa1ce29e74d8d8af7926e9a597228298433a628237f5e43f53</originalsourceid><addsrcrecordid>eNqFklGL1DAUhYso7rr6B3yQ4oNv3U3SNG18GwbdHRhwEX0ud9ObTpakqUmLFP-86c7Agi5KHnJIvnNIDjfL3lJySWldX1EiRCOFJJxQRggl_Fl2TiUnBeOiep50AoqVOMtexXhPCGGC0ZfZGeW1qJiQ59mvrTWDUWDznRttEpPxQ-51vuuMH2E6GJXfWogO1DIlvV_ceIAOh4fLJf9ppkN-6-2irB9Sys0yYujBOeitv5tTODoDH_NN_hVHH6Y1mop8CxHj6-yFBhvxzWm_yL5__vRte1Psv1zvtpt9oXjNpwKIIrLU0DBCy6bTQBUyiTXvmq4BXUsmUEIla8YaJhteliCSKmtdIS91VV5kH465Y_A_ZoxT60xUaC0M6OfYNoTyVFL9X5BRKktJeQLf_wHe-zmk_68MT1CqN0HFEerBYmsG7acAqscBA6SyUJt0vKG0FERWfOUvn-DT6lKF6kkDOxpU8DEG1O0YjIOwtJS064S0f09IMr07PX2-c9g9Wk4jkYCrIxChx8d__SPyNx2Cwh0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>214193765</pqid></control><display><type>article</type><title>Clinical Implication of Idiopathic Plasmacytic Lymphadenopathy with Polyclonal Hypergammaglobulinemia: A Report of 16 Cases</title><source>SAGE Complete A-Z List</source><source>MEDLINE</source><creator>Kojima, Masaru ; Nakamura, Shigeo ; Shimizu, Kazuhiko ; Itoh, Hideaki ; Yamane, Yuko ; Murayama, Kayoko ; Tanaka, Hiroshi ; Sugihara, Shiro ; Shimano, Shunichi ; Sakata, Noriyuki ; Masawa, Nobuhide</creator><creatorcontrib>Kojima, Masaru ; Nakamura, Shigeo ; Shimizu, Kazuhiko ; Itoh, Hideaki ; Yamane, Yuko ; Murayama, Kayoko ; Tanaka, Hiroshi ; Sugihara, Shiro ; Shimano, Shunichi ; Sakata, Noriyuki ; Masawa, Nobuhide</creatorcontrib><description>Idiopathic plasmacytic lymphadenopathy (IPL) with polyclonal hyperimmunoglobulinemia is considered identical to multicentric Castleman's disease (MCD) reported in western countries. Clinically, both IPL and MCD are characterized by multicentric lymphadenopathy, prominent polyclonal hypergammaglobulinemia, elevated erythrocyte sedimentation rate, elevated serum interleukin-6 concentration, bone marrow plasmacytosis, and various abnormal laboratory data such as anemia and positive autoantibodies. However, IPL has a significantly better 5-year survival rate than that of MCD. Moreover, none of the present 16 cases developed Kaposi's sarcoma or B-cell lymphoma. Histologically, the interfollicular area contains a sheet of polytypic mature plasma cells in both IPL and MCD. In MCD, the majority of lymphoid follicles had hyaline-vascular germinal centers. However, lymphoid follicles of IPL usually exhibit a hyperplastic germinal center. Immunostaining also demonstrated a normal/ reactive follicular dendritic cell network pattern in the germinal center of IPL. Moreover, there were no human herpes virus-8-positive cells detected by immunohistochemistry. The overall clinicopathologic and immunohistochemical findings of our 16 cases suggest that IPL is distinct from MCD reported in Western countries.</description><identifier>ISSN: 1066-8969</identifier><identifier>EISSN: 1940-2465</identifier><identifier>DOI: 10.1177/106689690401200104</identifier><identifier>PMID: 14765269</identifier><identifier>CODEN: IJSPFL</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Adult ; Aged ; Castleman Disease - mortality ; Castleman Disease - pathology ; Castleman Disease - virology ; Diagnosis, Differential ; Female ; Herpesvirus 4, Human - isolation & purification ; Humans ; Hypergammaglobulinemia - mortality ; Hypergammaglobulinemia - pathology ; Hypergammaglobulinemia - virology ; Immunohistochemistry ; In Situ Hybridization ; Lymphatic Diseases - mortality ; Lymphatic Diseases - pathology ; Lymphatic Diseases - virology ; Male ; Middle Aged ; Plasma Cells - pathology</subject><ispartof>International journal of surgical pathology, 2004-01, Vol.12 (1), p.25-30</ispartof><rights>COPYRIGHT 2004 Sage Publications, Inc.