The role of cholesterol and phosphatidylcholine on very low density lipoprotein secretion from rat hepatocytes
The role of cholesterol and phosphatidylcholine on hepatic very low density lipoprotein secretion was investigated with rat hepatocytes. Hepatic very low density lipoprotein secretion (apo B, apo E, cholesterol, triglyceride, phosphatidylcholine) was decreased by the reduction of hepatic phosphatidy...
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| Veröffentlicht in: | Nippon Shokakibyo Gakkai Zasshi 1990, Vol.87(10), pp.2393-2399 |
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| container_issue | 10 |
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| container_title | Nippon Shokakibyo Gakkai Zasshi |
| container_volume | 87 |
| creator | HAYASHI, Kozo NAKASHIMA, Koichiro DOJO, Shinya HIRATA, Yasuhiko OHTANI, Hiromasa SAEKI, Masayumi KURUSHIMA, Hitoshi NISHIO, Eisuke HIRAOKA, Masataka ITO, Masaki HORIUCHI, Itaru KAJIYAMA, Goro |
| description | The role of cholesterol and phosphatidylcholine on hepatic very low density lipoprotein secretion was investigated with rat hepatocytes. Hepatic very low density lipoprotein secretion (apo B, apo E, cholesterol, triglyceride, phosphatidylcholine) was decreased by the reduction of hepatic phosphatidylcholine content. However, cholesterol loading into hepatocytes did not affect hepatic very low density lipoprotein secretion. Hepatic apolipoprotein contents were constant and were not influenced by a change of hepatic cholesterol and phosphatidylcholine contents. These results suggest that lipids, which are constituents of lipoproteins, play different roles on hepatic very low density lipoprotein secretion. |
| doi_str_mv | 10.11405/nisshoshi1964.87.2393 |
| format | Article |
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Hepatic very low density lipoprotein secretion (apo B, apo E, cholesterol, triglyceride, phosphatidylcholine) was decreased by the reduction of hepatic phosphatidylcholine content. However, cholesterol loading into hepatocytes did not affect hepatic very low density lipoprotein secretion. Hepatic apolipoprotein contents were constant and were not influenced by a change of hepatic cholesterol and phosphatidylcholine contents. 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Hepatic very low density lipoprotein secretion (apo B, apo E, cholesterol, triglyceride, phosphatidylcholine) was decreased by the reduction of hepatic phosphatidylcholine content. However, cholesterol loading into hepatocytes did not affect hepatic very low density lipoprotein secretion. Hepatic apolipoprotein contents were constant and were not influenced by a change of hepatic cholesterol and phosphatidylcholine contents. These results suggest that lipids, which are constituents of lipoproteins, play different roles on hepatic very low density lipoprotein secretion.</description><subject>Animals</subject><subject>Cells, Cultured</subject><subject>Cholesterol - physiology</subject><subject>Lipoproteins, VLDL - secretion</subject><subject>Liver - cytology</subject><subject>Liver - secretion</subject><subject>Male</subject><subject>Phosphatidylcholines - physiology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0446-6586</issn><issn>1349-7693</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkVtLwzAUx4MoOqYfQcmTb50nTZqmjzK8wcCX-Vyy9NRGuqQmmbJvb2RD8OVc-P84V0JuGCwYE1DdORvj4ONgWSPFQtWLkjf8hMwYF01Ry4afkhkIIQtZKXlBrmK0GwBoqkZxfk7Oy7ICrmBG3HpAGvyI1PfUDDmICXNOtevolFtMg06224-_mnUZc_QLw56O_pt26KJNObaTn4JPaB2NaAImm7E--C0NOtEBJ5282SeMl-Ss12PEq6Ofk7fHh_XyuVi9Pr0s71fFRynqVJgeuRRMc9UY6JgpBW6gRtjIXnVMSd4DF9Bxo5lSGWO6qjVow0B2yKDmc3J7qJvH-tzlndqtjQbHUTv0u9gqYEI1CjJ4fQR3my127RTsVod9ezxQ1lcH_SMm_Y5_ug7JmhHbf49oVd0yONrfj_xhZtChRcd_AAGAiUE</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>HAYASHI, Kozo</creator><creator>NAKASHIMA, Koichiro</creator><creator>DOJO, Shinya</creator><creator>HIRATA, Yasuhiko</creator><creator>OHTANI, Hiromasa</creator><creator>SAEKI, Masayumi</creator><creator>KURUSHIMA, Hitoshi</creator><creator>NISHIO, Eisuke</creator><creator>HIRAOKA, Masataka</creator><creator>ITO, Masaki</creator><creator>HORIUCHI, Itaru</creator><creator>KAJIYAMA, Goro</creator><general>The