Interaction of factor Xa with heparin does not contribute to the inhibition of factor Xa by antithrombin III-heparin

Factor Xa modified by reductive methylation (greater than 92%) loses the capacity to bind heparin as determined both by gel chromatography and by sedimentation equilibrium ultracentrifugation. The kinetic properties of methylated factor Xa differ, with respect to KM and Vmax for a synthetic tripepti...

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Veröffentlicht in:	Biochemistry (Easton) 1990-10, Vol.29 (40), p.9412-9417
Hauptverfasser:	Owen, Barbara A, Owen, Whyte G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antithrombin III - pharmacology Biological and medical sciences Blood coagulation. Blood cells Cattle Coagulation factors Factor Xa - chemistry Factor Xa - metabolism Factor Xa Inhibitors Fundamental and applied biological sciences. Psychology Heparin - metabolism Heparin - pharmacology In Vitro Techniques Kinetics Methylation Molecular and cellular biology Protein Binding
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