</rights><rights>Copyright Westminster Publications, Inc. Jan 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-a0c093fa820138dfa1ce29e74d8d8af7926e9a597228298433a628237f5e43f53</citedby><cites>FETCH-LOGICAL-c474t-a0c093fa820138dfa1ce29e74d8d8af7926e9a597228298433a628237f5e43f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/106689690401200104$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/106689690401200104$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14765269$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kojima, Masaru</creatorcontrib><creatorcontrib>Nakamura, Shigeo</creatorcontrib><creatorcontrib>Shimizu, Kazuhiko</creatorcontrib><creatorcontrib>Itoh, Hideaki</creatorcontrib><creatorcontrib>Yamane, Yuko</creatorcontrib><creatorcontrib>Murayama, Kayoko</creatorcontrib><creatorcontrib>Tanaka, Hiroshi</creatorcontrib><creatorcontrib>Sugihara, Shiro</creatorcontrib><creatorcontrib>Shimano, Shunichi</creatorcontrib><creatorcontrib>Sakata, Noriyuki</creatorcontrib><creatorcontrib>Masawa, Nobuhide</creatorcontrib><title>Clinical Implication of Idiopathic Plasmacytic Lymphadenopathy with Polyclonal Hypergammaglobulinemia: A Report of 16 Cases</title><title>International journal of surgical pathology</title><addtitle>Int J Surg Pathol</addtitle><description>Idiopathic plasmacytic lymphadenopathy (IPL) with polyclonal hyperimmunoglobulinemia is considered identical to multicentric Castleman's disease (MCD) reported in western countries. Clinically, both IPL and MCD are characterized by multicentric lymphadenopathy, prominent polyclonal hypergammaglobulinemia, elevated erythrocyte sedimentation rate, elevated serum interleukin-6 concentration, bone marrow plasmacytosis, and various abnormal laboratory data such as anemia and positive autoantibodies. However, IPL has a significantly better 5-year survival rate than that of MCD. Moreover, none of the present 16 cases developed Kaposi's sarcoma or B-cell lymphoma. Histologically, the interfollicular area contains a sheet of polytypic mature plasma cells in both IPL and MCD. In MCD, the majority of lymphoid follicles had hyaline-vascular germinal centers. However, lymphoid follicles of IPL usually exhibit a hyperplastic germinal center. Immunostaining also demonstrated a normal/ reactive follicular dendritic cell network pattern in the germinal center of IPL. Moreover, there were no human herpes virus-8-positive cells detected by immunohistochemistry. The overall clinicopathologic and immunohistochemical findings of our 16 cases suggest that IPL is distinct from MCD reported in Western countries.</description><subject>Adult</subject><subject>Aged</subject><subject>Castleman Disease - mortality</subject><subject>Castleman Disease - pathology</subject><subject>Castleman Disease - virology</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Herpesvirus 4, Human - isolation & purification</subject><subject>Humans</subject><subject>Hypergammaglobulinemia - mortality</subject><subject>Hypergammaglobulinemia - pathology</subject><subject>Hypergammaglobulinemia - virology</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Lymphatic Diseases - mortality</subject><subject>Lymphatic Diseases - pathology</subject><subject>Lymphatic