Synthesis of DNA with Phenanthridinium as an Artificial DNA Base

A phenanthridinium-containing DNA building block was synthesized as an ethidium nucleoside analogue starting from 3,8-diamino-6-phenyl-phenanthridine. Using this building block, oligonucleotides bearing the phenanthridinium moiety as an artificial DNA base were prepared via automated solid-phase pho...

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Veröffentlicht in:	Journal of organic chemistry 2004-02, Vol.69 (3), p.744-751
Hauptverfasser:	Huber, Robert, Amann, Nicole, Wagenknecht, Hans-Achim
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Analytical, structural and metabolic biochemistry Base Sequence Biological and medical sciences Chemistry Circular Dichroism DNA - chemical synthesis DNA - chemistry Dna, deoxyribonucleoproteins Exact sciences and technology Fundamental and applied biological sciences. Psychology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Nucleic Acid Conformation Nucleic Acid Denaturation Nucleic acids Oligonucleotides - chemical synthesis Organic chemistry Phenanthridines - chemistry Preparations and properties Spectrometry, Fluorescence Spectrophotometry, Ultraviolet Temperature
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