Development and Evaluation of a Candidate Reference Method for the Determination of Total Cortisol in Human Serum Using Isotope Dilution Liquid Chromatography/Mass Spectrometry and Liquid Chromatography/Tandem Mass Spectrometry

Cortisol is an important diagnostic marker for the production of steroid hormones, and accurate measurements of serum cortisol are necessary for proper diagnosis of adrenal function. A candidate reference method involving isotope dilution coupled with liquid chromatography/mass spectrometry (LC/MS)...

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Veröffentlicht in:	Analytical chemistry (Washington) 2004-02, Vol.76 (4), p.1008-1014
Hauptverfasser:	Tai, Susan S.-C, Welch, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical biochemistry: general aspects, technics, instrumentation Analytical chemistry Analytical, structural and metabolic biochemistry Biological and medical sciences Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, Liquid - methods Deuterium Evaluation Studies as Topic Exact sciences and technology Fundamental and applied biological sciences. Psychology Humans Hydrocortisone - blood Other chromatographic methods Quality Control Reference Standards Reference Values Reproducibility of Results Spectrometric and optical methods Spectrometry, Mass, Electrospray Ionization - methods Tritium
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