Diseases - virology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Plasma Cells - pathology</subject><issn>1066-8969</issn><issn>1940-2465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFklGL1DAUhYso7rr6B3yQ4oNv3U3SNG18GwbdHRhwEX0ud9ObTpakqUmLFP-86c7Agi5KHnJIvnNIDjfL3lJySWldX1EiRCOFJJxQRggl_Fl2TiUnBeOiep50AoqVOMtexXhPCGGC0ZfZGeW1qJiQ59mvrTWDUWDznRttEpPxQ-51vuuMH2E6GJXfWogO1DIlvV_ceIAOh4fLJf9ppkN-6-2irB9Sys0yYujBOeitv5tTODoDH_NN_hVHH6Y1mop8CxHj6-yFBhvxzWm_yL5__vRte1Psv1zvtpt9oXjNpwKIIrLU0DBCy6bTQBUyiTXvmq4BXUsmUEIla8YaJhteliCSKmtdIS91VV5kH465Y_A_ZoxT60xUaC0M6OfYNoTyVFL9X5BRKktJeQLf_wHe-zmk_68MT1CqN0HFEerBYmsG7acAqscBA6SyUJt0vKG0FERWfOUvn-DT6lKF6kkDOxpU8DEG1O0YjIOwtJS064S0f09IMr07PX2-c9g9Wk4jkYCrIxChx8d__SPyNx2Cwh0</recordid><startdate>200401</startdate><enddate>200401</enddate><creator>Kojima, Masaru</creator><creator>Nakamura, Shigeo</creator><creator>Shimizu, Kazuhiko</creator><creator>Itoh, Hideaki</creator><creator>Yamane, Yuko</creator><creator>Murayama, Kayoko</creator><creator>Tanaka, Hiroshi</creator><creator>Sugihara, Shiro</creator><creator>Shimano, Shunichi</creator><creator>Sakata, Noriyuki</creator><creator>Masawa, Nobuhide</creator><general>SAGE Publications</general><general>Sage Publications, Inc</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200401</creationdate><title>Clinical Implication of Idiopathic Plasmacytic Lymphadenopathy with Polyclonal Hypergammaglobulinemia: A Report of 16 Cases</title><author>Kojima, Masaru ; Nakamura, Shigeo ; Shimizu, Kazuhiko ; Itoh, Hideaki ; Yamane, Yuko ; Murayama, Kayoko ; Tanaka, Hiroshi ; Sugihara, Shiro ; Shimano, Shunichi ; Sakata, Noriyuki ; Masawa, Nobuhide</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-a0c093fa820138dfa1ce29e74d8d8af7926e9a597228298433a628237f5e43f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Castleman Disease - mortality</topic><topic>Castleman Disease - pathology</topic><topic>Castleman Disease - virology</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Herpesvirus 4, Human - isolation & purification</topic><topic>Humans</topic><topic>Hypergammaglobulinemia - mortality</topic><topic>Hypergammaglobulinemia - pathology</topic><topic>Hypergammaglobulinemia - virology</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Lymphatic Diseases - mortality</topic><topic>Lymphatic Diseases - pathology</topic><topic>Lymphatic Diseases - virology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Plasma Cells - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kojima, Masaru</creatorcontrib><creatorcontrib>Nakamura, Shigeo</creatorcontrib><creatorcontrib>Shimizu, Kazuhiko</creatorcontrib><creatorcontrib>Itoh, Hideaki</creatorcontrib><creatorcontrib>Yamane, Yuko</creatorcontrib><creatorcontrib>Murayama, Kayoko</creatorcontrib><creatorcontrib>Tanaka, Hiroshi</creatorcontrib><creatorcontrib>Sugihara, Shiro</creatorcontrib><creatorcontrib>Shimano, Shunichi</creatorcontrib><creatorcontrib>Sakata, Noriyuki</creatorcontrib><creatorcontrib>Masawa, Nobuhide</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kojima, Masaru</au><au>Nakamura, Shigeo</au><au>Shimizu, Kazuhiko</au><au>Itoh, Hideaki</au><au>Yamane, Yuko</au><au>Murayama, Kayoko</au><au>Tanaka, Hiroshi</au><au>Sugihara, Shiro</au><au>Shimano, Shunichi</au><au>Sakata, Noriyuki</au><au>Masawa, Nobuhide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Implication of Idiopathic Plasmacytic