Targets of homeotic gene control in Drosophila
The homeotic gene Ultrabithorax (Ubx) encodes homeodomain-containing transcription factors that determine segmental identity in Drosophila. Here, an immunopurification procedure is described that enriches for embryonic chromatin fragments containing binding sites for Ubx protein. In two cases these...
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| Veröffentlicht in: | Nature (London) 1990-11, Vol.348 (6299), p.308-312 |
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| creator | Gould, A.P Brookman, J.J Strutt, D.I White, R.A.H |
| description | The homeotic gene Ultrabithorax (Ubx) encodes homeodomain-containing transcription factors that determine segmental identity in Drosophila. Here, an immunopurification procedure is described that enriches for embryonic chromatin fragments containing binding sites for Ubx protein. In two cases these binding sites are located near embryonic transcription units regulated by the Ubx locus in vivo. Thus, these transcripts may correspond to Ubx target genes involved in elaborating segment-specific developmental pathways. |
| doi_str_mv | 10.1038/348308a0 |
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Here, an immunopurification procedure is described that enriches for embryonic chromatin fragments containing binding sites for Ubx protein. In two cases these binding sites are located near embryonic transcription units regulated by the Ubx locus in vivo. Thus, these transcripts may correspond to Ubx target genes involved in elaborating segment-specific developmental pathways.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/348308a0</identifier><identifier>PMID: 1979146</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Animals ; Base Sequence ; Binding sites ; Biological and medical sciences ; Cellular biology ; Chromatin ; Chromatin - metabolism ; Chromatin - ultrastructure ; Classical genetics, quantitative genetics, hybrids ; Cloning ; Deoxyribonucleic acid ; DNA ; Drosophila ; Drosophila - embryology ; Drosophila - genetics ; Embryo, Nonmammalian - physiology ; Embryos ; Fundamental and applied biological sciences. Psychology ; Genes ; Genes, Homeobox ; genetic control ; Genetics ; Genetics of eukaryotes. Biological and molecular evolution ; genome ; Homeobox ; Insects ; Invertebrata ; Laboratories ; Molecular Sequence Data ; Proteins ; Reproduction ; transcription (genetics) ; Transcription factors ; Transcription, Genetic ; ultrabithorax gene</subject><ispartof>Nature (London), 1990-11, Vol.348 (6299), p.308-312</ispartof><rights>1991 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Nov 22, 1990</rights><rights>Copyright Nature Publishing Group Nov 22, 1990</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-38f3993b40c9971d9cae273df7e9247aa66bb107bdedc629f73ab3a1687109da3</citedby><cites>FETCH-LOGICAL-c419t-38f3993b40c9971d9cae273df7e9247aa66bb107bdedc629f73ab3a1687109da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19448418$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1979146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gould, A.P</creatorcontrib><creatorcontrib>Brookman, J.J</creatorcontrib><creatorcontrib>Strutt, D.I</creatorcontrib><creatorcontrib>White, R.A.H</creatorcontrib><title>Targets of homeotic gene control in Drosophila</title><title>Nature (London)</title><addtitle>Nature</addtitle><description>The homeotic gene Ultrabithorax (Ubx) encodes homeodomain-containing transcription factors that determine segmental identity in Drosophila. Here, an immunopurification procedure is described that enriches for embryonic chromatin fragments containing binding sites for Ubx protein. In two cases these binding sites are located near embryonic transcription units regulated by the Ubx locus in vivo. Thus, these transcripts may correspond to Ubx target genes involved in elaborating segment-specific developmental pathways.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Binding sites</subject><subject>Biological and medical sciences</subject><subject>Cellular biology</subject><subject>Chromatin</subject><subject>Chromatin - metabolism</subject><subject>Chromatin - ultrastructure</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Cloning</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drosophila</subject><subject>Drosophila - embryology</subject><subject>Drosophila - genetics</subject><subject>Embryo, Nonmammalian - physiology</subject><subject>Embryos</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes</subject><subject>Genes, Homeobox</subject><subject>genetic control</subject><subject>Genetics</subject><subject>Genetics of eukaryotes. 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Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gould, A.P</au><au>Brookman, J.J</au><au>Strutt, D.I</au><au>White, R.A.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targets of homeotic gene control in Drosophila</atitle><jtitle>Nature (London)</jtitle><addtitle>Nature</addtitle><date>1990-11-22</date><risdate>1990</risdate><volume>348</volume><issue>6299</issue><spage>308</spage><epage>312</epage><pages>308-312</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>The homeotic gene Ultrabithorax (Ubx) encodes homeodomain-containing transcription factors that determine segmental identity in Drosophila. Here, an immunopurification procedure is described that enriches for embryonic chromatin fragments containing binding sites for Ubx protein. In two cases these binding sites are located near embryonic transcription units regulated by the Ubx locus in vivo. Thus, these transcripts may correspond to Ubx target genes involved in elaborating segment-specific developmental pathways.</abstract><cop>London</cop><pub>Nature Publishing</pub><pmid>1979146</pmid><doi>10.1038/348308a0</doi><tpages>5</tpages></addata></record> |
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| ispartof | Nature (London), 1990-11, Vol.348 (6299), p.308-312 |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Animals Base Sequence Binding sites Biological and medical sciences Cellular biology Chromatin Chromatin - metabolism Chromatin - ultrastructure Classical genetics, quantitative genetics, hybrids Cloning Deoxyribonucleic acid DNA Drosophila Drosophila - embryology Drosophila - genetics Embryo, Nonmammalian - physiology Embryos Fundamental and applied biological sciences. Psychology Genes Genes, Homeobox genetic control Genetics Genetics of eukaryotes. Biological and molecular evolution genome Homeobox Insects Invertebrata Laboratories Molecular Sequence Data Proteins Reproduction transcription (genetics) Transcription factors Transcription, Genetic ultrabithorax gene |
| title | Targets of homeotic gene control in Drosophila |
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