Japanese Society of Gastroenterology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>The role of cholesterol and phosphatidylcholine on very low density lipoprotein secretion from rat hepatocytes</title><author>HAYASHI, Kozo ; NAKASHIMA, Koichiro ; DOJO, Shinya ; HIRATA, Yasuhiko ; OHTANI, Hiromasa ; SAEKI, Masayumi ; KURUSHIMA, Hitoshi ; NISHIO, Eisuke ; HIRAOKA, Masataka ; ITO, Masaki ; HORIUCHI, Itaru ; KAJIYAMA, Goro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j247t-cfe3641a389c0d1c24eb07e0b6f8d1863f0340d3ca1881a31a57a0ac106de1073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Cells, Cultured</topic><topic>Cholesterol - physiology</topic><topic>Lipoproteins, VLDL - secretion</topic><topic>Liver - cytology</topic><topic>Liver - secretion</topic><topic>Male</topic><topic>Phosphatidylcholines - physiology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>online_resources</toplevel><creatorcontrib>HAYASHI, Kozo</creatorcontrib><creatorcontrib>NAKASHIMA, Koichiro</creatorcontrib><creatorcontrib>DOJO, Shinya</creatorcontrib><creatorcontrib>HIRATA, Yasuhiko</creatorcontrib><creatorcontrib>OHTANI, Hiromasa</creatorcontrib><creatorcontrib>SAEKI, Masayumi</creatorcontrib><creatorcontrib>KURUSHIMA, Hitoshi</creatorcontrib><creatorcontrib>NISHIO, Eisuke</creatorcontrib><creatorcontrib>HIRAOKA, Masataka</creatorcontrib><creatorcontrib>ITO, Masaki</creatorcontrib><creatorcontrib>HORIUCHI, Itaru</creatorcontrib><creatorcontrib>KAJIYAMA, Goro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nippon Shokakibyo Gakkai Zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HAYASHI, Kozo</au><au>NAKASHIMA, Koichiro</au><au>DOJO, Shinya</au><au>HIRATA, Yasuhiko</au><au>OHTANI, Hiromasa</au><au>SAEKI, Masayumi</au><au>KURUSHIMA, Hitoshi</au><au>NISHIO, Eisuke</au><au>HIRAOKA, Masataka</au><au>ITO, Masaki</au><au>HORIUCHI, Itaru</au><au>KAJIYAMA, Goro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of cholesterol and phosphatidylcholine on very low density lipoprotein secretion from rat hepatocytes</atitle><jtitle>Nippon Shokakibyo Gakkai Zasshi</jtitle><addtitle>Nippon Shokakibyo Gakkai Zasshi</addtitle><date>1990</date><risdate>1990</risdate><volume>87</volume><issue>10</issue><spage>2393</spage><epage>2399</epage><pages>2393-2399</pages><issn>0446-6586</issn><eissn>1349-7693</eissn><abstract>The role of cholesterol and phosphatidylcholine on hepatic very low density lipoprotein secretion was investigated with rat hepatocytes. Hepatic very low density lipoprotein secretion (apo B, apo E, cholesterol, triglyceride, phosphatidylcholine) was decreased by the reduction of hepatic phosphatidylcholine content. However, cholesterol loading into hepatocytes did not affect hepatic very low density lipoprotein secretion. Hepatic apolipoprotein contents were constant and were not influenced by a change of hepatic cholesterol and phosphatidylcholine contents. These results suggest that lipids, which are constituents of lipoproteins, play different roles on hepatic very low density lipoprotein secretion.</abstract><cop>Japan</cop><pub>The Japanese Society of Gastroenterology</pub><pmid>2250380</pmid><doi>10.11405/nisshoshi1964.87.2393</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0446-6586 |
| ispartof | Nippon Shokakibyo Gakkai Zasshi, 1990, Vol.87(10), pp.2393-2399 |
| issn | 0446-6586 1349-7693 |
| language | jpn |
| recordid | cdi_proquest_miscellaneous_80148980 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Cells, Cultured Cholesterol - physiology Lipoproteins, VLDL - secretion Liver - cytology Liver - secretion Male Phosphatidylcholines - physiology Rats Rats, Inbred Strains |
| title | The role of cholesterol and phosphatidylcholine on very low density lipoprotein secretion from rat hepatocytes |
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