Lymphadenopathy with Polyclonal Hypergammaglobulinemia: A Report of 16 Cases</atitle><jtitle>International journal of surgical pathology</jtitle><addtitle>Int J Surg Pathol</addtitle><date>2004-01</date><risdate>2004</risdate><volume>12</volume><issue>1</issue><spage>25</spage><epage>30</epage><pages>25-30</pages><issn>1066-8969</issn><eissn>1940-2465</eissn><coden>IJSPFL</coden><abstract>Idiopathic plasmacytic lymphadenopathy (IPL) with polyclonal hyperimmunoglobulinemia is considered identical to multicentric Castleman's disease (MCD) reported in western countries. Clinically, both IPL and MCD are characterized by multicentric lymphadenopathy, prominent polyclonal hypergammaglobulinemia, elevated erythrocyte sedimentation rate, elevated serum interleukin-6 concentration, bone marrow plasmacytosis, and various abnormal laboratory data such as anemia and positive autoantibodies. However, IPL has a significantly better 5-year survival rate than that of MCD. Moreover, none of the present 16 cases developed Kaposi's sarcoma or B-cell lymphoma. Histologically, the interfollicular area contains a sheet of polytypic mature plasma cells in both IPL and MCD. In MCD, the majority of lymphoid follicles had hyaline-vascular germinal centers. However, lymphoid follicles of IPL usually exhibit a hyperplastic germinal center. Immunostaining also demonstrated a normal/ reactive follicular dendritic cell network pattern in the germinal center of IPL. Moreover, there were no human herpes virus-8-positive cells detected by immunohistochemistry. The overall clinicopathologic and immunohistochemical findings of our 16 cases suggest that IPL is distinct from MCD reported in Western countries.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>14765269</pmid><doi>10.1177/106689690401200104</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1066-8969 |
| ispartof | International journal of surgical pathology, 2004-01, Vol.12 (1), p.25-30 |
| issn | 1066-8969 1940-2465 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80149697 |
| source | SAGE Complete A-Z List; MEDLINE |
| subjects | Adult Aged Castleman Disease - mortality Castleman Disease - pathology Castleman Disease - virology Diagnosis, Differential Female Herpesvirus 4, Human - isolation & purification Humans Hypergammaglobulinemia - mortality Hypergammaglobulinemia - pathology Hypergammaglobulinemia - virology Immunohistochemistry In Situ Hybridization Lymphatic Diseases - mortality Lymphatic Diseases - pathology Lymphatic Diseases - virology Male Middle Aged Plasma Cells - pathology |
| title | Clinical Implication of Idiopathic Plasmacytic Lymphadenopathy with Polyclonal Hypergammaglobulinemia: A Report of 16 Cases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T19%3A36%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20Implication%20of%20Idiopathic%20Plasmacytic%20Lymphadenopathy%20with%20Polyclonal%20Hypergammaglobulinemia:%20A%20Report%20of%2016%20Cases&rft.jtitle=International%20journal%20of%20surgical%20pathology&rft.au=Kojima,%20Masaru&rft.date=2004-01&rft.volume=12&rft.issue=1&rft.spage=25&rft.epage=30&rft.pages=25-30&rft.issn=1066-8969&rft.eissn=1940-2465&rft.coden=IJSPFL&rft_id=info:doi/10.1177/106689690401200104&rft_dat=%3Cgale_proqu%3EA113609545%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=214193765&rft_id=info:pmid/14765269&rft_galeid=A113609545&rft_sage_id=10.1177_106689690401200104&rfr_iscdi=true |