Increased Positive Electrostatic Potential in p-Hydroxybenzoate Hydroxylase Accelerates Hydroxylation but Slows Turnover

Para-hydroxybenzoate hydroxylase is a flavoprotein monooxygenase that catalyzes a reaction in two parts: reduction of the enzyme cofactor, FAD, by NADPH in response to binding p-hydroxybenzoate to the enzyme, and oxidation of reduced FAD with oxygen to form a hydroperoxide, which then oxygenates p-...

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Veröffentlicht in:	Biochemistry (Easton) 2004-02, Vol.43 (6), p.1569-1579
Hauptverfasser:	Ortiz-Maldonado, Mariliz, Cole, Lindsay J, Dumas, Sara M, Entsch, Barrie, Ballou, David P
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxybenzoate-3-Monooxygenase - chemistry 4-Hydroxybenzoate-3-Monooxygenase - genetics 4-Hydroxybenzoate-3-Monooxygenase - isolation & purification Amino Acid Substitution - genetics Binding Sites - genetics Catalysis Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - isolation & purification Glutamic Acid - genetics Glutamine - genetics Hydrogen-Ion Concentration Hydroxylation Oxidation-Reduction Oxygen - chemistry Parabens - chemistry Static Electricity Substrate Specificity - genetics
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